Autocrine‐Based Selection of Drugs That Target Ion Channels from Combinatorial Venom Peptide Libraries

2016 ◽  
Vol 128 (32) ◽  
pp. 9452-9456
Author(s):  
Hongkai Zhang ◽  
Mingjuan Du ◽  
Jia Xie ◽  
Xiao Liu ◽  
Jingying Sun ◽  
...  
Keyword(s):  
Ion Channels ◽  
Peptide Libraries ◽  
Venom Peptide ◽  
Selection Of

Autocrine‐Based Selection of Drugs That Target Ion Channels from Combinatorial Venom Peptide Libraries

2016 ◽  
Vol 55 (32) ◽  
pp. 9306-9310 ◽  
Author(s):  
Hongkai Zhang ◽  
Mingjuan Du ◽  
Jia Xie ◽  
Xiao Liu ◽  
Jingying Sun ◽  
...  
Keyword(s):  
Ion Channels ◽  
Peptide Libraries ◽  
Venom Peptide ◽  
Selection Of

scholarly journals Titelbild: Autocrine‐Based Selection of Drugs That Target Ion Channels from Combinatorial Venom Peptide Libraries (Angew. Chem. 32/2016)

2016 ◽  
Vol 128 (32) ◽  
pp. 9245-9245
Author(s):  
Hongkai Zhang ◽  
Mingjuan Du ◽  
Jia Xie ◽  
Xiao Liu ◽  
Jingying Sun ◽  
...  
Keyword(s):  
Ion Channels ◽  
Peptide Libraries ◽  
Venom Peptide ◽  
Selection Of

scholarly journals Cover Picture: Autocrine‐Based Selection of Drugs That Target Ion Channels from Combinatorial Venom Peptide Libraries (Angew. Chem. Int. Ed. 32/2016)

2016 ◽  
Vol 55 (32) ◽  
pp. 9099-9099
Author(s):  
Hongkai Zhang ◽  
Mingjuan Du ◽  
Jia Xie ◽  
Xiao Liu ◽  
Jingying Sun ◽  
...  
Keyword(s):  
Ion Channels ◽  
Peptide Libraries ◽  
Venom Peptide ◽  
Selection Of

Superposition properties of independent ion channels

1989 ◽  
Vol 238 (1291) ◽  
pp. 155-170 ◽  
Keyword(s):  
Ion Channels ◽  
Sojourn Time ◽  
Single Channel ◽  
Stochastic Modelling ◽  
Multiple Channels ◽  
Channel Activity ◽  
Channel System ◽  
Distributional Properties ◽  
Multichannel Systems ◽  
Selection Of

Membrane patches usually contain several ion channels of a given type. However, most of the stochastic modelling on which data analysis (in particular, estimation of kinetic constants) is currently based, relates to a single channel rather than to multiple channels. Attempts to circumvent this problem experimentally by recording under conditions where channel activity is low are restrictive and can introduce bias; moreover, possibly important information on how multichannel systems behave will be missed. We have extended existing theory to multichannel systems by applying results from point process theory to derive some distributional properties of the various types of sojourn time that occur when a given number of channels are open in a system containing a specified number of independent channels in equilibrium. Separate development of properties of a single channel and the superposition of several such independent channels simplifies the presentation of known results and extensions. To illustrate the general theory, particular attention is given to the types of sojourn time that occur in a two channel system; detailed expressions are presented for a selection of models, both Markov and non-Markov.

scholarly journals Novel random peptide libraries displayed on AAV serotype 9 for selection of endothelial cell-directed gene transfer vectors

Gene Therapy ◽  
2011 ◽  
Vol 19 (8) ◽  
pp. 800-809 ◽  
Author(s):  
K Varadi ◽  
S Michelfelder ◽  
T Korff ◽  
M Hecker ◽  
M Trepel ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Gene Transfer ◽  
Peptide Libraries ◽  
Random Peptide ◽  
Random Peptide Libraries ◽  
Transfer Vectors ◽  
Selection Of

scholarly journals Genetically Encoded Libraries of Nonstandard Peptides

2012 ◽  
Vol 2012 ◽  
pp. 1-15 ◽  
Author(s):  
Takashi Kawakami ◽  
Hiroshi Murakami
Keyword(s):  
Amino Acids ◽  
Genetic Code ◽  
Posttranslational Modifications ◽  
Biological Properties ◽  
Peptide Libraries ◽  
Universal Genetic Code ◽  
Nonsense Codons ◽  
Genetic Code Expansion ◽  
Diagnostic Applications ◽  
Selection Of

The presence of a nonproteinogenic moiety in a nonstandard peptide often improves the biological properties of the peptide. Non-standard peptide libraries are therefore used to obtain valuable molecules for biological, therapeutic, and diagnostic applications. Highly diverse non-standard peptide libraries can be generated by chemically or enzymatically modifying standard peptide libraries synthesized by the ribosomal machinery, using posttranslational modifications. Alternatively, strategies for encoding non-proteinogenic amino acids into the genetic code have been developed for the direct ribosomal synthesis of non-standard peptide libraries. In the strategies for genetic code expansion, non-proteinogenic amino acids are assigned to the nonsense codons or 4-base codons in order to add these amino acids to the universal genetic code. In contrast, in the strategies for genetic code reprogramming, some proteinogenic amino acids are erased from the genetic code and non-proteinogenic amino acids are reassigned to the blank codons. Here, we discuss the generation of genetically encoded non-standard peptide libraries using these strategies and also review recent applications of these libraries to the selection of functional non-standard peptides.

Rapid Combinatorial Screening of Peptide Libraries for the Selection of Lanthanide-Binding Tags (LBTs)

2005 ◽  
Vol 24 (10) ◽  
pp. 1149-1157 ◽  
Author(s):  
Langdon J. Martin ◽  
Bianca R. Sculimbrene ◽  
Mark Nitz ◽  
Barbara Imperiali
Keyword(s):  
Peptide Libraries ◽  
Combinatorial Screening ◽  
Lanthanide Binding Tags ◽  
Selection Of
Sign in / Sign up

Export Citation Format

Share Document