Hierarchically Structured Porous Materials-Applications in Biochemistry: Bioceramics, Life Science, and Drug Delivery

Metal–organic frameworks (MOFs), as a prominent category of hybrid porous materials constructed from metal clusters or ions plus organic linkers, have been broadly employed as controlled systems of drug delivery...

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MOF Decomposition and Introduction of Repairable Defects Using a Photodegradable Strut

10.26434/chemrxiv.7081151.v1 ◽

2018 ◽

Author(s):

Jingjing Yan ◽

John MacDonald ◽

Shawn Burdette

Keyword(s):

Drug Delivery ◽

Porous Materials ◽

New Method ◽

Innovative Approach ◽

Partial Decomposition ◽

Multiple Defects ◽

Potential Applications ◽

Defect Repair ◽

First Time ◽

Interesting Area

Utilizing a photolabile ligand as MOF strut can make a framework undergo full or partial decomposition upon irradiation. For the first time, a nitrophenylacetate derivative has been incorporated into MOF as a backbone linker via PLSE method. The photo-induced decarboxylation of the NPDAC-MOF represents a novel way of degrading a MOF, which provides an innovative approach to formulating photoresponsive porous materials with potential applications in molecular release and drug delivery. When photoactive linker is mixed with non-photolabile linker via partial PLSE, the MOF structure can be retained after irradiation, but with the introduction of multiple defects, offering a new method to create vacancies in MOFs. Defect repair can be achieved by treatment with replacement ligands, the scope of which is an interesting area for developing customizable MOF contents.<br>

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Insights into Hierarchically Structured Porous Materials: From Nanoscience to Catalysis, Separation, Optics, Energy, and Life Science

Hierarchically Structured Porous Materials ◽

10.1002/9783527639588.ch1 ◽

2011 ◽

pp. 1-27 ◽

Cited By ~ 1

Author(s):

Bao-Lian Su ◽

Clément Sanchez ◽

Xiao-Yu Yang

Keyword(s):

Porous Materials ◽

Life Science

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Low pressure mediated enhancement of nanoparticle and macromolecule loading into porous silicon structures

Open Material Sciences ◽

10.2478/mesbi-2014-0002 ◽

2014 ◽

Vol 1 (1) ◽

Cited By ~ 3

Author(s):

Fransisca Leonard ◽

Katherine Margulis ◽

Xuewu Liu ◽

Srimeenakshi Srinivasan ◽

Shlomo Magdassi ◽

...

Keyword(s):

Drug Delivery ◽

Porous Materials ◽

Biomedical Applications ◽

Pore Diameter ◽

Drug Loading ◽

Low Pressure ◽

Contrast Imaging ◽

Therapeutic Molecules ◽

Silicon Structures ◽

The Difference

AbstractEnsuring drug loading efficiency and consistency is one of the most critical stages in engineering drug delivery vectors based on porous materials. Here we propose a technique to significantly enhance the effciency of loading by employing simple and widely available methods: applying low pressure with and without centrifugation. Our results point toward the advantages of the proposed method over the passive loading, especially when the difference between the dimensions of loaded materials and the pore diameter is small, an increase of up to 20-fold can be observed. The technique described in this study can be used for efficient and reproducible loading of porous materials with therapeutic molecules, nanoparticles and contrast imaging agents for biomedical applications.

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Recent Developments in the Synthesis and Applications of Metal Organic Framework: A Concise Review

Asian Journal of Chemistry ◽

10.14233/10.14233/ajchem.2021.23055 ◽

2021 ◽

Vol 33 (5) ◽

pp. 956-962

Author(s):

Chandan Adhikari ◽

Rehana Farooq

Keyword(s):

Drug Delivery ◽

Porous Materials ◽

Electrochemical Sensors ◽

Metal Organic Framework ◽

Metal Organic Frameworks ◽

Inorganic Materials ◽

Synthetic Methods ◽

Concise Review ◽

Metal Organic ◽

Organic Framework

Metal organic frameworks (MOFs) are one of those compounds which have drawn attention in various applications due to their several interesting properties like tunable shape, size, pore size, easy functionalization, high surface area, pore volume, etc. Metal organic frameworks due to their uniform structures, tunable porosity, wide variety and stability on various topology, geometry, dimension and chemical functions of the molecular network give a remarkable structural diversity in comparison to other porous materials. This enables scientists to handle numerous framework structures, porosity and functionality effectively. The unique structural architecture and tunable properties of MOF’s makes them an interesting hybrid material consisting of organic and inorganic materials. MOF can be randomly constructed like Lego bricks and superior in terms of versatility in comparisson to other porous materials. A number of MOFs containing a wide variety of metal e.g. zinc, copper, iron, aluminium, magnesium, chromium, zirconium, gadolinium, manganese are gaining rapid growth in commercial markets for gas storage, adsorption, separation and catalytic applications. This concise review emphasizes various synthetic methods e.g. solvothermal process, hydrothermal synthesis, electrochemical synthesis, microwave synthesis, sonochemical synthesis, mechanochemical synthesis, of metal organic framework developed in the last few decades. It also addresses various applications of metal organic framework e.g. hydrogen storage, gas adsorption, drug delivery systems and bioimaging agents, biocatalysts, biosensors, electrochemical sensors, etc. It also comments on various challenges and futuristic applications of metal organic frameworks in various field e.g. liquid wate management, gaseous waste management, sunlight assisted catalysis, water purification, building materials, electronic devices, battery technologies, targeted drug delivery, solar cells, etc. of science and technology in coming decades.

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Recent advances in Fe-MOF compositions for in biomedical applications

Current Medicinal Chemistry ◽

10.2174/0929867328666210511014129 ◽

2021 ◽

Vol 28 ◽

Author(s):

Yuyu Zhong ◽

Weicong Liu ◽

Congying Rao ◽

Baohong Li ◽

Xiaoxiong Wang ◽

...

Keyword(s):

Drug Delivery ◽

Porous Materials ◽

Antibacterial Agent ◽

Biomedical Applications ◽

Drug Delivery Systems ◽

Biomedical Application ◽

Metal Organic Frameworks ◽

Medical Applications ◽

Future Perspectives ◽

Metal Organic

Background: To date, a number of new and attractive materials have been applied in drug delivery systems (DDDs) to improve the efficiency of the treatment of cancers. Some problems like low stability, toxicity, and weak ability of targeting have hampered most of the materials for further applications in biomedicine. MIL(MIL = Materials of Institute Lavoisier), as a typical subclass of metal-organic frameworks (MOFs), owns more advantages than other subclass MOFs, such as better biodegradability and lower cytotoxicity. However, until now, systematic conclusions and analyses of Fe-based MIL on medical applications are rare, even though the majority of documents have discussed one research branch of the porous materials MOFs. Discussion: In this review, we're going to focus mainly on the latest studies of applications, including bioimaging, biosensing, and antibacterial and drug delivery on Fe-based MIL. The existing shortcomings and future perspectives of the rapidly growing biomedical applications of Fe-based MIL materials addressing dosage and loading strategies issues are also discussed briefly.. Further studies with the use of different therapies will be of great interest. Conclusion: This article reviews the Fe-based MOFs design and biomedical application, including biosensing, bioimaging, antibacterial agent, and drug delivery in recent years.

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Selective host–guest interactions in metal–organic frameworks via multiple hydrogen bond donor–acceptor recognition sites

Journal of Materials Chemistry A ◽

10.1039/c8ta12190g ◽

2019 ◽

Vol 7 (17) ◽

pp. 10379-10388 ◽

Cited By ~ 8

Author(s):

T. Wittmann ◽

C. B. L. Tschense ◽

L. Zappe ◽

C. Koschnick ◽

R. Siegel ◽

...

Keyword(s):

Drug Delivery ◽

Hydrogen Bond ◽

Porous Materials ◽

Metal Organic Frameworks ◽

Hydrogen Bond Donor ◽

Recognition Sites ◽

Molecular Separation ◽

Multiple Hydrogen Bond ◽

Donor Acceptor ◽

Metal Organic

Targeted recognition of medium sized molecules with mixed hydrogen bond units is essential for using porous materials for molecular separation, sensing and drug delivery.

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MIL-53(Fe), MIL-101, and SBA-15 porous materials: Potential platforms for drug delivery

Materials Science and Engineering C ◽

10.1016/j.msec.2014.11.046 ◽

2015 ◽

Vol 47 ◽

pp. 172-179 ◽

Cited By ~ 56

Author(s):

Jeff Gordon ◽

Hossein Kazemian ◽

Sohrab Rohani

Keyword(s):

Drug Delivery ◽

Porous Materials

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Drug Delivery Applications of Three-Dimensional Printed (3DP) Mesoporous Scaffolds

Pharmaceutics ◽

10.3390/pharmaceutics12090851 ◽

2020 ◽

Vol 12 (9) ◽

pp. 851 ◽

Cited By ~ 1

Author(s):

Tania Limongi ◽

Francesca Susa ◽

Marco Allione ◽

Enzo di Fabrizio

Keyword(s):

Drug Delivery ◽

Porous Materials ◽

Mesoporous Materials ◽

Molecular Sieves ◽

Materials Science ◽

Bone Cells ◽

Three Dimensional ◽

Fused Deposition ◽

Wide Range ◽

Drug Delivery Applications

Mesoporous materials are structures characterized by a well-ordered large pore system with uniform porous dimensions ranging between 2 and 50 nm. Typical samples are zeolite, carbon molecular sieves, porous metal oxides, organic and inorganic porous hybrid and pillared materials, silica clathrate and clathrate hydrates compounds. Improvement in biochemistry and materials science led to the design and implementation of different types of porous materials ranging from rigid to soft two-dimensional (2D) and three-dimensional (3D) skeletons. The present review focuses on the use of three-dimensional printed (3DP) mesoporous scaffolds suitable for a wide range of drug delivery applications, due to their intrinsic high surface area and high pore volume. In the first part, the importance of the porosity of materials employed for drug delivery application was discussed focusing on mesoporous materials. At the end of the introduction, hard and soft templating synthesis for the realization of ordered 2D/3D mesostructured porous materials were described. In the second part, 3DP fabrication techniques, including fused deposition modelling, material jetting as inkjet printing, electron beam melting, selective laser sintering, stereolithography and digital light processing, electrospinning, and two-photon polymerization were described. In the last section, through recent bibliographic research, a wide number of 3D printed mesoporous materials, for in vitro and in vivo drug delivery applications, most of which relate to bone cells and tissues, were presented and summarized in a table in which all the technical and bibliographical details were reported. This review highlights, to a very cross-sectional audience, how the interdisciplinarity of certain branches of knowledge, as those of materials science and nano-microfabrication are, represent a growing valuable aid in the advanced forum for the science and technology of pharmaceutics and biopharmaceutics.

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