To improve the utilization rate of visible light in the degradation of the dye wastewater, the supported mesoporous TiO2 catalyst with perlite as the carrier was prepared. The effect of the calcination time and the loading time on the degradation of the methylene blue by the catalyst was analyzed. The result showed that: as the calcination time exceeded 1.5h, the catalyst activity decreased with the calcination time increasing; under the condition of the optimal calcination time of 1.5h, the degradation rate of methylene blue by visible light reached 71.59%; the multi-loading was in favor of increasing the catalyst activity, of which 3-time loading was the optimal.