scholarly journals Anisometric Microstructures to Determine Minimal Critical Physical Cues Required for Neurite Alignment

2021 ◽  
pp. 2100874
Author(s):  
Sitara Vedaraman ◽  
Amaury Perez‐Tirado ◽  
Tamas Haraszti ◽  
Jose Gerardo‐Nava ◽  
Akihiro Nishiguchi ◽  
...  
Keyword(s):  
Physical Cues

scholarly journals Physical cues of cell culture materials lead the direction of differentiation lineages of pluripotent stem cells

2015 ◽  
Vol 3 (41) ◽  
pp. 8032-8058 ◽  
Author(s):  
Akon Higuchi ◽  
Qing-Dong Ling ◽  
S. Suresh Kumar ◽  
Yung Chang ◽  
Abdullah A. Alarfaj ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cell Culture ◽  
Pluripotent Stem Cells ◽  
Specific Cell ◽  
Cell Lineages ◽  
Physical Cues

Differentiation methods of hPSCs into specific cell lineages. Differentiation of hPSCsviaEB formation (types AB, A–D) or without EB formation (types E–H).

Development of Ethnic Awareness in the Absence of Physical Cues

1982 ◽  
Vol 5 (2) ◽  
pp. 109-127 ◽  
Author(s):  
Liz McWhirter ◽  
Roberta Gamble
Keyword(s):  
Physical Cues

scholarly journals Cellular orientation is guided by strain gradients

2017 ◽  
Vol 9 (7) ◽  
pp. 607-618 ◽  
Author(s):  
Sophie Chagnon-Lessard ◽  
Hubert Jean-Ruel ◽  
Michel Godin ◽  
Andrew E. Pelling
Keyword(s):  
Long Range ◽  
Strain Gradients ◽  
Physical Cues

A biomimetic microdevice reveals that strain gradients act as potent physical cues which guide the long-range organization of cells.

scholarly journals Tuning cell migration: contractility as an integrator of intracellular signals from multiple cues

F1000Research ◽  
2016 ◽  
Vol 5 ◽  
pp. 1819 ◽  
Author(s):  
Francois Bordeleau ◽  
Cynthia A. Reinhart-King
Keyword(s):  
Cell Migration ◽  
Growth Factors ◽  
Three Dimensional ◽  
Two Dimensional ◽  
Multiple Cues ◽  
Cell Contractility ◽  
Cell Matrix ◽  
Intracellular Signals ◽  
Physical Cues ◽  
The Matrix

There has been immense progress in our understanding of the factors driving cell migration in both two-dimensional and three-dimensional microenvironments over the years. However, it is becoming increasingly evident that even though most cells share many of the same signaling molecules, they rarely respond in the same way to migration cues. To add to the complexity, cells are generally exposed to multiple cues simultaneously, in the form of growth factors and/or physical cues from the matrix. Understanding the mechanisms that modulate the intracellular signals triggered by multiple cues remains a challenge. Here, we will focus on the molecular mechanism involved in modulating cell migration, with a specific focus on how cell contractility can mediate the crosstalk between signaling initiated at cell-matrix adhesions and growth factor receptors.

scholarly journals The Extracellular Matrix and Pancreatic Cancer: A Complex Relationship

Cancers ◽  
2018 ◽  
Vol 10 (9) ◽  
pp. 316 ◽  
Author(s):  
Maximilian Weniger ◽  
Kim Honselmann ◽  
Andrew Liss
Keyword(s):  
Extracellular Matrix ◽  
Therapeutic Strategies ◽  
Ductal Adenocarcinoma ◽  
Interstitial Tissue ◽  
Complex Relationship ◽  
Tumor Perfusion ◽  
Tissue Pressure ◽  
Physical Cues ◽  
Proliferation And Metastasis ◽  
Mechanical Influence

Pancreatic ductal adenocarcinoma (PDAC) has an extraordinarily dense fibrotic stroma that impedes tumor perfusion and delivery of anticancer drugs. Since the extracellular matrix (ECM) comprises the bulk of the stroma, it is primarily responsible for the increased interstitial tissue pressure and stiff mechanical properties of the stroma. Besides its mechanical influence, the ECM provides important biochemical and physical cues that promote survival, proliferation, and metastasis. By serving as a nutritional source, the ECM also enables PDAC cells to survive under the nutrient-poor conditions. While therapeutic strategies using stroma-depleting drugs have yielded disappointing results, an increasing body of research indicates the ECM may offer a variety of potential therapeutic targets. As preclinical studies of ECM-targeted drugs have shown promising effects, a number of clinical trials are currently investigating agents with the potential to advance the future treatment of PDAC. Thus, the present review seeks to give an overview of the complex relationship between the ECM and PDAC.

Engaging Organisational Culture to Overcome Social Barriers in Virtual Communites

2011 ◽  
pp. 193-197
Author(s):  
Anzela Huq
Keyword(s):  
Information Systems ◽  
Virtual Work ◽  
Organisational Culture ◽  
Initial Trust ◽  
Social Barriers ◽  
Face To Face ◽  
Physical Cues ◽  
Physical Limitations ◽  
Recent Trends ◽  
Space Distance

Recent trends in the technical development of information systems and their implementation have influenced academics to focus on specific aspects, particularly those systems that enhance and support organisational communication under physical limitations. The purpose of these ICTs is to bring together parties who are separated by those factors and allow them to collaborate and communicate for the purposes of their work without actually feeling the effect of time and distance. These tools have particular use for virtual organisations that operate in environments that are undefined physically in terms of space and time, yet allow information and knowledge to flow freely, therefore bridging the gap that is experienced by space, distance, and time. In traditional methods of face-to-face work, people are able to see and feel one another, factors that although may not seem so obviously important to begin with, are actually essential to cooperation and collaboration, because it is based on these physical cues that people begin to form the basic impressions and opinions upon which they base their trust of one another (Kreijns, Kirschner, & Jochems, 2003). Within the context of virtual work, particularly where people have never met, the basis for initial trust is missing and it seems that the success of working in virtual environments, or lack thereof, is fundamentally due to this.

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