Distortion Product Otoacoustic Emissions and Their Suppression as Predictors of Peripheral Auditory Damage in Migraine: A Case-Control Study

Although several cochleo-vestibular symptoms are commonly associated with migraine, only a limited number of studies have been done in this regard. Some reported abnormalities in audiometry, auditory brainstem response and vestibular tests, considering these manifestations mainly related to central etiology. However, increasing evidence also suggests a peripheral involvement of the inner ear in migraine. The aim of this study was to investigate the peripheral auditory pathway in migraineurs using otoacoustic emissions (OAEs), to detect alteration of cochlear functioning and possible relationship with disease severity. Sixty-two migraineurs and sixty matched controls were enrolled in the study and underwent a routine neuro-otolaryngology examination; self-administered questionnaires were used to evaluate subjective perception of hearing disability. DPOAE and their suppression were lower in migraineurs compared to controls and significantly related to the disease duration. Altered DPOAE exposed migraineurs to the risk of affecting by migraine without aura, of presenting with ocular and/or auditory symptoms during attack and of using more painkillers. Concomitant dopaminergic symptoms and/or allodynia such as the acute non-consumption of triptans were significant determinants of decreased contralateral suppression of DPOAE among migraineurs. This potential subclinical cochlear impairment in migraine detected by OAEs may represent the earliest sign of sensorineural damage in these patients, providing a promising tool for the initial diagnosis and an opportunity to monitor disease course and treatment response over time.

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Clinical Application of Otoacoustic Emissions: What do we Know about Factors Influencing Measurement and Analysis?

Otolaryngology ◽

10.1177/019459989411000103 ◽

1994 ◽

Vol 110 (1) ◽

pp. 22-38 ◽

Cited By ~ 15

Author(s):

James W. Hall ◽

Jane E. Baer ◽

Patricia A. Chase ◽

Mitchell K. Schwaber

Keyword(s):

Otoacoustic Emissions ◽

Large Scale ◽

Auditory Brainstem ◽

Distortion Product ◽

Clinical Investigations ◽

Gender And Age ◽

Measurement And Analysis ◽

The Everyday ◽

Brainstem Response ◽

Clinical Environments

Three electrophysiologic audiologic procedures-aural immittance measurement, auditory brainstem response (ABR), and otoacoustic emissions (OAE) — were first described in the 1970's. Immittance measurement and ABR have contributed importantly for years to the assessment of auditory function in children and adults, whereas OAEs have not yet been incorporated into the everyday audiology test battery. In this article, we argue that the transition from OAE measurement by hearing scientists in laboratory settings to routine application by audiologists in the clinic will be greatly facilitated by (1) comprehensive, large-scale studies of the effects of subject characteristics, such as gender and age (from infancy to advancing adulthood), on both transient evoked (TEOAE) and distortion product (DPOAE) otoacoustic emissions; (2) clinical investigations of TEOAE and DPOAE in sizeable patient populations with specific neurotologic diagnoses; (3) guidelines for OAE test protocols in clinical environments; and (4) clear criteria for OAE analysis in clinical populations.

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Auditory pathway maturational study in small for gestational age preterm infants

CoDAS ◽

10.1590/2317-1782/201420130078 ◽

2014 ◽

Vol 26 (4) ◽

pp. 286-293 ◽

Cited By ~ 6

Author(s):

Rosanna Giaffredo Angrisani ◽

Edna Maria Albuquerque Diniz ◽

Ruth Guinsburg ◽

Alexandre Archanjo Ferraro ◽

Marisa Frasson de Azevedo ◽

...

Keyword(s):

Preterm Infants ◽

Gestational Age ◽

Small For Gestational Age ◽

Otoacoustic Emissions ◽

Newborn Infants ◽

Tone Burst ◽

Auditory Pathway ◽

Auditory Brainstem ◽

Cross Sectional ◽

Brainstem Response

PURPOSE: To follow up the maturation of the auditory pathway in preterm infants small for gestational age (SGA), through the study of absolute and interpeak latencies of auditory brainstem response (ABR) in the first six months of age.METHODS: This multicentric prospective cross-sectional and longitudinal study assessed 76 newborn infants, 35 SGA and 41 appropriate for gestational age (AGA), born between 33 and 36 weeks in the first evaluation. The ABR was carried out in three moments (neonatal period, three months and six months). Twenty-nine SGA and 33 AGA (62 infants), between 51 and 54 weeks (corrected age), returned for the second evaluation. In the third evaluation, 49 infants (23 SGA and 26 AGA), with age range from 63 to 65 weeks (corrected age), were assessed. The bilateral presence of Transient Evoked Otoacoustic Emissions and normal tympanogram were inclusion criteria.RESULTS: It was found interaural symmetry in both groups. The comparison between the two groups throughout the three periods studied showed no significant differences in the ABR parameters, except for the latencies of wave III in the period between three and six months. As for the maturation with tone burst 0.5 and 1 kHz, it was found that the groups did not differ.CONCLUSION: The findings suggest that, in the premature infants, the maturational process of the auditory pathway occurs in a similar rate for SGA and AGA. These results also suggest that prematurity is a more relevant factor for the maturation of the auditory pathway than birth weight.

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Protective effect of ethosuximide on hearing in NOD/LtJ mice via blockage of endogenous apoptosis

Tropical Journal of Pharmaceutical Research ◽

10.4314/tjpr.v19i2.12 ◽

2020 ◽

Vol 19 (2) ◽

pp. 299-304

Author(s):

Dejun Zhang ◽

Guofang Guan ◽

Yingyuan Guo ◽

Yanru Hao ◽

Fang Guo ◽

...

Keyword(s):

Treatment Group ◽

Protective Effect ◽

Otoacoustic Emissions ◽

Caspase 3 ◽

Auditory Brainstem ◽

New Drugs ◽

Signal Frequency ◽

Control Group ◽

Distortion Product ◽

Brainstem Response

Purpose: To determine the protective effect of ethosuximide on the hearing of NOD/LtJ mice, and the underlying mechanism of action. Methods: The mice were randomly assigned to control and treatment groups (20 mice per group). Mice in the treatment group were administered ethosuximide intraperitoneally at a dose of 200mg/kg body weight (bwt), while those in the control group received an equivalent dose of saline via the same route. Both groups were subjected to auditory brainstem response (ABR) and distortion product otoacoustic emissions (DPOAE) tests, as well as determination of mRNA expressions of α1G, α1H, α1I, m-calpain, μ-calpain, and caspase-3. Results: At ages of 6 and 9 weeks, ABR values were significantly lower in the treatment group than those in the control group (p < 0.05). At age 3, 6 and 9 weeks, control group DPOAE values were much lower than those in the treatment group. However, at signal frequency of 35344 Hz, DPOAE value was significantly reduced in the treatment group (p < 0.05). There was significant down-regulation in mRNA expressions of α1G, α1H, α1I, m-calpain, μ-calpain and caspase-3, in the treatment group, when compared with the control group (p < 0.05). Conclusion: Ethosuximide delays mice hearing loss and protects their hearing via a mechanism involving blockage of endogenous apoptotic pathways. This mechanism may provide guidance in the search for suitable new drugs. Keywords: Ethosuximide, Endogenous apoptosis, Hearing, Protection

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Auditory brainstem response demonstrates that reduced peripheral auditory input is associated with self-report of tinnitus

10.31219/osf.io/cm2ve ◽

2019 ◽

Author(s):

Naomi Bramhall ◽

Garnett McMillan ◽

Frederick Gallun ◽

Dawn Konrad-Martin

Keyword(s):

Animal Models ◽

Auditory Brainstem Response ◽

Otoacoustic Emissions ◽

Auditory Brainstem ◽

Self Report ◽

Auditory Input ◽

Distortion Product ◽

Brainstem Response ◽

Temporal Bones ◽

The Relationship

Tinnitus is one of the predicted perceptual consequences of cochlear synaptopathy, a type of age-, noise-, or drug-induced auditory damage that has been demonstrated in animal models to cause homeostatic changes in central auditory gain. Although synaptopathy has been observed in human temporal bones, assessment of this condition in living humans is limited to indirect non-invasive measures such as the auditory brainstem response (ABR). In animal models, synaptopathy is associated with a reduction in ABR wave I amplitude at suprathreshold stimulus levels. Several human studies have explored the relationship between wave I amplitude and tinnitus, with conflicting results. This study investigates the hypothesis that reduced peripheral auditory input due to synaptic/neuronal loss is associated with tinnitus. ABR wave I amplitude data from 193 individuals (43 with tinnitus (22%), 150 without tinnitus (78%)), who participated in up to three out of four different studies, were included in a logistic regression analysis to estimate the relationship between wave I amplitude and tinnitus at a variety of stimulus levels and frequencies. Statistical adjustment for sex and distortion product otoacoustic emissions was included in the analysis. The results suggest that smaller ABR wave I amplitudes are associated with an increased probability of reporting tinnitus.

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The effect of coronavirus disease 2019 on the hearing system

The Journal of Laryngology & Otology ◽

10.1017/s0022215121001961 ◽

2021 ◽

pp. 1-5

Author(s):

Ö Gedik ◽

H Hüsam ◽

M Başöz ◽

N Tas ◽

F Aksoy

Keyword(s):

Auditory Brainstem Response ◽

High Frequency ◽

Otoacoustic Emissions ◽

Pure Tone ◽

Pure Tone Audiometry ◽

Auditory Brainstem ◽

Distortion Product ◽

High Frequency Audiometry ◽

Brainstem Response ◽

Hearing System

Abstract Objective This study aimed to evaluate different auditory regions with audiological tests, based on the presumption that there may be damage to the structures in the hearing system after coronavirus disease 2019. Methods Twenty individuals with no history of coronavirus disease 2019 and 27 individuals diagnosed with coronavirus disease 2019 were compared. Pure tone, speech and extended high-frequency audiometry, acoustic immitansmetry, transient evoked and distortion product otoacoustic emissions testing, and auditory brainstem response testing were conducted. Results The pure tone audiometry and extended high-frequency mean threshold values were higher in the coronavirus disease 2019 group. The transient evoked otoacoustic emissions signal-to-noise ratios were bilaterally lower at 4 kHz in individuals with a coronavirus disease 2019 history. In the auditory brainstem response test, only the interpeak latencies of waves III–V were significantly different between groups. Conclusion Coronavirus disease 2019 may cause damage to the hearing system. Patients should be followed up in the long term with advanced audiological evaluation methods in order to determine the extent and level of damage.

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Reliability of Contralateral Suppression in Evoked Distortion Product Otoacoustic Emissions

International Archives of Otorhinolaryngology ◽

10.1055/s-0041-1733928 ◽

2021 ◽

Author(s):

Ana Carolina dos Santos ◽

Ludimila Labanca ◽

Larissa Resende Assumpção ◽

Patricia Cotta Mancini ◽

Sirley Alves da Silva Carvalho ◽

...

Keyword(s):

Otoacoustic Emissions ◽

Auditory Pathway ◽

Inhibitory Effect ◽

Wilcoxon Test ◽

Distortion Product Otoacoustic Emissions ◽

Cochlear Function ◽

Cross Sectional ◽

Distortion Product ◽

Clinical Applicability ◽

Contralateral Suppression

Abstract Introduction Distortion product otoacoustic emissions (DPOAE) and their suppression may be considered useful in monitoring cochlear function and the efferent auditory pathway inhibitory effect. Nonetheless, the establishment of reliable parameters of response variations is of great importance. Objectives To verify the replicability of test and retest in the research of the inhibitory effect of the efferent pathway using contralateral suppressing stimulus during DPOAE recording for clinical applicability. Methods Cross-sectional study with 48 volunteers, aged 18 to 30 years, with normal audiometric thresholds. The procedures included were audiometric and immittance measures to overrule any conductive or sensorineural conditions and DPOAE recordings without and with contralateral suppression with a 60 dBHL white noise. Distortion product otoacoustic emissions amplitudes were analyzed and compared in both conditions with Wilcoxon test, and the Spearman correlation test was used to assess test-retest reliability. Results The comparative analysis showed differences between amplitudes in test and retest conditions only in 1,500 Hz for DPOAE measures with all other tested frequencies showing no differences, and no difference was observed in all recorded frequencies in the test and retest comparison for DPOAE suppression. The degree of correlation between test and retest of DPOAE amplitude was good at 6,000 Hz and strong (r > 0.880) at the other frequencies. For DPOAE with suppression, all frequencies presented strong correlation between test and retest: 1,500 Hz (r = 0.880), 2,000 Hz (r = 0.882), 3,000 Hz (r = 0.940), and 6,000 Hz (r = 0.957). Conclusions The study found good replicability in contralateral suppression of DPOAE with potential clinical applicability, and we recommend conducting the test from 2000Hz to higher frequencies for more reliable results.

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Contralateral Suppression of DPOAEs in Mice after Ouabain Treatment

Neural Plasticity ◽

10.1155/2018/6890613 ◽

2018 ◽

Vol 2018 ◽

pp. 1-8 ◽

Cited By ~ 3

Author(s):

Jieying Li ◽

Yan Chen ◽

Shan Zeng ◽

Chuijin Lai ◽

Yanping Zhang ◽

...

Keyword(s):

Otoacoustic Emissions ◽

Round Window ◽

Spiral Ganglion ◽

Auditory Brainstem ◽

Spiral Ganglion Neurons ◽

Type I ◽

Type Ii ◽

Contralateral Suppression ◽

Brainstem Response ◽

Ganglion Neurons

Medial olivocochlear (MOC) efferent feedback is suggested to protect the ear from acoustic injury and to increase its ability to discriminate sounds against a noisy background. We investigated whether type II spiral ganglion neurons participate in the contralateral suppression of the MOC reflex. The application of ouabain to the round window of the mouse cochlea selectively induced the apoptosis of the type I spiral ganglion neurons, left the peripherin-immunopositive type II spiral ganglion neurons intact, and did not affect outer hairs, as evidenced by the maintenance of the distorted product otoacoustic emissions (DPOAEs). With the ouabain treatment, the threshold of the auditory brainstem response increased significantly and the amplitude of wave I decreased significantly in the ouabain-treated ears, consistent with the loss of type I neurons. Contralateral suppression was measured as reduction in the amplitude of the 2f1−f2 DPOAEs when noise was presented to the opposite ear. Despite the loss of all the type I spiral ganglion neurons, virtually, the amplitude of the contralateral suppression was not significantly different from the control when the suppressor noise was delivered to the treated cochlea. These results are consistent with the type II spiral ganglion neurons providing the sensory input driving contralateral suppression of the MOC reflex.

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