Asymmetric Palladium‐Catalyzed Oxycarbonylation of Terminal Alkenes: Efficient Access to β‐Hydroxy Alkylcarboxylic Acids

2021 ◽  
Author(s):  
Guosheng Liu ◽  
Bin Tian ◽  
Xiang Li ◽  
Pinhong Chen
Keyword(s):  
Efficient Access ◽  
Terminal Alkenes ◽  
Palladium Catalyzed

Sequential C-Selective Difluoromethylation/Pd-Catalyzed Decarboxylative Protonation: An Efficient Access to Tertiary Difluoromethylated Scaffolds

2019 ◽  
Author(s):  
Nicolas Duchemin ◽  
Roberto Buccafusca ◽  
Marc Daumas ◽  
Vincent Ferey ◽  
Stellios Arseniyadis
Keyword(s):  
Drug Development ◽  
Late Stage ◽  
Efficient Access ◽  
Palladium Catalyzed ◽  
General Method

We report here a general method that allows a highly straightforward access to tertiary difluoromethylated compounds. The strategy relies on a two-step sequence featuring a C-selective electrophilic difluoromethylation and an unprecedented palladium-catalyzed decarboxylative protonation. Considering the generality of the method and the attractive properties offered by the difluoromethyl group, this approach provides a valuable tool for late-stage functionalization and drug development.<br>

scholarly journals Palladium-catalyzed 1,1-alkynylbromination of alkenes with alkynyl bromides

2021 ◽  
Author(s):  
Yusuke Ano ◽  
Natsuki Kawai ◽  
Naoto Chatani
Keyword(s):  
Diverse Range ◽  
Terminal Alkenes ◽  
Palladium Catalyzed

The palladium-catalyzed 1,1-alkynylbromination of terminal alkenes with a silyl-protected alkynyl bromide is reported. The method tolerates a diverse range of alkenes including vinylarenes, acrylates, and even electronically unbiased alkene derivatives...

Palladium-catalyzed cross-dehydrogenative-coupling of nitro-substituted internal alkenes with terminal alkenes

2021 ◽  
pp. 153396
Author(s):  
Yunlong Li ◽  
Haibo Liu ◽  
Zilong Huang ◽  
Hongmei Wang ◽  
Zhengkun Yu
Keyword(s):  
Dehydrogenative Coupling ◽  
Terminal Alkenes ◽  
Palladium Catalyzed

Palladium-catalyzed C(sp2)–H aminoimidoylation of isocyano-containing arenes: synthesis of amino substituted N-heterocycles

2017 ◽  
Vol 4 (9) ◽  
pp. 1768-1771 ◽  
Author(s):  
Zhuang Xiong ◽  
Jian Wang ◽  
Yanbo Wang ◽  
Shuang Luo ◽  
Qiang Zhu
Keyword(s):  
Efficient Access ◽  
Palladium Catalyzed ◽  
Isoquinoline Derivatives

An efficient access to amino substituted phenanthridine and isoquinoline derivatives, through palladium-catalyzed C(sp2)–H aminoimidoylation, has been developed.

Palladium-Catalyzed Regioselective Direct C-H Bond Alkoxycarbonylation of 2-Arylimidazo[1,2-a]pyridines

2021 ◽  
Author(s):  
Ebrahim Kianmehr ◽  
Arezoo Tanbakouchian
Keyword(s):  
Efficient Access ◽  
Palladium Catalyzed

A palladium-catalyzed practical and efficient access to alkoxycarbonylated imidazo[1,2-a]pyridines at C-3 position has been developed relaying on the association of W(CO)6 as a safe and easy to handle CO surrogate...

Monodentate Phosphorus Ligand-Enabled General Palladium-Catalyzed Allylic C–H Alkylation of Terminal Alkenes

2019 ◽  
Vol 21 (17) ◽  
pp. 6720-6725 ◽  
Author(s):  
Lian-Feng Fan ◽  
Pu-Sheng Wang ◽  
Liu-Zhu Gong
Keyword(s):  
Terminal Alkenes ◽  
Palladium Catalyzed

scholarly journals Palladium-catalyzed hydroalkylation of methylenecyclopropanes with simple hydrazones

2020 ◽  
Vol 11 (39) ◽  
pp. 10759-10763
Author(s):  
Jinzhong Yao ◽  
Zhangpei Chen ◽  
Lin Yu ◽  
Leiyang Lv ◽  
Dawei Cao ◽  
...  
Keyword(s):  
Functional Group ◽  
Bond Scission ◽  
Terminal Alkenes ◽  
Palladium Catalyzed ◽  
High Yields

A palladium-catalyzed hydroalkylation of methylenecyclopropanes via selective C–C σ-bond scission was achieved, in which simple hydrazones served as carbanion equivalents. This method affords high yields of C-alkylated terminal alkenes with good functional group compatibility.

Secondary Phosphine Oxide Preligands for Palladium-Catalyzed C-H (Hetero)Arylations: Efficient Access to Pybox Ligands

2017 ◽  
Vol 359 (18) ◽  
pp. 3137-3141 ◽  
Author(s):  
Debasish Ghorai ◽  
Valentin Müller ◽  
Helena Keil ◽  
Dietmar Stalke ◽  
Giuseppe Zanoni ◽  
...  
Keyword(s):  
Phosphine Oxide ◽  
Secondary Phosphine ◽  
Efficient Access ◽  
Palladium Catalyzed
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