scholarly journals Phenome-Wide Association Study of Actigraphy in the UK Biobank

2021 ◽  
Author(s):  
Thomas G. Brooks ◽  
Nicholas F. Lahens ◽  
Gregory R. Grant ◽  
Yvette I. Sheline ◽  
Garret A. FitzGerald ◽  
...  
Keyword(s):  
Physical Activity ◽  
Airway Obstruction ◽  
Large Scale ◽  
Diurnal Rhythms ◽  
Uk Biobank ◽  
Daily Lives ◽  
Individualized Approach ◽  
Using Data ◽  
The Uk ◽  
Chronic Airway

AbstractWrist-worn accelerometer actigraphy devices present the opportunity for large-scale data collection from people during their daily lives. Using data from approximately 100,000 participants in the UK Biobank, actigraphy-derived measures of physical activity, sleep, and diurnal rhythms were associated in exploration and validation cohorts with a full phenome-wide set of diagnoses, biomarkers and metadata. Rhythmicity was captured by two independent models based on accelerometer and skin temperature harnessing behavioral (diurnal) and molecular (circadian) components. We found that robust rhythms significantly with biomarkers, survival, and phenotypes including diabetes, hypertension, mood disorders, and chronic airway obstruction; these associations were comparable to those with physical activity and sleep. Surprisingly, associations were mostly consistent between the sexes, while modulation by age was significant. More importantly, rhythms were found to be powerful predictors of future diseases: a two standard deviation difference in wrist temperature rhythms corresponded to increases in rate of diagnosis of 61% in diabetes, 38% in chronic airway obstruction, 27% in anxiety disorders, and 22% in hypertension. Our PheWAS of actigraphy data in the UK Biobank establishes that rhythmicity is fundamental to modeling disease trajectories, as are physical activity and sleep. Integration of long-term remote biosensing into patient care could thus afford an individualized approach to risk management.

scholarly journals Large Scale Population Assessment of Physical Activity Using Wrist Worn Accelerometers: The UK Biobank Study

PLoS ONE ◽  
2017 ◽  
Vol 12 (2) ◽  
pp. e0169649 ◽  
Author(s):  
Aiden Doherty ◽  
Dan Jackson ◽  
Nils Hammerla ◽  
Thomas Plötz ◽  
Patrick Olivier ◽  
...  
Keyword(s):  
Physical Activity ◽  
Large Scale ◽  
Uk Biobank ◽  
Population Assessment ◽  
Scale Population ◽  
The Uk

scholarly journals Fitness, Physical Activity, and Cardiovascular Disease: Longitudinal and Genetic Analyses in the UK Biobank Study

2017 ◽  
Author(s):  
Emmi Tikkanen ◽  
Stefan Gustafsson ◽  
Erik Ingelsson
Keyword(s):  
Physical Activity ◽  
Cardiovascular Disease ◽  
Grip Strength ◽  
Cardiorespiratory Fitness ◽  
Genetic Risk ◽  
Cardiovascular Events ◽  
Large Scale ◽  
Mendelian Randomization ◽  
Uk Biobank ◽  
The Uk

AbstractBackgroundExercise is inversely related with cardiovascular disease (CVD), but large-scale studies of incident CVD events are lacking. Moreover, little is known about genetic determinants of fitness and physical activity, and modifiable effects of exercise in individuals with elevated genetic risk of CVD. Finally, causal analyses of exercise traits are limited.MethodsWe estimated associations of grip strength, physical activity, and cardiorespiratory fitness with CVD and all-cause death in up to 502,635 individuals from the UK Biobank. We also examined these associations in individuals with different genetic burden on coronary heart disease (CHD) and atrial fibrillation (AF). Finally, we performed genome-wide association study (GWAS) of grip strength and physical activity, as well as Mendelian randomization analysis to assess the causal role of grip strength in CHD.FindingsGrip strength, physical activity, and cardiorespiratory fitness showed strong inverse associations with incident cardiovascular events and all-cause death (for composite CVD; HR, 0.78, 95% CI, 0.77-0.80; HR, 0.94, 95% CI, 0.93-0.95, and HR, 0.67, 95% CI, 0.63-0.71, per SD change, respectively). We observed stronger associations of grip strength with CHD and AF for individuals in the lowest tertile of genetic risk (Pinteraction = 0.006, Pinteraction = 0.03, respectively), but the inverse associations were present in each category of genetic risk. We report 27 novel genetic loci associated with grip strength and 2 loci with physical activity, with the strongest associations in FTO (rs56094641, P=3.8×10-24) and SMIM2 (rs9316077, P=1.4×10-8), respectively. By use of Mendelian randomization, we provide evidence that grip strength is causally related to CHD.InterpretationMaintaining physical strength is likely to prevent future cardiovascular events, also in individuals with elevated genetic risk for CVD.FundingNational Institutes of Health (1 R01 HL135313-01), Knut and Alice Wallenberg Foundation (2013.0126), and the Finnish Cultural Foundation.

scholarly journals Lockdown, slow down: impact of the COVID-19 pandemic on physical activity—an observational study

Open Heart ◽  
2021 ◽  
Vol 8 (1) ◽  
pp. e001600
Author(s):  
Joanne Kathryn Taylor ◽  
Haarith Ndiaye ◽  
Matthew Daniels ◽  
Fozia Ahmed
Keyword(s):  
Physical Activity ◽  
New York ◽  
Heart Association ◽  
Evaluation Study ◽  
Activity Data ◽  
Cardiac Devices ◽  
Significant Difference ◽  
New York Heart Association ◽  
Using Data ◽  
The Uk

AimsIn response to the COVID-19 pandemic, the UK was placed under strict lockdown measures on 23 March 2020. The aim of this study was to quantify the effects on physical activity (PA) levels using data from the prospective Triage-HF Plus Evaluation study.MethodsThis study represents a cohort of adult patients with implanted cardiac devices capable of measuring activity by embedded accelerometery via a remote monitoring platform. Activity data were available for the 4 weeks pre-implementation and post implementation of ‘stay at home’ lockdown measures in the form of ‘minutes active per day’ (min/day).ResultsData were analysed for 311 patients (77.2% men, mean age 68.8, frailty 55.9%. 92.2% established heart failure (HF) diagnosis, of these 51.2% New York Heart Association II), with comorbidities representative of a real-world cohort.Post-lockdown, a significant reduction in median PA equating to 20.8 active min/day was seen. The reduction was uniform with a slightly more pronounced drop in PA for women, but no statistically significant difference with respect to age, body mass index, frailty or device type. Activity dropped in the immediate 2-week period post-lockdown, but steadily returned thereafter. Median activity week 4 weeks post-lockdown remained significantly lower than 4 weeks pre-lockdown (p≤0.001).ConclusionsIn a population of predominantly HF patients with cardiac devices, activity reduced by approximately 20 min active per day in the immediate aftermath of strict COVID-19 lockdown measures.Trial registration numberNCT04177199.

scholarly journals The Validity and Value of Self-reported Physical Activity and Accelerometry in People With Schizophrenia: A Population-Scale Study of the UK Biobank

2017 ◽  
Vol 44 (6) ◽  
pp. 1293-1300 ◽  
Author(s):  
Joseph Firth ◽  
Brendon Stubbs ◽  
Davy Vancampfort ◽  
Felipe B Schuch ◽  
Simon Rosenbaum ◽  
...  
Keyword(s):  
Physical Activity ◽  
Uk Biobank ◽  
Population Scale ◽  
The Uk

S23MACHINE LEARNING METHODS TO PREDICT UNMEASURED PHENOTYPES IN LARGE-SCALE BIOBANK STUDIES: PROOF OF PRINCIPLE USING AUDIT IN THE UK BIOBANK

2019 ◽  
Vol 29 ◽  
pp. S125-S126
Author(s):  
Amanda Gentry ◽  
Roseann Peterson ◽  
Alexis Edwards ◽  
Brien Riley ◽  
B. Todd Webb
Keyword(s):  
Large Scale ◽  
Uk Biobank ◽  
Learning Methods ◽  
The Uk ◽  
Proof Of Principle

scholarly journals A socially patterned Biological Health Score and mortality in Understanding Society and UKBiobank

2019 ◽  
Vol 29 (Supplement_4) ◽  
Author(s):  
M Chadeau-Hyam ◽  
M Karimi ◽  
R Castagné ◽  
B Bodinier ◽  
C Delpierre ◽  
...  
Keyword(s):  
Uk Biobank ◽  
Health Score ◽  
Specific Mortality ◽  
Wear And Tear ◽  
Disease Specific Mortality ◽  
Biological Health ◽  
Using Data ◽  
The Uk ◽  
Disease Specific ◽  
Physiological Systems

Abstract Background It now established that social factors impact the quality of ageing, through the lifecourse stimulation/dysregulation of key physiological systems. Composite scores such as allostatic load, focusing on the response to stress, can be used to measure individual physiological wear-and-tear. Methods Using data from the Understanding Society study, a cross-sectional panel study including 9,088 participants representative of the UK population, we defined a synthetic biological health score (BHS) capturing the wear-and-tear of four physiological systems (endocrine, inflammatory, cardiovascular, and metabolic systems), and of two key organs (liver and kidney). We used 16 established blood-derived biomarkers of these systems to calculate the BHS and explored the relative contribution of socio-economic position to the BHS and its main components across age groups. Using data from UK biobank, including over 400,000 UK participants in whom similar biomarkers have been assayed in blood, we sought validation of our results and investigated the role of the BHS on all-cause and disease specific mortality, and disease incidence. Results We identified a systematic decreasing education-related gradient of the BHS (p < 0·001) leading to lower biological risk in participants with higher educational attainment. Education-related differences in the BHS were detected early in life, and were not attributable to lifestyle and behavioural factors. Analyses of the UK biobank data validated these findings and also showed that the BHS contributed in turn, irrespective of established health risk factors, to all-cause and disease specific mortality. Interpretation Our findings highlight the social-to-biological processes ultimately leading to health inequalities, and suggest that such disparities can already be detected in the 20-40 year age group.

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