MENINGEAL GLIOMATOSIS SECONDARY TO INTRAMEDULLARY GLIOMA

✓ Previous in vitro studies have demonstrated that peripheral blood lymphocytes activated with recombinant interleukin-2 (rIL-2) generated cells that were lytic for fresh autologous tumor cells but not for normal lymphocytes or lymphoblasts. Adoptive transfer of autologous lymphokine-activated killer (LAK) cells induced in vitro with rIL-2 was used in two patients: one with meningeal gliomatosis and the other with meningeal carcinomatosis. The adoptive transfer of LAK cells was very effective in reducing the clinical symptoms and signs, and in eliminating the malignant cells from the cerebrospinal fluid. Thus, this therapy is an attractive approach for the treatment of malignant tumors that have poor immunogenicity and are insensitive to several anti-cancer agents, and for patients with severe immunosuppressive conditions induced by repeated radiation therapy or chemotherapy.

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Intrathecal chemotherapy with ACNU in a meningeal gliomatosis rat model

Journal of Neurosurgery ◽

10.3171/jns.1992.77.5.0778 ◽

1992 ◽

Vol 77 (5) ◽

pp. 778-782 ◽

Cited By ~ 3

Author(s):

T. Ken Yoshida ◽

Keiji Shimizu ◽

Athanasios Koulousakis ◽

volker sturm

Keyword(s):

Survival Time ◽

Rat Model ◽

Intrathecal Administration ◽

Intrathecal Chemotherapy ◽

C6 Glioma Cells ◽

High Dose ◽

Tumor Inoculation ◽

Content Type ◽

Meningeal Gliomatosis ◽

Rat C6 Glioma

✓ Intrathecal administration of ACNU ((1-4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride) had a remarkable chemotherapeutic effect in a rat model of meningeal gliomatosis. This effect was evaluated in rats with meningeal gliomatosis induced by an intracisternal inoculation of rat C6 glioma cells. The median survival time of the rats treated with a single dose of intrathecal ACNU (1 mg/kg) on Day 1 or Day 3 after tumor inoculation was significantly prolonged by 35.7% to 42.9% or 25.0% to 28.6%, respectively, as compared with that of the control animals. Meningeal gliomatosis rat models treated intrathecally with ACNU (1 mg/kg) 5 days after tumor inoculation or intravenously with ACNU (15 mg/kg) both failed to prolong the survival time of the animals. These findings suggest that intrathecal chemotherapy with a low dose of ACNU is effective in the early stages of meningeal gliomatosis, whereas intravenous chemotherapy with a high dose of ACNU is always ineffective.

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