Convenient, Large-Scale Synthesis of (S)-TRIP Using Suzuki Cross-Coupling Conditions

2022 ◽  
Author(s):  
Ramesh Mamidala ◽  
Chandrasekhar Kommuri ◽  
Justin Paulose ◽  
Hema Aswath ◽  
Lokesh Pawar ◽  
...  
Keyword(s):  
Large Scale ◽  
Cross Coupling ◽  
Coupling Conditions ◽  
Large Scale Synthesis

Synthesis and cross coupling of a highly substituted 2-pyridylboronate: application to the large scale synthesis of a mineralocorticoid antagonist

2011 ◽  
Vol 52 (52) ◽  
pp. 7025-7029 ◽  
Author(s):  
Charles Boos ◽  
Daniel M. Bowles ◽  
Cuiman Cai ◽  
Agustin Casimiro-Garcia ◽  
Xiangyang Chen ◽  
...  
Keyword(s):  
Large Scale ◽  
Cross Coupling ◽  
Mineralocorticoid Antagonist ◽  
Large Scale Synthesis

Large-Scale Synthesis of Alkyne-Linked Tripodal Porphyrins via Palladium-Mediated Coupling Conditions.

ChemInform ◽  
2006 ◽  
Vol 37 (31) ◽  
Author(s):  
Lok H. Tong ◽  
Sofia I. Pascu ◽  
Thibaut Jarrosson ◽  
Jeremy K. M. Sanders
Keyword(s):  
Large Scale ◽  
Coupling Conditions ◽  
Large Scale Synthesis

Large-scale synthesis of alkyne-linked tripodal porphyrins via palladium-mediated coupling conditions

2006 ◽  
pp. 1085 ◽  
Author(s):  
Lok H. Tong ◽  
Sofia I. Pascu ◽  
Thibaut Jarrosson ◽  
Jeremy K. M. Sanders
Keyword(s):  
Large Scale ◽  
Coupling Conditions ◽  
Large Scale Synthesis

Exogenous Directing Group Free, Ligand-Enabled gamma-C(sp3)–H Arylation of Free Primary Aliphatic Amines and α-Amino Esters

2019 ◽  
Author(s):  
Yongzheng Ding ◽  
Shuai Fan ◽  
Xiaoxi Chen ◽  
yuzhen gao ◽  
Gang Li
Keyword(s):  
Amino Acids ◽  
Large Scale ◽  
Free Ligand ◽  
Aliphatic Amines ◽  
Rapid Synthesis ◽  
Amino Esters ◽  
Directing Group ◽  
Large Scale Synthesis ◽  
Primary Aliphatic Amines

A Pdᴵᴵ-catalyzed, ligand-enabled gamma-C(sp3)–H arylation of free primary aliphatic amines and amino esters without using an exogenous directing group is reported. This reaction is compatible with unhindered free aliphatic amines, and it is also be applicable to the rapid synthesis of biologically and synthetically valuable unnatural α-amino acids. Large scale synthesis is also feasible using this method.<br>

A Simplified Protocol for the ortho-Deuteration of Acidic Aromatic Compounds in D2O

2019 ◽  
Author(s):  
Alyssa Garreau ◽  
Hanyang Zhou ◽  
Michael Young
Keyword(s):  
Carboxylic Acid ◽  
Aromatic Compounds ◽  
Large Scale ◽  
Simplified Approach ◽  
Directing Group ◽  
Large Scale Synthesis

<div>Methods to catalytically introduce deuterium in synthetically useful yields ortho to a carboxylic acid directing group on arenes typically requires D2 or CD3CO2D, which makes using these approaches cost prohibitive for large scale synthesis (equipment and reagent costs respectively). Herein we present a simplified approach using catalytic RhIII and D2O as deuterium source, and show its application to H/D exchange on various acidic substrates.</div>

A Simplified Protocol for the ortho-Deuteration of Acidic Aromatic Compounds in D2O

2019 ◽  
Author(s):  
Alyssa Garreau ◽  
Hanyang Zhou ◽  
Michael Young
Keyword(s):  
Carboxylic Acid ◽  
Aromatic Compounds ◽  
Large Scale ◽  
Simplified Approach ◽  
Directing Group ◽  
Large Scale Synthesis

<div>Methods to catalytically introduce deuterium in synthetically useful yields ortho to a carboxylic acid directing group on arenes typically requires D2 or CD3CO2D, which makes using these approaches cost prohibitive for large scale synthesis (equipment and reagent costs respectively). Herein we present a simplified approach using catalytic RhIII and D2O as deuterium source, and show its application to H/D exchange on various acidic substrates.</div>

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