scholarly journals Higher coffee consumption is associated with slower cognitive decline and Aβ‐amyloid accumulation over 126 months: Data from the AIBL study

2021 ◽  
Vol 17 (S10) ◽  
Author(s):  
Samantha L Gardener ◽  
Stephanie R Rainey‐Smith ◽  
Victor LL Villemagne ◽  
Jurgen Fripp ◽  
Vincent Dore ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Coffee Consumption ◽  
Amyloid Accumulation ◽  
Aβ Amyloid

scholarly journals Higher Coffee Consumption Is Associated With Slower Cognitive Decline and Less Cerebral Aβ-Amyloid Accumulation Over 126 Months: Data From the Australian Imaging, Biomarkers, and Lifestyle Study

2021 ◽  
Vol 13 ◽  
Author(s):  
Samantha L. Gardener ◽  
Stephanie R. Rainey-Smith ◽  
Victor L. Villemagne ◽  
Jurgen Fripp ◽  
Vincent Doré ◽  
...  
Keyword(s):  
Older Adults ◽  
Cognitive Decline ◽  
Protective Factor ◽  
Coffee Consumption ◽  
Imaging Biomarkers ◽  
Coffee Intake ◽  
Cognitively Normal ◽  
Amyloid Accumulation ◽  
Aβ Amyloid ◽  
The Relationship

Background: Worldwide, coffee is one of the most popular beverages consumed. Several studies have suggested a protective role of coffee, including reduced risk of Alzheimer’s disease (AD). However, there is limited longitudinal data from cohorts of older adults reporting associations of coffee intake with cognitive decline, in distinct domains, and investigating the neuropathological mechanisms underpinning any such associations.Methods: The aim of the current study was to investigate the relationship between self-reported habitual coffee intake, and cognitive decline assessed using a comprehensive neuropsychological battery in 227 cognitively normal older adults from the Australian Imaging, Biomarkers, and Lifestyle (AIBL) study, over 126 months. In a subset of individuals, we also investigated the relationship between habitual coffee intake and cerebral Aβ-amyloid accumulation (n = 60) and brain volumes (n = 51) over 126 months.Results: Higher baseline coffee consumption was associated with slower cognitive decline in executive function, attention, and the AIBL Preclinical AD Cognitive Composite (PACC; shown reliably to measure the first signs of cognitive decline in at-risk cognitively normal populations), and lower likelihood of transitioning to mild cognitive impairment or AD status, over 126 months. Higher baseline coffee consumption was also associated with slower Aβ-amyloid accumulation over 126 months, and lower risk of progressing to “moderate,” “high,” or “very high” Aβ-amyloid burden status over the same time-period. There were no associations between coffee intake and atrophy in total gray matter, white matter, or hippocampal volume.Discussion: Our results further support the hypothesis that coffee intake may be a protective factor against AD, with increased coffee consumption potentially reducing cognitive decline by slowing cerebral Aβ-amyloid accumulation, and thus attenuating the associated neurotoxicity from Aβ-amyloid-mediated oxidative stress and inflammatory processes. Further investigation is required to evaluate whether coffee intake could be incorporated as a modifiable lifestyle factor aimed at delaying AD onset.

P4-031 Moderate coffee consumption is associated with a less rapid cognitive decline in elderly men. The fine study

2004 ◽  
Vol 25 ◽  
pp. S481
Author(s):  
Boukje M. van Gelder ◽  
Brian Buijsse ◽  
Sandra Kalmijn ◽  
Marja Tijhuis ◽  
Simona Giampaoli ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Coffee Consumption ◽  
Elderly Men ◽  
Rapid Cognitive Decline

scholarly journals Patterns of cognitive decline and somatosensory processing in a mouse model of amyloid accumulation

2021 ◽  
pp. 100076
Author(s):  
Olivia Uddin ◽  
Keiko Arakawa ◽  
Charles Raver ◽  
Brendan Garagusi ◽  
Asaf Keller
Keyword(s):  
Mouse Model ◽  
Cognitive Decline ◽  
Somatosensory Processing ◽  
Amyloid Accumulation

scholarly journals Association of CSF Aβ, amyloid PET, and cognition in cognitively unimpaired elderly adults

Neurology ◽  
2020 ◽  
Vol 95 (15) ◽  
pp. e2075-e2085 ◽  
Author(s):  
Tengfei Guo ◽  
Leslie M. Shaw ◽  
John Q. Trojanowski ◽  
William J. Jagust ◽  
Susan M. Landau ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Amyloid Pet ◽  
Elderly Adults ◽  
Cognitively Normal ◽  
Longitudinal Measurements ◽  
Normal Individuals ◽  
Aβ Amyloid ◽  
Discordant Group ◽  
Amyloid Aβ ◽  
The Relationship

ObjectiveTo compare CSF β-amyloid (Aβ) and florbetapir PET measurements in cognitively unimpaired (CU) elderly adults in order to detect the earliest abnormalities and compare their predictive effect for cognitive decline.MethodsA total of 259 CU individuals were categorized as abnormal (+) or normal (−) on CSF Aβ1-42/Aβ1-40 analyzed with mass spectrometry and Aβ PET measured with 18F-florbetapir. Simultaneous longitudinal measurements of CSF and PET were compared for 39 individuals who were unambiguously Aβ-negative at baseline (CSF−/PET−). We also examined the relationship between baseline CSF/PET group membership and longitudinal changes in CSF Aβ, Aβ PET, and cognition.ResultsThe proportions of individuals in each discordant group were similar (8.1% CSF+/PET− and 7.7% CSF−/PET+). Among baseline Aβ-negative (CSF−/PET−) individuals with longitudinal CSF and PET measurements, a larger proportion subsequently worsened on CSF Aβ (odds ratio 4 [95% confidence interval (CI) 1.1, 22.1], p = 0.035) than Aβ PET over 3.5 ± 1.0 years. Compared to CSF−/PET− individuals, CSF+/PET− individuals had faster (estimate 0.009 [95% CI 0.005, 0.013], p < 0.001) rates of Aβ PET accumulation over 4.4 ± 1.7 years, while CSF−/PET+ individuals had faster (estimate −0.492 [95% CI −0.861, −0.123], p = 0.01) rates of cognitive decline over 4.5 ± 1.9 years.ConclusionsThe proportions of discordant PET and CSF Aβ-positive individuals were similar cross-sectionally. However, unambiguously Aβ-negative (CSF−/PET−) individuals are more likely to show subsequent worsening on CSF than PET, supporting the idea that CSF detects the earliest Aβ changes. In discordant cases, only PET abnormality predicted cognitive decline, suggesting that abnormal Aβ PET changes are a later phenomenon in cognitively normal individuals.

BDNF Val66Met, Aβ amyloid, and cognitive decline in preclinical Alzheimer's disease

2013 ◽  
Vol 34 (11) ◽  
pp. 2457-2464 ◽  
Author(s):  
Yen Ying Lim ◽  
Victor L. Villemagne ◽  
Simon M. Laws ◽  
David Ames ◽  
Robert H. Pietrzak ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Decline ◽  
Preclinical Alzheimer’S Disease ◽  
Aβ Amyloid

scholarly journals Coffee consumption is inversely associated with cognitive decline in elderly European men: the FINE Study

2006 ◽  
Vol 61 (2) ◽  
pp. 226-232 ◽  
Author(s):  
B M van Gelder ◽  
B Buijsse ◽  
M Tijhuis ◽  
S Kalmijn ◽  
S Giampaoli ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Coffee Consumption

scholarly journals P4-485: SPON1 IS ASSOCIATED WITH Aβ-AMYLOID AND APOE ε4 RELATED COGNITIVE DECLINE IN COGNITIVELY NORMAL ADULTS

2019 ◽  
Vol 15 ◽  
pp. P1498-P1498
Author(s):  
Tenielle Porter ◽  
Samantha C. Burnham ◽  
Lidija Milicic ◽  
Greg Savage ◽  
Paul Maruff ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Cognitively Normal ◽  
Apoe Ε4 ◽  
Aβ Amyloid ◽  
Normal Adults
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