Malignant melanoma of unknown origin presenting as a systemic vasculitis

1993 ◽  
Vol 129 (9) ◽  
pp. 1205b-1207 ◽  
Author(s):  
E. J. Primka
Keyword(s):  
Malignant Melanoma ◽  
Systemic Vasculitis ◽  
Unknown Origin

scholarly journals Old and New Challenges in Uveitis Associated with Behçet’s Disease

2021 ◽  
Vol 10 (11) ◽  
pp. 2318
Author(s):  
Julie Gueudry ◽  
Mathilde Leclercq ◽  
David Saadoun ◽  
Bahram Bodaghi
Keyword(s):  
Behçet’S Disease ◽  
Structural Damage ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Systemic Vasculitis ◽  
Retinal Vasculitis ◽  
Unknown Origin ◽  
Current Data ◽  
Ocular Involvement ◽  
Behcet's Disease

Behçet’s disease (BD) is a systemic vasculitis disease of unknown origin occurring in young people, which can be venous, arterial or both, classically occlusive. Ocular involvement is particularly frequent and severe; vascular occlusion secondary to retinal vasculitis may lead to rapid and severe loss of vision. Biologics have transformed the management of intraocular inflammation. However, the diagnosis of BD is still a major challenge. In the absence of a reliable biological marker, diagnosis is based on clinical diagnostic criteria and may be delayed after the appearance of the onset sign. However, therapeutic management of BD needs to be introduced early in order to control inflammation, to preserve visual function and to limit irreversible structural damage. The aim of this review is to provide current data on how innovations in clinical evaluation, investigations and treatments were able to improve the prognosis of uveitis associated with BD.

scholarly journals A young lady with inflammation of unknown origin

2018 ◽  
Vol 18 (2) ◽  
pp. 67-71
Author(s):  
Chiu Sum Chu ◽  
Chi Hung To ◽  
Chi Chiu Mok
Keyword(s):  
Young Women ◽  
Systemic Vasculitis ◽  
Unknown Origin ◽  
Young Lady ◽  
Imaging Studies ◽  
Biochemical Tests ◽  
Vascular Stenosis ◽  
High Index Of Suspicion ◽  
Anemia Of Chronic Inflammation ◽  
Delay In Treatment

Abstract Takayasu’s arteritis (TAK) is a systemic vasculitis mainly affecting the aorta and its first branches. The initial presentation can be very non-specific while its sequelae can be debilitating and fatal. Apart from clinical and biochemical tests, imaging studies remain pivotal for the diagnosis of this rare disease. Delay in treatment may result in vascular stenosis, leading to morbidity and mortality. We report a case of a young woman who presented with anemia with no obvious causes. Subsequently she developed ischemic symptoms and the diagnosis of TAK was established with magnetic resonance angiography (MRA). Our case illustrates the importance of recognition of the possibility of TAK in young women who presented with non-specific systemic upset and anemia of chronic inflammation. A high index of suspicion is needed and imaging studies should be considered early. The treatment of TAK will also be briefly reviewed.

scholarly journals Acute Posterior Multifocal Placoid Pigment Epitheliopathy Associated with Gastrointestinal Stromal Tumor and Hurthle Cell Tumor

2018 ◽  
Vol 2018 ◽  
pp. 1-4
Author(s):  
Daniel D. Kim ◽  
Ghassan Ghorayeb
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Vision Loss ◽  
Systemic Vasculitis ◽  
Unknown Origin ◽  
Simultaneous Presentation ◽  
Cell Tumor ◽  
Stromal Tumor ◽  
Hürthle Cell ◽  
Cell Renal Carcinoma ◽  
Viral Illness

Acute posterior multifocal placoid pigment epitheliopathy (APMPEE) is a chorioretinal inflammatory disease of unknown origin. Patients usually present with a rapid loss of central/paracentral vision over the course of a week in both eyes. The fundus exhibits rapid appearance of multiple deep subretinal yellow-white, flat lesions at the RPE/choriocapillaris level. This in turn causes changes of both the ellipsoid zone and RPE which can result in permanent central vision loss. The pathogenesis is controversial but is associated with a recent viral illness and can involve the central nervous system with concern for cerebral vasculitis. Rare reports of APMPEE associated with systemic vasculitis such as Wegener’s granulomatosis and malignancy such as clear cell renal carcinoma have been reported. We report a case of APMPEE with concurrent diagnosis of gastrointestinal stromal tumor and Hurthle cell tumor. While such association may well be coincidental, the near simultaneous presentation raised our suspicion for potential association.

Metastases from Melanoma of Unknown Origin

1969 ◽  
Vol 55 (6) ◽  
pp. 403-408
Author(s):  
Natale Cascinelli ◽  
Silvana Pilotti
Keyword(s):  
Malignant Melanoma ◽  
Lymph Nodes ◽  
Primary Melanoma ◽  
Unknown Origin ◽  
Primary Site

720 cases of malignant melanoma were treated in 30 years at the Cancer Institute of Milan. In 12 of these cases the primary site of the tumor remained unknown: metastases were found 10 times in the lymph nodes, twice in the subcutis, once in the bone (rib). The incidence of occult primary melanoma is 1.6 per cent.

scholarly journals A case of S-100 negative melanoma: A diagnostic pitfall in the workup of a poorly differentiated metastatic tumor of unknown origin

CytoJournal ◽  
2016 ◽  
Vol 13 ◽  
pp. 21 ◽  
Author(s):  
Anna Biernacka ◽  
Konstantinos D. Linos ◽  
Peter A. DeLong ◽  
Arief A. Suriawinata ◽  
Vijayalakshmi Padmanabhan ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Primary Lung Cancer ◽  
Unknown Origin ◽  
Metastatic Tumor ◽  
Current Smoker ◽  
Prior History ◽  
Diagnostic Challenge ◽  
Malignant Melanomas ◽  
S 100 ◽  
Poorly Differentiated

When confronted with a metastatic poorly differentiated tumor of unknown origin, the initial workup includes the standard panel of immunostains to rule out carcinoma, sarcoma, lymphoma, and the greatest mimicker in pathology – malignant melanoma. Although not specific, the S-100 protein is expressed in over 95% of malignant melanomas. Herein, we present a case of multiorgan metastatic malignancy with a dominant hilar and mediastinal mass in a current smoker; clinically, highly suggestive of widespread primary lung cancer. This case was eventually classified as malignant melanoma, despite a significant diagnostic challenge due to lack of prior history, unusual cytomorphology, and S-100 protein negativity. A battery of immunostains was performed and the addition of other melanocytic-associated markers confirmed the melanocytic lineage of the neoplasm. This case highlights the pitfalls in the differential diagnosis of a metastatic tumor of unknown origin by fine needle aspiration cytology due to the significant morphologic overlap of poorly differentiated malignancies. We emphasize that, albeit rare, malignant melanomas can be completely negative for S-100 protein and the use of additional melanocytic-associated markers in the differential workup maybe critical in arriving promptly at a proper diagnosis. We also briefly discuss other currently available immunohistochemical markers that can assist in the identification of the S-100 negative melanoma.

scholarly journals Giant cell arteritis and polymyalgia rheumatica as first manifestation of typical pulmonary carcinoid tumor

Reumatismo ◽  
2016 ◽  
Vol 67 (4) ◽  
pp. 165 ◽  
Author(s):  
T. Aguiar ◽  
M. B. Vincent
Keyword(s):  
Giant Cell Arteritis ◽  
Giant Cell ◽  
Polymyalgia Rheumatica ◽  
Lung Tumor ◽  
Systemic Vasculitis ◽  
Hormone Secretion ◽  
Tumor Resection ◽  
Unknown Origin ◽  
Pulmonary Carcinoid ◽  
Inappropriate Antidiuretic Hormone Secretion

Giant cell arteritis (GCA), a systemic vasculitis of unknown origin, may appear rarely as a paraneoplastic syndrome. Cases secondary to pulmonary neuroendocrine tumors have not been reported. A 75-year-old female developed prednisone-responsive GCA/polymyalgia rheumatica (PMR) shortly followed by syndrome of inappropriate antidiuretic hormone secretion. An 8 mm carcinoid lung tumor with positron emission tomography normal uptake was found. After a thoracoscopic tumor resection the patient experienced complete clinical and laboratory remission. This is the first report of GCA with PMR in the context of carcinoid lung tumor. It emphasizes the role of paraneoplastic vasculitis as a possible cause of GCA.

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