Identifying adolescent and young adult patients with sickle cell disease at highest risk of death

2020 ◽  
Vol 96 (1) ◽  
pp. 9-11
Author(s):  
Mark T. Gladwin ◽  
Gregory J. Kato ◽  
Victor R. Gordeuk
Keyword(s):  
Young Adult ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Adult Patients ◽  
Adolescent And Young Adult ◽  
Cell Disease ◽  
Risk Of Death

scholarly journals Pulmonary hypertension in sickle cell disease: diagnosis and management

Hematology ◽  
2014 ◽  
Vol 2014 (1) ◽  
pp. 425-431 ◽  
Author(s):  
Kenneth I. Ataga ◽  
Elizabeth S. Klings
Keyword(s):  
Pulmonary Hypertension ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Disease Diagnosis ◽  
Adult Patients ◽  
Heart Catheterization ◽  
Cell Disease ◽  
Risk Of Death ◽  
Increased Risk ◽  
High Prevalence

Abstract The increased survival of patients with sickle cell disease (SCD) into adulthood is associated with an increased incidence of multiorgan dysfunction and a progressive systemic and pulmonary vasculopathy. The high prevalence of an elevated tricuspid regurgitant jet velocity and its association with an increased risk of death in adult patients is well established. However, there has been controversy regarding the prevalence of pulmonary hypertension (PH) and its association with mortality in SCD. Multiple recently published reports demonstrate that PH as diagnosed by right heart catheterization is common in adult SCD patients, with a prevalence of 6%–11%. Furthermore, PH is associated with an increased risk of death in SCD patients. In this chapter, we provide evidence for the high prevalence of PH in SCD and its association with mortality and make recommendations for its evaluation and management. Finally, we provide the rationale for screening for this life-threatening complication in adult patients with SCD.

Cognitive functioning in young adult patients with sickle cell disease

2013 ◽  
Vol 81 (S1) ◽  
pp. 14-14
Author(s):  
Marleen Raterink ◽  
Veronica van der Land ◽  
Karin Fijnvandraat ◽  
Ben Schmand
Keyword(s):  
Young Adult ◽  
Sickle Cell Disease ◽  
Cognitive Functioning ◽  
Sickle Cell ◽  
Adult Patients ◽  
Cell Disease

scholarly journals Evidence for complement-mediated bone marrow necrosis in a young adult with sickle cell disease

2021 ◽  
Vol 86 ◽  
pp. 102508
Author(s):  
Melissa Azul ◽  
Surbhi Shah ◽  
Sarah Williams ◽  
Gregory M. Vercellotti ◽  
Alexander A. Boucher
Keyword(s):  
Bone Marrow ◽  
Young Adult ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Cell Disease ◽  
Bone Marrow Necrosis
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