Circuit Elements Based on Enzyme Systems

2019 ◽  
pp. 151-173
Keyword(s):  
Enzyme Systems ◽  
Circuit Elements

THE INFLUENCE OF 17α-METHYL-19-NORTESTOSTERONE (M. N. T.) ON THE METABOLISM OF CORTISOL

1962 ◽  
Vol 39 (1) ◽  
pp. 22-31 ◽  
Author(s):  
A. Vermeulen ◽  
J. Ferin
Keyword(s):  
Urinary Excretion ◽  
Liver Enzyme ◽  
Chromatographic Analysis ◽  
Inactivation Rate ◽  
Chromatographic Study ◽  
List Type ◽  
Cortisol Metabolism ◽  
Enzyme Systems ◽  
Corticosterone Metabolites ◽  
Cortisol Metabolites

ABSTRACT The effect of prolonged 17α-methyl-nortestosterone (M. N. T.) administration on cortisol metabolism was studied in several patients. 1. A decreased urinary excretion of 17-hydroxycorticosteroids occurred regularly. 2. Chromatographic analysis of the urinary corticoids revealed that the decreased urinary excretion involved exclusively cortisol metabolites, whereas corticosterone metabolites were excreted at normal levels. This chromatographic study moreover showed an impairment in the conjugation of tetrahydrocorticoids. 3. Studies with 4-14C-cortisol in MNT treated patients showed increased transcortin levels, a normal cortisol pool, a reduced cortisol inactivation rate and a decreased cortisol production. 4. From these results it is concluded that the decreased 17-hydroxycorticoid excretion reflects a decreased cortisol production, at least partly secondary to a reduced cortisol-inactivation rate, which itself must be attributable either to an inhibition or a defect in the liver enzyme systems concerned in corticoid-inactivation.

scholarly journals Enzyme Systems in the Mycobacteria

1962 ◽  
Vol 237 (11) ◽  
pp. 3332-3338
Author(s):  
Dexter S. Goldman ◽  
Frank A. Lornitzo
Keyword(s):  
Enzyme Systems

scholarly journals ENZYME SYSTEMS IN TETRAHYMENA GELEII S

1951 ◽  
Vol 191 (1) ◽  
pp. 439-446
Author(s):  
Gerald R. Seaman
Keyword(s):  
Enzyme Systems
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