Advanced Sugar Chemistry. Principles of Sugar Stereochemistry. Von R. S. Shallenberger. Ellis Horwood Ltd., Chichester 1982. XX, 323 S., geb. £ 31.50

2006 ◽  
Vol 95 (9) ◽  
pp. 761-762
Author(s):  
Hans Paulsen
Keyword(s):  
Sugar Chemistry ◽  
Sugar Stereochemistry

scholarly journals Synthesis, Formulation, and Adjuvanticity of Monodesmosidic Saponins with Olenanolic Acid, Hederagenin and Gypsogenin Aglycones, and some C-28 Ester Derivatives

2020 ◽  
Author(s):  
BW Greatrex ◽  
Alison Daines ◽  
S Hook ◽  
DH Lenz ◽  
W McBurney ◽  
...  
Keyword(s):  
Mhc Class Ii ◽  
Self Assembly ◽  
Vaccine Adjuvant ◽  
Choline Ester ◽  
Activation Markers ◽  
Murine Bone Marrow ◽  
Transmission Electron ◽  
High Concentrations ◽  
Sugar Stereochemistry

© 2015 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. In an attempt to discover a new synthetic vaccine adjuvant, the glycosylation of hederagenin, gypsogenin, and oleanolic acid acceptors with di- and trisaccharide donors to generate a range of mimics of natural product QS-21 was carried out. The saponins were formulated with phosphatidylcholine and cholesterol, and the structures analyzed by transmission electron microscopy. 3-O-(Manp(1→3)Glcp)hederagenin was found to produce numerous ring-like micelles when formulated, while C-28 choline ester derivatives preferred self-assembly and did not interact with the liposomes. When alone and in the presence of cholesterol and phospholipid, the choline ester derivatives produced nanocrystalline rods or helical micelles. The effects of modifying sugar stereochemistry and the aglycone on the immunostimulatory effects of the saponins was then evaluated using the activation markers MHC class II and CD86 in murine bone marrow dendritic cells. The most active saponin, 3-O-(Manp(1→3)Glcp)hederagenin, was stimulatory at high concentrations in cell culture, but this did not translate to strong responses in vivo.

Glycosyl Bunte Salts: A Class of Intermediates for Sugar Chemistry

2017 ◽  
Vol 20 (1) ◽  
pp. 76-79 ◽  
Author(s):  
Yasuhiro Meguro ◽  
Masato Noguchi ◽  
Gefei Li ◽  
Shin-ichiro Shoda
Keyword(s):  
Sugar Chemistry ◽  
Bunte Salts

A novel reductive fragmentation reaction in thio-sugar chemistry

1998 ◽  
Vol 39 (24) ◽  
pp. 4267-4270 ◽  
Author(s):  
L. Brochard ◽  
C. Lorin ◽  
N. Spiess ◽  
P. Rollin
Keyword(s):  
Fragmentation Reaction ◽  
Sugar Chemistry

Sugar Chemistry.

1951 ◽  
Vol 43 (4) ◽  
pp. 804-808
Author(s):  
W. D. Horne ◽  
S. M. Cantor ◽  
R. W. Liggett
Keyword(s):  
Sugar Chemistry
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