scholarly journals Systematic selection of competing metabolomics methods in a metabolite-sensory relationship study

Metabolomics ◽  
2021 ◽  
Vol 17 (9) ◽  
Author(s):  
Naser Davarzani ◽  
Carmen Diez-Simon ◽  
Justus L. Großmann ◽  
Doris M. Jacobs ◽  
Rudi van Doorn ◽  
...  
Keyword(s):  
Sensory Profile ◽  
Small Set ◽  
Selection For ◽  
Systematic Selection ◽  
The Relationship ◽  
Tomato Soup ◽  
Final Selection ◽  
Selection Of

Abstract Introduction The relationship between the chemical composition of food products and their sensory profile is a complex association confronting many challenges. However, new untargeted methodologies are helping correlate metabolites with sensory characteristics in a simpler manner. Nevertheless, in the pilot phase of a project, where only a small set of products are used to explore the relationships, choices have to be made about the most appropriate untargeted metabolomics methodology. Objective To provide a framework for selecting a metabolite-sensory methodology based on: the quality of measurements, the relevance of the detected metabolites in terms of distinguishing between products or in terms of whether they can be related to the sensory attributes of the products. Methods In this paper we introduce a systematic approach to explore all these different aspects driving the choice for the most appropriate metabolomics method. Results As an example we have used a tomato soup project where the choice between two sampling methods (SPME and SBSE) had to be made. The results are not always consistently pointing to the same method as being the best. SPME was able to detect metabolites with a better precision, SBSE seemed to be able to provide a better distinction between the soups. Conclusion The three levels of comparison provide information on how the methods could perform in a follow up study and will help the researcher to make a final selection for the most appropriate method based on their strengths and weaknesses.

scholarly journals HGG-47. DECREASED GROWTH VELOCITY WITH LONG TERM USE OF BRAFV600e AND MEK INHIBITION IN A PATIENT WITH ANAPLASTIC GANGLIOGLIOMA

2020 ◽  
Vol 22 (Supplement_3) ◽  
pp. iii352-iii352
Author(s):  
Hung Tran ◽  
Robert Cooper
Keyword(s):  
Growth Velocity ◽  
Direct Result ◽  
Chromosomal Microarray ◽  
Mek Inhibition ◽  
Follow Up Study ◽  
The Family ◽  
The Relationship

Abstract PURPOSE To describe decreased growth velocity with long term use of BRAFV600e and MEK inhibition in a patient with anaplastic ganglioglioma. RESULTS 4-year-old patient was found to have a 6 x 4.6 x 5 cm mass in the hypothalamus. Pathology consistent with anaplastic ganglioglioma and chromosomal microarray revealed a BRAFV600e mutation. Patient started on dabrafenib and trametinib and tumor decreased 85% after 3 months. She is stable without significant toxicities 39 months on therapy, and is now 8 years old. Patient had been growing at the 25% for weight and 12% for height but is now 65% for weight and 0.5% for height. It is difficult to tease out the relationship between the tumor, the location of the tumor, and the BRAF and MEK inhibitors and their effect on growth. Discussions with the family and endocrinology are ongoing but being <1% for height will lead to decrease in quality of life. CONCLUSIONS Further follow-up study is needed to determine if this is truly a long-term toxicity, or if this may just be a direct result of the location of the tumor. Would supplementation with growth hormone in this patient lead to losing control of a high grade tumor, or would it simply replace a hormone that is not produced?

The relationship between religiosity/spirituality and quality of life among female Eritrean refugees living in Norwegian asylum centres

2021 ◽  
pp. 002076402110102
Author(s):  
Ruth Abraham ◽  
Marja Leonhadt ◽  
Lars Lien ◽  
Ingrid Hansen ◽  
Edvard Hauff ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Mental Health Problems ◽  
World Health ◽  
Host Countries ◽  
Follow Up Study ◽  
Quality Of Life Measures ◽  
Social Quality Of Life ◽  
The Relationship

Background: Women are more vulnerable to mental health problems than men after migration, but little is known about the influence of religiosity/spirituality on their quality of life. The purpose of this study was to explore religiosity/spirituality, in relationships with various domains of quality of life, among female Eritrean refugees staying in Norwegian asylum centres. Method: A questionnaire assessing sociodemographic characteristics was used together with the World Health OrganizationQuality of Life – Spirituality, Religiosity and Personal Beliefs (WHOQOL-SRPB) questionnaire, which assesses religiosity/spirituality and domains of quality of life. A total of 63 adult female Eritrean refugees who had been granted asylum but were still living in asylum reception centres located in southern and central Norway participated. Results: Religiosity/spirituality was independently associated with psychological quality of life ( B = 0.367, p < .001), level of independence ( B = 0.184, p = .028), social quality of life ( B = 0.500, p = .003), environmental quality of life ( B = 0.323, p < .001) and overall quality of life ( B = 0.213, p < .001), but not with physical quality of life ( B = 0.056, p = .679). There were no significant differences between religious affiliations on religiosity/spirituality or quality of life measures. Conclusion: Consistent with previous research, this study highlights the correlation between religiosity/spirituality and overall quality of life. We recommend a longitudinal follow-up study of similar populations, after they are resettled and integrated into their host countries, to understand the associations between quality of life and religiosity/spirituality over time.

Upfront cytoreductive surgery versus neoadjuvant chemotherapy in advanced epithelial ovarian cancer in Indian patients

2021 ◽  
Author(s):  
Mukur Dipi Ray ◽  
Suryanarayana S.V. Deo ◽  
Lalit Kumar ◽  
Manish Kumar Gaur
Keyword(s):  
Ovarian Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Ovarian Carcinoma ◽  
Cytoreductive Surgery ◽  
Advanced Ovarian Cancer ◽  
Advanced Stages ◽  
Selection For ◽  
Selection Of Patients ◽  
Selection Of

In cases of ovarian carcinoma, primary cytoreductive surgery (CRS) is the standard treatment up to stage IIIB, but patient selection for neoadjuvant chemotherapy (NACT) in selected cases is controversial. A total of 200 patients with advanced ovarian cancer were analyzed retrospectively, according to specific selection criteria. Primary CRS was performed in 95 patients (47.5%) and interval CRS after 3–6 cycles of NACT was performed in 105 patients (52.5%). After median follow-up of 35 months, 5-year overall survival was 53.7% in the upfront CRS group and 42.2% in the NACT group. Primary CRS is the standard in advanced stages of ovarian carcinoma, but in certain subset of patients, NACT is preferred. Identifying that group is challenging but feasible. Proper selection of patients is key to successful outcomes.

Use of IoT and Different Biofeedback to Measure TTH

2021 ◽  
pp. 486-525
Author(s):  
Rohit Rastogi ◽  
Devendra Kumar Chaturvedi ◽  
Mayank Gupta
Keyword(s):  
Random Sampling ◽  
International Headache Society ◽  
Research Work ◽  
Time Duration ◽  
Visual Biofeedback ◽  
Starting Point ◽  
Sf 36 ◽  
Selection Of

This chapter applied the random sampling in selection of the subjects suffering with headache, and care was taken that they ensure to fulfill the International Headache Society criteria. Subjects under consideration were assigned the two groups of GSR-integrated audio-visual feedback, GSR (audio-visual)- and EMG (audio-visual)-integrated feedback groups. In 10 sessions, the subjects experienced the GSR and EMG BF therapy for 15 minutes. Twenty subjects were subjected to EEG therapy. The variables for stress (pain) and SF-36 (quality of life) scores were recorded at starting point, 30 days, and 90 days after the starting of GSR and EMG-BF therapy. To reduce the anxiety and depression in day-to-day routine, the present research work is shown as evidence in favor of the mindful meditation. The physical, mental, and total scores increased over the time duration of SF-36 scores after 30- and 90-days recordings (p<0.05). Intergroup analysis has demonstrated the improvement. EMG-audio visual biofeedback group also showed highest improvement in SF-36 scores at first and third month follow up. EEG measures the Alpha waves for the subjects after meditation. GSR, EMG, and EEG-integrated auditory-visual biofeedback are efficient in solution of stress due to TTH with most advantage seen.

Straightening Technology Research of Aluminum Profile for Vehicle

2010 ◽  
Vol 145 ◽  
pp. 449-452
Author(s):  
Jian Jun Hao ◽  
Qing Xue Huang ◽  
Xue Liang Zhang
Keyword(s):  
Process Parameters ◽  
Technology Research ◽  
Aluminum Profile ◽  
The Relationship ◽  
Selection Of

Based on straightening principle of profile straightening equipment, the relationship between process parameters and quality of profile straightening is studied, which can provide basis for optimization and selection of process parameters.

Prospective Clinical and Epidemiological Evaluation of rHuEPO in the Routine Care of a Network of Hematological Centers.

Blood ◽  
2004 ◽  
Vol 104 (11) ◽  
pp. 5290-5290
Author(s):  
Tiziano Barbui ◽  
Marilena Romero ◽  
Federica Delaini ◽  
Elisa Sasso ◽  
Gianni Tognoni ◽  
...  
Keyword(s):  
Hematological Malignancies ◽  
Routine Care ◽  
Routine Practice ◽  
First Line ◽  
Clinical Utilization ◽  
Epidemiological Evaluation ◽  
Epidemiological Profile ◽  
The Relationship

Abstract The expected effects of rHuEPO treatments on the quality of life of patients exposed to chemotherapeutic regimens have favored its widespread clinical utilization, even in the absence of a solid consensus on the criteria for assuring an optimal cost-effectiveness and safety profile. A prospective multicenter outcomes-oriented observational protocol adopted by a network of 29 hematological centers has explored specifically the relationship between the yield of rHuEPO, therapy and the levels of endogenous EPO in a cohort of 478 consecutively diagnosed patients (55% males), with NHL (43%), CLL (16%), MM (41%), in first (287, 60%) and successive (191, 40%) chemotherapy line. Over the 12 months follow-up, 4/252 and 32/226 patients with Hb > 11 g/dl and < 11 g/dl died; up to 20% of those with inadequate EPO levels did not receive rHuEPO, while 16/35 (46%) of those with adequate EPO levels were prescribed rHuEPO. At a multivariate analysis, only patients with baseline Hb levels between 10 and 11 g/dl and in first line chemotherapy regimen, but not those with levels < 10 g/dl or in > 1st. line therapy benefited from rHuEPO. Conclusions: While providing an informative epidemiological profile of the patients exposed to rHu EPO during chemotherapy and of the care they receive in the routine practice of specialized centers, the study documents some of the areas of uncertain practice, and confirms the need of prospective, controlled trials in the specific value of rHu EPO in well-characterized subpopulations on chemotherapy for hematological malignancies.

Special Issue on Selected Papers from ROBOMEC'06 (Part 1)

2007 ◽  
Vol 19 (2) ◽  
pp. 133-133
Author(s):  
Kiyoshi Komoriya ◽  
◽  
Shigeki Sugano ◽  
Keyword(s):  
Quality Of Life ◽  
Japan Society ◽  
Special Issue ◽  
Program Chair ◽  
Aged Society ◽  
Robot Technology ◽  
Selection For ◽  
Advanced Robotics ◽  
Final Selection

The 2006 JSME Conference on Robotics and Mechatronics (ROBOMEC'06) was held at Waseda University and Shinjuku Cosmic Center, Tokyo, Japan, on May 26-28, 2006, sponsored by the Robotics and Mechatronics Division of the Japan Society of Mechanical Engineers. Prof. Fujie of Waseda University served as general chair and Prof. Sugano of Waseda University as program chair. The conference, whose theme was ""Robot Technology Integration for Improved Quality of Life,"" was to help establish new life style in coming aged society using advanced robotics and mechatronics technologies. Organized sessions numbered 63 and papers 883, again a record for the conference. This special issue presents 13 papers from the conference culled from 90 outstanding presentations – some 14% of the total – which were further narrowed to 37 before final selection for Part 1 (Vol.19, No.2). We thank the authors for their invaluable contributions to this issue and the reviewers for their time and effort. We also thank the former Editor-in-Chief Prof. Makoto Kaneko of Osaka University for organizing this special issue.

scholarly journals Relationship between Ceftolozane-Tazobactam Exposure and Selection for Pseudomonas aeruginosa Resistance in a Hollow-Fiber Infection Model

2014 ◽  
Vol 58 (10) ◽  
pp. 6024-6031 ◽  
Author(s):  
Brian D. VanScoy ◽  
Rodrigo E. Mendes ◽  
Mariana Castanheira ◽  
Jennifer McCauley ◽  
Sujata M. Bhavnani ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Infection Model ◽  
Drug Resistant ◽  
Wild Type ◽  
Resistance Selection ◽  
Atcc Strain ◽  
Dosing Regimens ◽  
Selection For ◽  
The Relationship ◽  
Selection Of

ABSTRACTIt is important to understand the relationship between antibiotic exposure and the selection of drug resistance in the context of therapy exposure. We sought to identify the ceftolozane-tazobactam exposure necessary to prevent the amplification of drug-resistant bacterial subpopulations in a hollow-fiber infection model. TwoPseudomonas aeruginosachallenge isolates were selected for study, a wild-type ATCC strain (ceftolozane-tazobactam MIC, 0.5 mg/liter) and a clinical isolate (ceftolozane-tazobactam MIC, 4 mg/liter). The experiment duration was 10 days, and the ceftolozane-tazobactam dose ratio (2:1) and dosing interval (every 8 h) were selected to approximate those expected to be used clinically. The studied ceftolozane-tazobactam dosing regimens ranged from 62.5/31.25 to 2,000/1,000 mg per dose in step fold dilutions. Negative-control arms included no treatment and tazobactam at 500 mg every 8 h. Positive-control arms included ceftolozane at 1 g every 8 h and piperacillin-tazobactam dosed at 4.5 g every 6 h. For the wild-type ATCC strain, resistance was not selected by any ceftolozane-tazobactam regimen evaluated. For the clinical isolate, an inverted-U-shaped function best described the relationship between the amplification of a drug-resistant subpopulation and drug exposure. The least (62.5/31.25 mg) and most (2,000/1,000 mg) intensive ceftolozane-tazobactam dosing regimens did not select for drug resistance. Drug resistance selection was observed with intermediately intensive dosing regimens (125/62.5 through 1,000/500 mg). For the intermediately intensive ceftolozane-tazobactam dosing regimens, the duration until the selection for drug resistance increased with dose regimen intensity. These data support the selection of ceftolozane-tazobactam dosing regimens that minimize the potential for on-therapy drug resistance selection.

Selection practices in dairy herds. 1. First lactation performance and survival to the second lactation

1966 ◽  
Vol 8 (3) ◽  
pp. 467-480 ◽  
Author(s):  
C. J. M. Hinks
Keyword(s):  
Milk Yield ◽  
Selection Procedure ◽  
Dairy Herds ◽  
Productive Capacity ◽  
Lactation Performance ◽  
Selection For ◽  
Calving Season ◽  
Main Determinants ◽  
The Relationship ◽  
Selection Of

1. The relationship between first lactation performance and the ability of individual animals to survive to the second lactation has been examined in Friesian and Ayrshire populations in an attempt to isolate the main determinants of survival, and to rationalise an apparently complicated selection procedure.2. Low milk yield was the most important single cause of culling in the first lactation, though the two breeds differed considerably in the relative importance of milk yield in the selection programme. Natural wastage, caused by factors beyond the control of the farmer, accounted for the disposal of 5·7% of the population during the first lactation. Selection for butterfat was marginal in both populations, and could only be detected at extreme butterfat percentages, where high butterfat tended to compensate for a poor milk yield, and low butterfat to confirm a decision to cull an average yielding animal. Survival was not significantly affected either by the size of the herd or by the age at calving.3. The proportion culled, and the intensity and effectiveness of selection for milk yield, were inversely related to the level of herd performance, and were greater in summer calving animals than in winter calvers.4. The analysis indicated that selection for milk yield in different environments could be adequately described in terms of the Normal Curve. Yield-survival curves were computed and compared for groups of animals in different herd and calving season environments. When milk yield was expressed in terms of the deviation from the herd-year average, it was found that summer calvers, and animals in low yielding herds, had to demonstrate a productive capacity of far greater individual merit, if their chances of survival were to match those of their winter calving herdmates, and those of their contemporaries in higher yielding herds. When milk yield was expressed in absolute terms the survival of individual animals of similar yield was comparable in all herd and season environments. It was concluded that all the herds included in the analysis had been subject to the same absolute standards of milk yield in the selection of first calvers.

scholarly journals APPLICATION OF ORIGINAL WOVEN SURFACE DESIGNS ON THE CLOTHING

2020 ◽  
Vol 9 (72) ◽  
Keyword(s):  
Woven Fabrics ◽  
Woven Fabric ◽  
Color Selection ◽  
Clothing Design ◽  
Weave Fabric ◽  
Selection For ◽  
Fabric Design ◽  
Different Parts ◽  
Selection Of

Woven fabrics date back to the ancient ages and have been extensively used particularly in apparel, home textile, and other industries. The selection of yarn and knitting technique are among the important factors in fabrication of woven fabric surfaces with high aesthetical value. Particularly color selection for yarn used in fabrication of woven fabrics has a significant effect on the appearance of the final product. The ever-increasing quality of life brings about the need for new and different looks among individuals. In this work, the course of development and fabrication for a simple woven fabric has been studied, and the obtained products were used in apparel designs. In this context, first the theme was determined, and then pattern designs and patterns were woven in 25*25 cm size. The woven fabrics were used as detail on different parts of outfits designed under the theme “steet fashion”. Also, two of the designs were chosen and manufactured as final-products. Accordingly, different and modern designs were introduced by bringing the obtained woven surfaces together with dresses. Keywords: woven design, plain weave, fabric design, clothing design

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