Hospital admissions due to adverse drug reactions. A report from the Boston Collaborative Drug Surveillance Program

1974 ◽  
Vol 134 (2) ◽  
pp. 219-223 ◽  
Author(s):  
R. R. Miller
Keyword(s):  
Adverse Drug Reactions ◽  
Hospital Admissions ◽  
Surveillance Program ◽  
Drug Reactions ◽  
Drug Surveillance

Adverse Drug Reactions in Children Leading to Hospital Admission

PEDIATRICS ◽  
1988 ◽  
Vol 82 (1) ◽  
pp. 24-29
Author(s):  
Allen A. Mitchell ◽  
Peter G. Lacouture ◽  
Jane E. Sheehan ◽  
Ralph E. Kauffman ◽  
Samuel Shapiro
Keyword(s):  
Adverse Drug Reactions ◽  
Neonatal Intensive Care ◽  
Hospital Admissions ◽  
Teaching Hospitals ◽  
Surveillance Program ◽  
Pediatric Hospital ◽  
Drug Reactions ◽  
Drug Surveillance ◽  
Community Hospitals ◽  
Tetanus Vaccine

To provide information regarding pediatric hospital admissions prompted by adverse drug reactions, data were reviewed from an intensive drug surveillance program in which 10,297 patients admitted to diverse pediatric wards at four teaching and three community hospitals were systematically monitored. Among 3,026 neonatal intensive care unit admissions, 0.2% were prompted by adverse drug reactions; among 725 children with cancer, 22% of admissions were prompted by adverse drug reactions. Among 6,546 children with other conditions monitored on general medical and specialty wards at two teaching hospitals and on general pediatric wards at three community hospitals, 2% (131) of admissions were prompted by adverse drug reactions. Two patients (0.03%) died because of their reactions. The proportion of admissions prompted by drug reactions increased between infancy and 5 years of age and tended to be relatively stable thereafter. The drugs most commonly implicated in the admissions were phenobarbital, aspirin, phenytoin, ampicillin/amoxicillin, theophylline/aminophylline, trimethoprim-sulfamethoxazole, and diphtheria-pertussis-tetanus vaccine. Similar proportions of admissions were prompted by adverse drug reactions in teaching hospitals (2.1%) and in community hospitals (1.8%), and the drug groups implicated in these admissions were generally similar in the two settings. In contrast to adult populations, children with adverse drug reactions account for a small proportion of hospital admissions. Findings from this large, systematic study of pediatric admissions to teaching and community hospitals may serve as a baseline to which other pediatric facilities can compare their experience.

Severe adverse drug reactions of antidepressants: Results of the German Multicenter Drug Surveillance Program AMSP

2004 ◽  
Vol 36 (05) ◽  
Author(s):  
LG Schmidt ◽  
D Degner ◽  
R Grohmann ◽  
S Kropp ◽  
S Bender ◽  
...  
Keyword(s):  
Adverse Drug Reactions ◽  
Surveillance Program ◽  
Drug Reactions ◽  
Drug Surveillance

scholarly journals Urgent Hospital Admissions Caused by Adverse Drug Reactions and Medication Errors—A Population-Based Study in Spain

2020 ◽  
Vol 11 ◽  
Author(s):  
Gina Mejía ◽  
Miriam Saiz-Rodríguez ◽  
Beatriz Gómez de Olea ◽  
Dolores Ochoa ◽  
Francisco Abad-Santos
Keyword(s):  
Medication Errors ◽  
Adverse Drug Reactions ◽  
Hospital Admissions ◽  
Population Based ◽  
Drug Reactions ◽  
Population Based Study

scholarly journals An opportunity for clinical pharmacology trained physicians to improve patient drug safety: A retrospective analysis of adverse drug reactions in teenagers

F1000Research ◽  
2018 ◽  
Vol 7 ◽  
pp. 677 ◽  
Author(s):  
Andy R. Eugene ◽  
Beata Eugene
Keyword(s):  
Clinical Pharmacology ◽  
Drug Interactions ◽  
Adverse Drug Reactions ◽  
Hospital Admissions ◽  
The United States ◽  
Drug Reactions ◽  
The Third ◽  
Data Limitations ◽  
Ondansetron Hydrochloride ◽  
Improve Patient

Background: Adverse drug reactions (ADRs) are a major cause of hospital admissions, prolonged hospital stays, morbidity, and drug-related mortality. In this study, we sought to identify the most frequently reported medications and associated side effects in adolescent-aged patients in an effort to prioritize clinical pharmacology consultation efforts for hospitals seeking to improve patient safety.   Methods: Quarterly reported data were obtained from the United States Food and Drug Administration Adverse Events Reporting System (FAERS) from the third quarter of 2014 and ending in the third quarter of 2017. We then used the GeneCards database to map the pharmacogenomic biomarkers associated with the most reported FAERS drugs. Data homogenization and statistics analysis were all conducted in R for statistical programming. Results: We identified risperidone (10.64%) as the compound with the most reported ADRs from all reported cases. Males represented 90.1% of reported risperidone cases with gynecomastia being the most reported ADR. Ibuprofen OR=188 (95% CI, 105.00 – 335.00) and quetiapine fumarate OR=116 (95% CI, 48.40 – 278.00) were associated with the highest odds of completed suicide in teenagers. Ondansetron hydrochloride OR=7.12 (95% CI, 1.59 – 31.9) resulted in the highest odds of pneumothorax. Lastly, olanzapine (8.96%) represented the compound with the most reported drug-drug interactions cases, while valproic acid OR=221 (95% CI, 93.900 – 522.00) was associated with the highest odds of drug-drug interactions. Conclusion: Despite any data limitations, physicians prescribing risperidone in males should be aware of the high rates of adverse drug events and an alternative psychotropic should be considered in male patients. Further, patients with a history of pneumothorax or genetically predisposed to pneumothorax should be considered for an alternative antiemetic to ondansetron hydrochloride, due to increased odds associated with the drug and adverse event.

scholarly journals Prevalence of hospitalisation caused by adverse drug reactions at an internal medicine ward of a single centre in Japan: a cross-sectional study

BMJ Open ◽  
2019 ◽  
Vol 9 (8) ◽  
pp. e030515
Author(s):  
Junpei Komagamine ◽  
Masaki Kobayashi
Keyword(s):  
Internal Medicine ◽  
Adverse Drug Reactions ◽  
Hospital Admissions ◽  
Cross Sectional Study ◽  
Care Hospital ◽  
Sectional Study ◽  
Drug Reactions ◽  
Internal Medicine Ward ◽  
Single Centre ◽  
Cross Sectional

ObjectivesFew studies have investigated the prevalence of adverse drug reactions (ADRs) leading to hospitalisation in Japan. The aim of this study was to determine the prevalence of ADRs leading to hospitalisation and to evaluate the preventability of these ADRs in Japan.DesignA single-centre cross-sectional study using electronic medical records.SettingAcute care hospital.ParticipantsAll 1545 consecutive hospital admissions to an internal medicine ward due to acute medical illnesses from April 2017 to May 2018. The median patient age was 79 years (IQR 66–87), and the proportion of women was 47.9%.Outcome measuresThe primary outcome was the proportion of hospitalisations caused by ADRs among all hospitalisations. All suspected cases of ADRs were independently evaluated by two reviewers, and disagreements were resolved by discussion. The causality assessment for ADRs was performed by using the WHO-Uppsala Monitoring Committee criteria. The contribution of ADRs to hospitalisation and their preventability were evaluated based on the Hallas criteria.ResultsOf the 1545 hospitalisations, 153 hospitalisations (9.9%, 95% CI 8.4% to 11.4%) were caused by 200 ADRs. Cardiovascular agents (n=46, 23.0%), antithrombic agents (n=33, 16.5%), psychotropic agents (n=29, 14.5%) and non-steroidal anti-inflammatory drugs (n=24, 12.0%) accounted for approximately two-thirds of all ADRs leading to hospitalisation. Of 153 hospitalisations caused by ADRs, 102 (66.7%) were judged to be preventable.ConclusionsSimilar to other countries, one in every ten hospitalisations is caused by ADRs according to data from an internal medicine ward of a Japanese hospital. Most of these hospitalisations are preventable. Some efforts to minimise hospitalisations caused by ADRs are needed.

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