scholarly journals Outcomes of Cardiopulmonary Resuscitation in Patients With COVID-19—Limited Data, but Further Reason for Action

Author(s):  
Matthew E. Modes ◽  
Robert Y. Lee ◽  
J. Randall Curtis
Author(s):  
Glenn Goodwin, D.O., EMT-P, RN-BSN ◽  
Tarik Zeid, D.O. ◽  
Todd Belok, D.O.

The resource-limiting environment of the pre-hospital setting necessitates the continuous development of tools and interventions that maximise the capabilities of emergency medical services (EMS) municipalities. One such product developed by Zoll, the ResQCPR system, attempts to enhance the effectiveness of prehospital cardiopulmonary resuscitation (CPR). The ResQCPR system is comprised of the ResQPOD, which is an impedance threshold device (ITD), and the ResQPUMP, which is an assisted compression-decompression (ACD) device. Limited data exists regarding Zoll’s specific apparatuses as well as similar such devices. This systematic analysis comprehensively summarises a number of related studies. Their methods, limitations, results, and other aspects are outlined in the respective sections. Conclusion: This review concludes by determining that the effectiveness of the ResQPUMP, in particular (and ACD devices in general), is promising while the ResQPOD’s is uncertain. Future studies are needed to determine whether the effectiveness of the ResQPUMP markedly diminishes when used independently of the ResQPOD. This is an important feature for fire departments and other EMS municipalities because outfitting all appropriate units with both devices can be quite costly. Further studies are also needed to demonstrate reproducibility in humans (because 2 of the studies used pigs as test subjects) and with a greater amount of test subjects.


2020 ◽  
Vol 9 (11) ◽  
pp. 3588
Author(s):  
Ik Hyun Park ◽  
Jeong Hoon Yang ◽  
Woo Jin Jang ◽  
Woo Jung Chun ◽  
Ju Hyeon Oh ◽  
...  

Limited data are available on the association between low-flow time and survival in patients with in-hospital cardiac arrest (IHCA) who undergo extracorporeal cardiopulmonary resuscitation (ECPR). We evaluated data from 183 IHCA patients who underwent ECPR as a rescue procedure. Patients were divided into two groups: patients undergoing extracorporeal membrane oxygenation as an adjunct to standard cardiopulmonary resuscitation for less than 38 min (n = 110) or for longer than 38 min (n = 73). The ECPR ≤ 38 min group had a significantly greater incidence of survival to discharge compared to the ECPR > 38 min group (40.0% versus 24.7%, p = 0.032). The incidence of good neurologic outcomes at discharge tended to be greater in the ECPR ≤ 38 min group than in the ECPR > 38 min group (35.5% versus 24.7%, p = 0.102). The incidences of limb ischemia (p = 0.354) and stroke (p = 0.805) were similar between the two groups, but major bleeding occurred less frequently in the ECPR ≤ 38 min group compared to the ECPR > 38 min group (p = 0.002). Low-flow time ≤ 38 min may reduce the risk of mortality and fatal neurologic damage and could be a measure of optimal management in patients with IHCA.


1999 ◽  
Vol 173 ◽  
pp. 289-293 ◽  
Author(s):  
J.R. Donnison ◽  
L.I. Pettit

AbstractA Pareto distribution was used to model the magnitude data for short-period comets up to 1988. It was found using exponential probability plots that the brightness did not vary with period and that the cut-off point previously adopted can be supported statistically. Examination of the diameters of Trans-Neptunian bodies showed that a power law does not adequately fit the limited data available.


VASA ◽  
2014 ◽  
Vol 43 (1) ◽  
pp. 55-61 ◽  
Author(s):  
Konstantinos Tziomalos ◽  
Vasilios Giampatzis ◽  
Stella Bouziana ◽  
Athinodoros Pavlidis ◽  
Marianna Spanou ◽  
...  

Background: Peripheral arterial disease (PAD) is frequently present in patients with acute ischemic stroke. However, there are limited data regarding the association between ankle brachial index (ABI) ≤ 0.90 (which is diagnostic of PAD) or > 1.40 (suggesting calcified arteries) and the severity of stroke and in-hospital outcome in this population. We aimed to evaluate these associations in patients with acute ischemic stroke. Patients and methods: We prospectively studied 342 consecutive patients admitted for acute ischemic stroke (37.4 % males, mean age 78.8 ± 6.4 years). The severity of stroke was assessed with the National Institutes of Health Stroke Scale (NIHSS)and the modified Rankin scale (mRS) at admission. The outcome was assessed with the mRS and dependency (mRS 2 - 5) at discharge and in-hospital mortality. Results: An ABI ≤ 0.90 was present in 24.6 % of the patients whereas 68.1 % had ABI 0.91 - 1.40 and 7.3 % had ABI > 1.40. At admission, the NIHSS score did not differ between the 3 groups (10.4 ± 10.6, 8.3 ± 9.3 and 9.3 ± 9.4, respectively). The mRS score was also comparable in the 3 groups (3.6 ± 1.7, 3.1 ± 1.8 and 3.5 ± 2.3, respectively). At discharge, the mRS score did not differ between the 3 groups (2.9 ± 2.2, 2.3 ± 2.1 and 2.7 ± 2.5, respectively) and dependency rates were also comparable (59.5, 47.6 and 53.3 %, respectively). In-hospital mortality was almost two-times higher in patients with ABI ≤ 0.90 than in patients with ABI 0.91 - 1.40 or > 1.40 but this difference was not significant (10.9, 6.6 and 6.3 %, respectively). Conclusions: An ABI ≤ 0.90 or > 1.40 does not appear to be associated with more severe stroke or worse in-hospital outcome in patients with acute ischemic stroke.


1993 ◽  
Vol 11 (3) ◽  
pp. 529-535 ◽  
Author(s):  
Rita F. Redberg ◽  
Kelly Tucker ◽  
Nelson B. Schiller

BDJ ◽  
1992 ◽  
Vol 173 (5) ◽  
pp. 173-174 ◽  
Author(s):  
I Hussain ◽  
R W Matthews ◽  
C Scully

2010 ◽  
Vol 30 (03) ◽  
pp. 150-155 ◽  
Author(s):  
J. W. Wang ◽  
J. Eikenboom

SummaryVon Willebrand factor (VWF) is a pivotal haemostatic protein mediating platelet adhesion to injured endothelium and carrying coagulation factor VIII (FVIII) in the circulation to protect it from premature clearance. Apart from the roles in haemostasis, VWF drives the formation of the endothelial cell specific Weibel-Palade bodies (WPBs), which serve as a regulated storage of VWF and other thrombotic and inflammatory factors. Defects in VWF could lead to the bleeding disorder von Willebrand disease (VWD).Extensive studies have shown that several mutations identified in VWD patients cause an intracellular retention of VWF. However, the effects of such mutations on the formation and function of its storage organelle are largely unknown. This review gives an overview on the role of VWF in WPB biogenesis and summarizes the limited data on the WPBs formed by VWD-causing mutant VWF.


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