Group A streptococcal sepsis and arthritis. Origin from an intrauterine device

BackgroundVarious medications have been investigated for their efficacy in pain reduction during intrauterine device (IUD) insertion, but there is currently no standard recommendation. This study aimed to investigate the efficacy of 10% lidocaine spray in reducing pain during copper-containing intrauterine device (Cu-IUD) insertion.MethodsThis study was a randomised, double-blind, placebo-controlled trial. Reproductive-age women were randomised at a 1:1 ratio into 10% lidocaine spray or placebo spray group. A 10 cm visual analogue scale (VAS) was used to evaluate pain during several steps of the IUD insertion procedure, and after the procedure.ResultsOne hundred and twenty-four women were included and 62 women were randomised in each group. Baseline characteristics between groups were similar. The 10% lidocaine spray group demonstrated significantly lower median VAS immediately after IUD insertion than the placebo group (2.95 (IQR=1.00–5.63) vs 5.00 (IQR=3.35–7.00), respectively; p=0.002). Similarly, women receiving 10% lidocaine spray reported significantly lower median VAS than those receiving placebo during tenaculum use and uterine sounding. The maximum median VAS occurred immediately after Cu-IUD insertion. The proportion of women who reported VAS≥4 during uterine sounding and after IUD placement was significantly lower in the 10% lidocaine group than in the placebo group (p<0.05). Median change in VAS from baseline to IUD placement was significantly different between 10% lidocaine spray group and placebo group (1.85 (IQR=0.08–4.03) vs 3.6 (IQR=2.40–5.80), respectively; p=0.004).Conclusion10% lidocaine spray was found to be an effective local anaesthetic method for reducing pain during insertion of Cu-IUD.Trial registration numberClinicaltrials.gov NCT03870711

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Meta-analysis of genes within QTLs of group A streptococcal sepsis and their expression QTLs reveal pathways modulating host differential response to streptococcal sepsis

BMC Bioinformatics ◽

10.1186/1471-2105-13-s12-a6 ◽

2012 ◽

Vol 13 (Suppl 12) ◽

pp. A6

Author(s):

Nourtan Abdeltawab ◽

Lu Lu ◽

Robert Williams ◽

Malak Kotb

Keyword(s):

Meta Analysis ◽

Differential Response ◽

Group A ◽

Streptococcal Sepsis

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Group A Streptococcal Sepsis Secondary to Acute Salpingitis

Clinical Infectious Diseases ◽

10.1093/clind/16.3.444 ◽

1993 ◽

Vol 16 (3) ◽

pp. 444-445 ◽

Cited By ~ 6

Author(s):

W. B. Barham ◽

R. L. Haberberger ◽

C. F. Decker

Keyword(s):

Group A ◽

Streptococcal Sepsis

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Postabortal Group A Streptococcal Sepsis and Toxic Shock Syndrome

Infectious Diseases in Obstetrics and Gynecology ◽

10.1155/s1064744997000331 ◽

1997 ◽

Vol 5 (3) ◽

pp. 210-210

Author(s):

David E. Soper

Keyword(s):

Toxic Shock Syndrome ◽

Toxic Shock ◽

Group A ◽

Streptococcal Sepsis

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A case of puerperal group a streptococcal sepsis complicated by ovarian vein thrombosis

Journal of Obstetrics and Gynaecology ◽

10.1080/01443615.2016.1174831 ◽

2016 ◽

Vol 36 (7) ◽

pp. 857-858

Author(s):

Makiko Egawa ◽

Naoyuki Miyasaka ◽

Takuyuki Kubo ◽

Miho Naitou ◽

Takashi Ito ◽

...

Keyword(s):

Ovarian Vein ◽

Vein Thrombosis ◽

Group A ◽

Streptococcal Sepsis ◽

Ovarian Vein Thrombosis

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Levonorgestrel Intrauterine System Effects versus Copper Intrauterine Device on Changing Of Menstruation and Uterine Artery Doppler

Gynecology and Women’s Health Care ◽

10.47485/2766-5879.1004 ◽

2020 ◽

Keyword(s):

Uterine Artery ◽

Intrauterine Device ◽

Hormonal Contraceptive ◽

University Hospitals ◽

Uterine Artery Doppler ◽

Uterine Arteries ◽

Group A ◽

Irregular Bleeding ◽

Doppler Indices ◽

Copper Intrauterine Device

Background: The most effective methods for birth control are the long-acting reversible contraceptives LARCs include Paragard IUD in silver, Mirena IUD in hormonal (progesterone) and hormonal contraceptive implant. The intrauterine levonorgestrel-releasing system (LNG-IUS) and the intrauterine copper unit (Cu-IUD) influenced changing of menstruation and uterine artery Doppler indices Aim of the work: Comparison of the effects of copper intrauterine device (Cu-IUD) and an intrauterine levonorgestrel releasing system (LNG-IUS) on changing of menstruation and Doppler indices of uterine arteries. Methods: This was RCT was completed between February 2017 to January 2020 at the Obstetrics and Gynecology department, Tanta University hospitals. There were two group first group A :LNG-IUS (N=200) and second group B CuIUD (N=200), they were randomly assigned to 400 multiparous women preferring intrauterine contraception., the UA pulsatility index (PI) and the resistant index (RI) were determined at the beginning, and the associations with irregular bleeding were evaluated three and six months after insertion. Results: In group A: LNG-IUS, some women registered irregular bleeding (28 percent) than in the Cu-IUD group (52 percent) at the beginning of the study (P<0.001). There was bleeding irregularity (73 percent) in the group (A): LNG-IUS and severe menstrual bleeding (68 percent) in the Cu-IUD group. The uterine artery PI was associated with bleeding irregularity at value of 1.40, with a curve area (AUC) of 0.91, 90 percent sensitivity, and 100 percent specificity. Uterine artery RI was associated with 0.65 with 0.22 AUC bleeding irregularity, 95 percent sensitivity and accuracy 100 percent. Conclusion: LNG - IUS related irregular bleeding was linked to changes in the blood flow of uterine arteries that were not evident among Cu - IUD users.

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