P60.03 Transcriptome and Genome Profiles of Metastatic Lung Cancers Highlighted Predictive Power of Infection-Related Model in Metastasis

Aim: We report an exploratory analysis of cfRNA as a biomarker to monitor clinical responses in non-small cell lung cancer (NSCLC), breast cancer, and colorectal cancer (CRC). An analysis of cfRNA as a method for measuring PD-L1 expression with comparison to clinical responses was also performed in the NSCLC cohort. Methods: Blood samples were collected from 127 patients with metastatic disease that were undergoing therapy, 52 with NSCLC, 50 with breast cancer, and 25 with CRC. cfRNA was purified from fractionated plasma, and following reverse transcription (RT), total cfRNA and gene expression of PD-L1were analyzed by real-time polymerase chain reaction (qPCR) using beta-actin expression as a surrogate for relative amounts of cfDNA and cfRNA. For the concordance study of liquid biopsies and tissue biopsies, the isolated RNA was analyzed by RNAseq for the expressions of 13 genes. We had to close the study early due to a lack of follow-up during the Covid-19 pandemic. Results: We collected a total of 373 blood samples. Mean cfRNA PCR signals after RT were about 50-fold higher than those of cfDNA. cfRNA was detected in all patients, while cfDNA was detected in 88% of them. A high concordance was found for the expression levels of 13 genes between blood and solid tumor tissue. Changes in cfRNA levels followed over the course of treatments were associated with response to therapy, increasing in progressive disease (PD) and falling when a partial response (PR) occurred. The expression of PD-L1 over time in patients treated with immunotherapy decreased with PR but increased with PD. Pre-treatment levels of PD-L1 were predictive of response in patients treated with immunotherapy. Conclusion: Changes in cfRNA correlate with clinical response to the therapy. Total cfRNA may be useful in predicting clinical outcomes. PD-L1 gene expression may provide a biomarker to predict response to PD-L1 inhibition.

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Surgical Treatment of Local Recurrence After Stereotactic Body Radiotherapy for Primary and Metastatic Lung Cancers

Journal of Thoracic Oncology ◽

10.1097/jto.0b013e3181f8a785 ◽

2010 ◽

Vol 5 (12) ◽

pp. 2003-2007 ◽

Cited By ~ 49

Author(s):

Shinya Neri ◽

Yutaka Takahashi ◽

Takuya Terashi ◽

Hiroshi Hamakawa ◽

Keisuke Tomii ◽

...

Keyword(s):

Surgical Treatment ◽

Local Recurrence ◽

Stereotactic Body Radiotherapy ◽

Lung Cancers ◽

Metastatic Lung

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Radiofrequency Ablation of Primary and Metastatic Lung Cancers

Seminars in Ultrasound CT and MRI ◽

10.1053/j.sult.2008.12.001 ◽

2009 ◽

Vol 30 (2) ◽

pp. 113-124 ◽

Cited By ~ 13

Author(s):

Bradley B. Pua ◽

Stephen B. Solomon

Keyword(s):

Radiofrequency Ablation ◽

Lung Cancers ◽

Metastatic Lung

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Evaluation of Pentavalent Tc-99m DMSA Scintigraphy in Small Cell and Nonsmall Cell Lung Cancers

Nuklearmedizin ◽

10.1055/s-0038-1629830 ◽

1997 ◽

Vol 36 (07) ◽

pp. 223-227 ◽

Cited By ~ 3

Author(s):

C. Gündoğdu ◽

G. Vural ◽

L. Ö. Kapucu ◽

A. Karalezli ◽

M. Ünlü ◽

...

Keyword(s):

Lung Cancer ◽

Bone Metastases ◽

Lung Carcinoma ◽

Lung Abscess ◽

Small Cell ◽

Whole Body ◽

Imaging Method ◽

Whole Body Imaging ◽

Lung Cancers ◽

Metastatic Lung

Summary Aim: The purpose of this study was to evaluate the clinical usefulness of Tc-99m (V) DMSA in patients suspected of lung cancer and determine whether this agent may have value in differentiation between small cell (SCLC) and non-small cell (NSCLC) lung carcinoma. Methods: Thirty-six patients with clinical and radiological suspicion of primary lung carcinoma were injected 450-600 MBq of Tc-99m (V) DMSA intravenously. Whole body and planar anterior, posterior thorax images were obtained 4-5 h after injection of the radioactive complex. Results: Histo-pathological results confirmed 23 NSCLC, 10 SCLC and 1 metastatic lung carcinoma and 2 lung abscess. Nineteen of the 23 (82%) NSCLC and all of the 10 (100%) SCLC cases showed Tc-99m (V) DMSA uptake. Single metastatic lung cancer also accumulated radiotracer. Lung abscess did not show uptake. Lesion/Nonlesion (L/N) ratio of SCLC (1.59 ± 0.32) and NSCLC (1.43 ± 0.19) tumour types did not show statistical difference (p >0.05). Tc-99m (V) DMSA whole body imaging also showed bone metastases. Conclusion: Tc-99m (V) DMSA is a noninvasive and cheap imaging method to detect malignant lung cancers and their bone metastases but, differentiation of SCLC and NSCLC is not possible.

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Clinical Outcomes of Stereotactic Body Radiation Therapy Using Flattening Filter Free (FFF) in Early Non–Small Cell Lung Cancers and Metastatic Lung Cancers

International Journal of Radiation Oncology*Biology*Physics ◽

10.1016/j.ijrobp.2017.01.162 ◽

2017 ◽

Vol 98 (1) ◽

pp. 236

Author(s):

S. Kitpanit ◽

A. Songthong ◽

C. Chakkabat ◽

N. Amornwichet ◽

P. Alisanant ◽

...

Keyword(s):

Radiation Therapy ◽

Clinical Outcomes ◽

Stereotactic Body Radiation Therapy ◽

Small Cell ◽

Small Cell Lung ◽

Lung Cancers ◽

Stereotactic Body Radiation ◽

Flattening Filter Free ◽

Metastatic Lung ◽

Flattening Filter

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Expectations About the Effectiveness of Radiation Therapy Among Patients With Incurable Lung Cancer

Journal of Clinical Oncology ◽

10.1200/jco.2012.48.5748 ◽

2013 ◽

Vol 31 (21) ◽

pp. 2730-2735 ◽

Cited By ~ 57

Author(s):

Aileen B. Chen ◽

Angel Cronin ◽

Jane C. Weeks ◽

Elizabeth A. Chrischilles ◽

Jennifer Malin ◽

...

Keyword(s):

Lung Cancer ◽

Radiation Therapy ◽

Outcomes Research ◽

Older Patients ◽

Patient Expectations ◽

Metastatic Lung Cancer ◽

Lung Cancers ◽

Factors Associated ◽

Metastatic Lung ◽

Care Outcomes

Purpose Although radiation therapy (RT) can palliate symptoms and may prolong life, it is not curative for patients with metastatic lung cancer. We investigated patient expectations about the goals of RT for incurable lung cancers. Patients and Methods The Cancer Care Outcomes Research and Surveillance Consortium enrolled a population- and health system–based cohort of patients diagnosed with lung cancer from 2003 to 2005. We identified patients with stage wet IIIB or IV lung cancer who received RT and answered questions on their expectations about RT. We assessed patient expectations about the goals of RT and identified factors associated with inaccurate beliefs about cure. Results In all, 384 patients completed surveys on their expectations about RT. Seventy-eight percent of patients believed that RT was very or somewhat likely to help them live longer, and 67% believed that RT was very or somewhat likely to help them with problems related to their cancer. However, 64% did not understand that RT was not at all likely to cure them. Older patients and nonwhites were more likely to have inaccurate beliefs, and patients whose surveys were completed by surrogates were less likely to have inaccurate beliefs. Ninety-two percent of patients with inaccurate beliefs about cure from RT also had inaccurate beliefs about chemotherapy. Conclusion Although patients receiving RT for incurable lung cancer believe it will help them, most do not understand that it is not at all likely to cure their disease. This indicates a need to improve communication regarding the goals and limitations of palliative RT.

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Metastatic lung adenocarcinoma in appearance of diminutive colonic polyp

Gastroenterology Insights ◽

10.4081/gi.2015.6098 ◽

2015 ◽

Vol 6 (1) ◽

Author(s):

Bora Aktaş ◽

Ferdane Sapmaz ◽

Sebahat Başyiğit ◽

Metin Uzman

Keyword(s):

Lung Adenocarcinoma ◽

Distant Metastasis ◽

Clinical Case ◽

Colonic Polyp ◽

Initial Diagnosis ◽

Primary Adenocarcinoma ◽

Colonic Metastasis ◽

Lung Cancers ◽

Adenocarcinoma Of The Lung ◽

Metastatic Lung

Although about 50% of lung cancers have distant metastasis at the time of initial diagnosis, colonic metastases are extremely rare. This report presents a rare clinical case of colonic metastasis from primary adenocarcinoma of the lung.

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