Loop diuretics for acute kidney injury in adults and children

2012 ◽  
Author(s):  
Watanyu Parapiboon ◽  
Chavasak Kanokkantapong ◽  
Malinee Laopaiboon ◽  
Pisake Lumbiganon ◽  
Apichat Sangchan
Keyword(s):  
Acute Kidney Injury ◽  
Kidney Injury ◽  
Loop Diuretics ◽  
Adults And Children

Loop diuretics for acute kidney injury in adults and children

2011 ◽  
Author(s):  
Watanyu Parapiboon ◽  
Chavasak Kanokkantapong ◽  
Malinee Laopaiboon ◽  
Pisake Lumbiganon ◽  
Apichat Sangchan
Keyword(s):  
Acute Kidney Injury ◽  
Kidney Injury ◽  
Loop Diuretics ◽  
Adults And Children

scholarly journals Loop Diuretics in Acute Kidney Injury Prevention, Therapy, and Risk Stratification

2019 ◽  
Vol 44 (4) ◽  
pp. 457-464 ◽  
Author(s):  
Daniel Patschan ◽  
Susann Patschan ◽  
Ivo Buschmann ◽  
Oliver Ritter
Keyword(s):  
Acute Kidney Injury ◽  
Stress Test ◽  
Kidney Injury ◽  
Renal Perfusion ◽  
Diagnostic Value ◽  
Loop Diuretics ◽  
Kidney Dysfunction ◽  
Volume Depletion ◽  
Prevention Therapy ◽  
Clinical Consequences

Background: Loop diuretics (LD) are widely used in emergency and intensive care medicine. Summary: The substances increase the clearance of electrolytes and water; thus, they allow us to control hypervolemia and to prevent patients from pulmonary edema. LD are also frequently applied to patients with an acute decrease in glomerular filtration rate, namely, acute kidney injury (AKI). Nevertheless, volume depletion may be associated with reduced renal perfusion and possibly slower restitution or even aggravation of kidney dysfunction. Several trials on the preventive or therapeutic efficacy of LD have been published since the early 1970s. Our review article is intended to summarize the most important references related to this topic. In addition, we discuss the diagnostic value of the so-called furosemide stress test. The currently available data indicate that LD may act in a beneficial manner as long as euvolemia is maintained (matched hydration). Key Massages: LD are not beneficial for AKI treatment if kidney-related endpoints are considered. In certain situations, AKI prevention with LD can be associated with favorable outcomes as long as euvolemia is maintained. LD can help to identify AKI subjects at a higher risk of AKI progression, but the exact clinical consequences need to be determined.

scholarly journals A Review on the Application and Limitations of Administrative Health Care Data for the Study of Acute Kidney Injury Epidemiology and Outcomes in Children

2021 ◽  
Vol 9 ◽  
Author(s):  
Emma H. Ulrich ◽  
Gina So ◽  
Michael Zappitelli ◽  
Rahul Chanchlani
Keyword(s):  
Health Care ◽  
Acute Kidney Injury ◽  
Administrative Data ◽  
Health Research ◽  
Validation Studies ◽  
Large Scale ◽  
Kidney Injury ◽  
Process Of Care ◽  
Data Repositories ◽  
Adults And Children

Administrative health care databases contain valuable patient information generated by health care encounters. These “big data” repositories have been increasingly used in epidemiological health research internationally in recent years as they are easily accessible and cost-efficient and cover large populations for long periods. Despite these beneficial characteristics, it is also important to consider the limitations that administrative health research presents, such as issues related to data incompleteness and the limited sensitivity of the variables. These barriers potentially lead to unwanted biases and pose threats to the validity of the research being conducted. In this review, we discuss the effectiveness of health administrative data in understanding the epidemiology of and outcomes after acute kidney injury (AKI) among adults and children. In addition, we describe various validation studies of AKI diagnostic or procedural codes among adults and children. These studies reveal challenges of AKI research using administrative data and the lack of this type of research in children and other subpopulations. Additional pediatric-specific validation studies of administrative health data are needed to promote higher volume and increased validity of this type of research in pediatric AKI, to elucidate the large-scale epidemiology and patient and health systems impacts of AKI in children, and to devise and monitor programs to improve clinical outcomes and process of care.

Loop Diuretics in Acute Kidney Injury

2012 ◽  
pp. 1337-1341
Author(s):  
James W. Davis ◽  
Dana Forman ◽  
La Scienya M. Jackson ◽  
James W. Davis ◽  
Javier Garau ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Kidney Injury ◽  
Loop Diuretics

scholarly journals Incidence and Risk Factors for Acute Kidney Injury during the Treatment of Methicillin-Sensitive Staphylococcus aureus Infections with Cloxacillin Based Antibiotic Regimens: A French Retrospective Study

2021 ◽  
Vol 10 (12) ◽  
pp. 2603
Author(s):  
Romain Crochette ◽  
Camille Ravaiau ◽  
Lucia Perez ◽  
Jean-Philippe Coindre ◽  
Giorgina Barbara Piccoli ◽  
...  
Keyword(s):  
Risk Factors ◽  
Staphylococcus Aureus ◽  
Acute Kidney Injury ◽  
Retrospective Study ◽  
Kidney Injury ◽  
Loop Diuretics ◽  
Inclusion Criteria ◽  
Medical Department ◽  
Factors Associated ◽  
Aureus Infection

Background: Cloxacillin has been associated with the occurrence of acute kidney injury (AKI). The incidence of this complication in the literature is low (2.5–3.5%) and probably underestimated, since most studies were done by selecting the presence of AKI in discharge codes. Objectives: The primary goal was to define the incidence of AKI in patients with a methicillin-sensitive Staphylococcus aureus infection treated with cloxacillin based antibiotic regimens. The secondary goals were to identify the risk factors associated with this complication and to describe the characteristics of AKI. Patients and methods: We carried out a retrospective study. The inclusion criteria were adult patients hospitalized in a medical department at the Le Mans Hospital between 1 July 2012 and 1 July 2019 with a diagnosis of methicillin-sensitive Staphylococcus aureus infection treated with cloxacillin. Results: One hundred twenty-three patients were included in the study. Forty-two patients (34.2%) developed AKI. In the multivariate analysis, age, the use of diuretics and the presence of endocarditis were independently associated with AKI. Age was associated with an OR of 4.38 (p = 0.002) for patients older than 75, being treated with diuretics was associated with an OR of 2.94 (p = 0.036) for loop diuretics and an OR of 3.05 (p = 0.027) for non-loop diuretics; type of infection was associated with an OR of 3.42 (p = 0.012) for endocarditis. Conclusions: The occurrence of AKI is frequent during cloxacillin based antibiotic regimens for methicillin-sensitive Staphylococcus aureus infections. Being older than 75, being treated with diuretics and the presence of endocarditis were the main risk factors for AKI in our population.

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