scholarly journals Potential Association Between Changes in Microbiota Level and Lung Diseases: A Meta-Analysis

2022 ◽  
Vol 8 ◽  
Author(s):  
Lan Chai ◽  
Qi Wang ◽  
Caijuan Si ◽  
Wenyan Gao ◽  
Lun Zhang
Keyword(s):  
Subgroup Analysis ◽  
Lung Diseases ◽  
Hypersensitivity Pneumonitis ◽  
Meta Analysis ◽  
Mean Deviation ◽  
Chronic Obstructive ◽  
Healthy Individuals ◽  
Obstructive Pulmonary Disease ◽  
Potential Association ◽  
The Relationship

Objective:Lung microbiota is increasingly implicated in multiple types of respiratory diseases. However, no study has drawn a consistent conclusion regarding the relationship between changes in the microbial community and lung diseases. This study verifies the association between microbiota level and lung diseases by performing a meta-analysis.Methods:Literature databases, including PubMed, ISI Web of Science, Embase, Google Scholar, PMC, and CNKI, were used to collect related articles published before March 20, 2021. The standard mean deviation (SMD) and related 95% confidence intervals (CIs) were calculated using a random-effects model. Subgroup, sensitivity, and publication bias analyses were also conducted.Results:Six studies, comprising 695 patients with lung diseases and 176 healthy individuals, were included in this meta-analysis. The results indicated that the microbiota level was higher in patients with lung diseases than in healthy individuals (SMD = 0.39, 95% CI = 0.22–0.55, I2 = 91.5%, P < 0.01). Subgroup analysis based on country demonstrated that the microbiota level was significantly higher in Chinese (SMD = 1.90, 95% CI = 0.87–2.93, I2 = 62.3%, P < 0.01) and Korean (SMD = 0.24, 95% CI = 0.13–0.35, I2 = 78.7%, P < 0.01) patients with lung diseases. The microbiota level of patients with idiopathic pulmonary fibrosis (IPF) (SMD = 1.40, 95% CI = 0.42–2.38, I2 = 97.3%, P = 0.005), chronic obstructive pulmonary disease (COPD) (SMD = 0.30, 95% CI = 0.09–0.50, I2 = 83.9%, P = 0.004), and asthma (SMD = 0.19, 95% CI = 0.06–0.32, I2 = 69.4%, P = 0.004) were significantly higher than those of the healthy group, whereas a lower microbiota level was found in patients with chronic hypersensitivity pneumonitis (CHP). The microbiota level significantly increased when the disease sample size was >50. Subgroup analysis based on different microbiota genera, indicated that Acinetobacter baumannii and Pseudomonas aeruginosa were significantly increased in COPD and asthma diseases.Conclusion:We observed that patients with IPF, COPD, and asthma had a higher microbiota level, whereas patients with CHP had a lower microbiota level compared to the healthy individuals. The level of A. baumannii and P. aeruginosa were significantly higher in patients with COPD and asthma, and thus represented as potential microbiota markers in the diagnosis and treatment of lung diseases.

scholarly journals Correlation between bronchopulmonary diseases and vitamin D level

2020 ◽  
Vol 98 (11) ◽  
pp. 57-64
Author(s):  
O. V. Velikaya ◽  
L. V. Vasilieva ◽  
S. А. Nedomolkina ◽  
S. V. Nedomolkin
Keyword(s):  
Vitamin D ◽  
Lung Diseases ◽  
Serum Vitamin ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Impaired Lung Function ◽  
Bronchopulmonary Diseases ◽  
The Relationship

The review presents data from 56 publications about functions of vitamin D in the human body, the mechanisms of its action and the relationship between lung diseases and the level of vitamin D in the blood. Low serum vitamin D levels are associated with impaired lung function and an increase in inflammatory, infectious, or neoplastic diseases. The results of numerous studies allow considering vitamin D not only a marker of different courses of bronchopulmonary diseases but also as a therapeutic target in the treatment of patients with chronic obstructive pulmonary disease while maintaining the immune system and anti-infectious protection.

scholarly journals The Serpin Superfamily and Their Role in the Regulation and Dysfunction of Serine Protease Activity in COPD and Other Chronic Lung Diseases

2021 ◽  
Vol 22 (12) ◽  
pp. 6351
Author(s):  
Gillian A. Kelly-Robinson ◽  
James A. Reihill ◽  
Fionnuala T. Lundy ◽  
Lorcan P. McGarvey ◽  
John C. Lockhart ◽  
...  
Keyword(s):  
Serine Protease ◽  
Lung Diseases ◽  
Chronic Obstructive ◽  
Stable Form ◽  
Obstructive Pulmonary Disease ◽  
Chronic Lung Diseases ◽  
Mechanism Of Inhibition ◽  
Serine Protease Activity ◽  
Alpha 1 Antitrypsin ◽  
The Relationship

Chronic obstructive pulmonary disease (COPD) is a debilitating heterogeneous disease characterised by unregulated proteolytic destruction of lung tissue mediated via a protease-antiprotease imbalance. In COPD, the relationship between the neutrophil serine protease, neutrophil elastase, and its endogenous inhibitor, alpha-1-antitrypsin (AAT) is the best characterised. AAT belongs to a superfamily of serine protease inhibitors known as serpins. Advances in screening technologies have, however, resulted in many members of the serpin superfamily being identified as having differential expression across a multitude of chronic lung diseases compared to healthy individuals. Serpins exhibit a unique suicide-substrate mechanism of inhibition during which they undergo a dramatic conformational change to a more stable form. A limitation is that this also renders them susceptible to disease-causing mutations. Identification of the extent of their physiological/pathological role in the airways would allow further expansion of knowledge regarding the complexity of protease regulation in the lung and may provide wider opportunity for their use as therapeutics to aid the management of COPD and other chronic airways diseases.

scholarly journals Venous Thromboembolic Disease in Chronic Inflammatory Lung Diseases: Knowns and Unknowns

2021 ◽  
Vol 10 (10) ◽  
pp. 2061
Author(s):  
George Keramidas ◽  
Konstantinos I. Gourgoulianis ◽  
Ourania S. Kotsiou
Keyword(s):  
Lung Diseases ◽  
Thrombotic Event ◽  
Interstitial Lung Diseases ◽  
Chronic Obstructive ◽  
Predisposing Factor ◽  
Obstructive Pulmonary Disease ◽  
Chronic Lung Diseases ◽  
Increased Risk ◽  
Chronic Pulmonary Diseases ◽  
The Relationship

Persistent inflammation within the respiratory tract underlies the pathogenesis of numerous chronic pulmonary diseases. There is evidence supporting that chronic lung diseases are associated with a higher risk of venous thromboembolism (VTE). However, the relationship between lung diseases and/or lung function with VTE is unclear. Understanding the role of chronic lung inflammation as a predisposing factor for VTE may help determine the optimal management and aid in the development of future preventative strategies. We aimed to provide an overview of the relationship between the most common chronic inflammatory lung diseases and VTE. Asthma, chronic obstructive pulmonary disease, interstitial lung diseases, or tuberculosis increase the VTE risk, especially pulmonary embolism (PE), compared to the general population. However, high suspicion is needed to diagnose a thrombotic event early as the clinical presentation inevitably overlaps with respiratory disorders. PE risk increases with disease severity and exacerbations. Hence, hospitalized patients should be considered for thromboprophylaxis administration. Conversely, all VTE patients should be asked for lung comorbidities before determining anticoagulant therapy duration, as those patients are at increased risk of recurrent PE episodes rather than DVT. Further research is needed to understand the underlying pathophysiology of in-situ thrombosis in those patients.

scholarly journals Nutrition and lung health

1999 ◽  
Vol 58 (2) ◽  
pp. 303-308 ◽  
Author(s):  
Mangalam K. Sridhar
Keyword(s):  
Lung Diseases ◽  
Dietary Habits ◽  
Nutritional Therapy ◽  
Epidemiological Studies ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Salutary Effect ◽  
End Stage ◽  
Lung Health ◽  
The Relationship

There is an increasing interest in the relationship between nutrition and lung health. Epidemiological studies suggest that dietary habits may have an influence on lung function and the tendency to common lung diseases such as asthma, chronic obstructive pulmonary disease (COPD) and lung cancer. In particular, a diet rich in fresh fruit and fish has been associated with a salutary effect on lung health. End-stage COPD is associated with a state of nutritional depletion which is refractory to conventional nutritional supplementation. In contrast, malnutrition associated with cystic fibrosis is amenable to nutritional therapy, which has been shown to improve prognosis in this disease.

scholarly journals Association of the MMP-3, MMP-9 and MMP-12 gene polymorphisms with COPD risk: a meta-analysis

2021 ◽  
Author(s):  
Hua Zhao ◽  
Xiao-Hong Jiang ◽  
Qiu-Pin Huang ◽  
Min-Li Chen ◽  
Zheng-Fu Xie
Keyword(s):  
Meta Analysis ◽  
Random Effect ◽  
Group Analysis ◽  
Case Control ◽  
Chronic Obstructive ◽  
Case Control Studies ◽  
Obstructive Pulmonary Disease ◽  
Published Evidence ◽  
The Matrix ◽  
The Relationship

IntroductionGiven evidence that the matrix metalloproteinases (MMPs) play an important role in the pathogenesis of chronic obstructive pulmonary disease (COPD), a number of case-control studies have attempted to assess the relationship between genetic polymorphisms in MMP genes and COPD risk. However, reliable measures of these results are lacking.Material and methodsWe assessed the published evidence for association of the MMP-3, MMP-9 and MMP-12 polymorphisms with COPD risk using meta-analytic techniques. Odds ratio (OR) and 95% confidence intervals (CI) were calculated for each study using fixed or random effect models.ResultsA total of 23 case-control studies were included in the meta-analysis. No significant association was observed between the MMP-9 rs3918242 polymorphism and COPD risk in the overall populations under the dominant (T/T + C/T vs C/C: OR=1.30, 95% CI: 1.00-1.69, P=0.054) and allele contrast (T allele vs C allele: OR=1.22, 95% CI: 0.97-1.53, P=0.088) models. However in sub-group analysis the polymorphism rs3918242 was significant in Asians under the dominant model (T/T + C/T vs C/C: OR=1.66, 95% CI: 1.02-2.72, P=0.043). The results for MMP-12 rs2276109 showed an association with COPD only in mixed populations (G/G + A/G vs A/A: OR=1.57, 95% CI: 1.10-2.24, P=0.013; G allele vs A allele: OR=1.52, 95% CI: 1.09-2.14, P=0.015). We did not find any significant association of the MMP-12 rs652438 and MMP-3 rs35068180 polymorphisms with COPD.ConclusionsThe findings in this meta-analysis suggest that the risk of COPD is associated with the MMP-9 rs3918242 and MMP-12 rs2276109 polymorphisms in certain ethnic groups.

scholarly journals Genetic Polymorphism of Angiotensin-Converting Enzyme and Chronic Obstructive Pulmonary Disease Risk: An Updated Meta-Analysis

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Sang Wook Kang ◽  
Su Kang Kim ◽  
Joo-Ho Chung ◽  
Hee-Jae Jung ◽  
Kwan-Il Kim ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Meta Analysis ◽  
Asian Population ◽  
Caucasian Population ◽  
Chronic Obstructive ◽  
Converting Enzyme ◽  
Deletion Polymorphism ◽  
Obstructive Pulmonary Disease ◽  
The Relationship

The relationship between polymorphism of the angiotensin I converting enzyme (ACE) gene and chronic obstructive pulmonary disease (COPD) has been examined in many previous studies. However, their results were controversial. Therefore, we performed a meta-analysis to evaluate the relationship between theACEgene and the risk of COPD. Fourteen case-control studies were included in this meta-analysis. The pooledpvalue, odds ratio (OR), and 95% confidence interval (95% CI) were used to investigate the strength of the association. The meta-analysis was performed using comprehensive meta-analysis software. Our meta-analysis results revealed that ACE polymorphisms were not related to the risk of COPD (p>0.05in each model). In further analyses based on ethnicity, we observed an association between insertion/deletion polymorphism of theACEgene and risk of COPD in the Asian population (codominant 2, OR = 3.126, 95% CI = 1.919–5.093,p<0.001; recessive, OR = 3.326, 95% CI = 2.190–5.050,p<0.001) but not in the Caucasian population (p>0.05in each model). In conclusion, the present meta-analysis indicated that the insertion/deletion polymorphism of theACEgene may be associated with susceptibility to COPD in the Asian population but not in the Caucasian population. However, the results of the present meta-analysis need to be confirmed in a larger sample.

scholarly journals Work Lung Disease Due to Rice Dust

2020 ◽  
Vol 6 (3) ◽  
pp. 79
Author(s):  
Ariani Permatasari ◽  
Reagen Irwan Kolibu
Keyword(s):  
Lung Diseases ◽  
Hypersensitivity Pneumonitis ◽  
Airflow Obstruction ◽  
Lung Damage ◽  
Dust Exposure ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Respiratory Problems ◽  
Occupational Lung Diseases ◽  
Reversible Airflow Obstruction

Indonesia is one of the third largest rice producers globally; therefore, rice dust-related lung diseases will be more significant. Rice dust is easily exposed to humans, triggers lung damage, and decline the lung function. Rice dust exposure is associated with occupational lung diseases, for instance, acute reversible airflow obstruction, chronic obstructive pulmonary disease, grain fever, organic dust syndrome, and hypersensitivity pneumonitis. Smoking and the environment might aggravate rice dust-related respiratory problems. The average tolerated dose of rice dust is about less than 3 mg/m3. Avoiding exposure to rice dust is primer prevention.

Systematic review and meta-analysis of Altruistic and Game-playing Love

2020 ◽  
Author(s):  
Hossein Dabiriyan Tehrani ◽  
Sara Yamini
Keyword(s):  
Systematic Review ◽  
Subgroup Analysis ◽  
Meta Analysis ◽  
Game Playing ◽  
Love Styles ◽  
Collectivistic Culture ◽  
Meta Regression ◽  
Collectivistic Cultures ◽  
The Relationship

This systematic review aimed to find attitudes toward Altruistic and Game-playing love styles across individualistic and collectivistic cultures. Addressing major moderators concerning Altruistic and Game-playing love styles are the secondary objectives of this review. This review included 102 articles comprising samples from 37 countries (N = 41997). The findings of this meta-analysis show that there is a collectivistic and individualistic difference in Game-playing but not in the Altruistic love style. Collectivistic and individualistic cultures, on average, demonstrate the same perception concerning the Altruistic love style, whereas collectivistic culture shows the Game-playing love style more strongly. To explain the role of moderators in key measures, the subgroup analysis and meta-regression show that both Game-playing and Altruistic love styles decline by increasing the length of the relationship. Likewise, having children affects these love styles such that the Altruistic love style is improved, and the Game-playing love style is reduced by the presence of children in families.

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