Determination of the molecular conformation of β-D-O2,2′-cyclouridine in aqueous solution by proton magnetic resonance spectroscopy

Biopolymers ◽  
1973 ◽  
Vol 12 (10) ◽  
pp. 2381-2389 ◽  
Author(s):  
Bradford P. Cross ◽  
Thomas Schleich
Keyword(s):  
Aqueous Solution ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Proton Magnetic Resonance ◽  
Proton Magnetic Resonance Spectroscopy ◽  
Molecular Conformation ◽  
Resonance Spectroscopy

Accurate Determination of Concentrations by Localized Proton Magnetic Resonance Spectroscopy

2007 ◽  
Vol 36 (1) ◽  
pp. 71-80 ◽  
Author(s):  
Nashiely Pineda Alonso ◽  
Hubert Desal ◽  
Evelyne Baguet ◽  
Frederique Toulgoat ◽  
Serge Akoka
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Proton Magnetic Resonance ◽  
Proton Magnetic Resonance Spectroscopy ◽  
Accurate Determination ◽  
Resonance Spectroscopy

Determination of Enantiomeric Purity of Tranylcypromine Sulfate by Proton Magnetic Resonance Spectroscopy with Chiral Lanthanide Shift Reagent

1989 ◽  
Vol 72 (4) ◽  
pp. 552-555
Author(s):  
George M Hanna ◽  
Cesar A Lau-Cam
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Proton Magnetic Resonance ◽  
Proton Magnetic Resonance Spectroscopy ◽  
Optical Purity ◽  
Enantiomeric Purity ◽  
Molar Ratio ◽  
Resonance Spectroscopy ◽  
Lanthanide Chelate

Abstract Optimum experimental conditions were developed for determination of the optical purity of samples of tranylcypromine sulfate by proton magnetic resonance spectroscopy after complexation with the chiral lanthanide chelate Eu(hfc).3. At a substrate concentration of 0.25M (0.125M as sulfate) in CDC13 and an Eu(hfc)3 to substrate molar ratio of 1, the methine proton geminal to the amino group in the cyclopropane ring showed the largest induced shift and largest enantiomeric induced shift difference. From the relative intensities of the resolved (+)-CH-NH2 protons (15.77 ppm) and (-)-CH-NH2 proton (16.04 ppm), the enantiomeric purity and percentage compositions were readily calculated. The mean ± SD recovery of (+)- tranylcypromine sulfate from synthetic enantiomeric mixtures was 101.02 ± 2.59 (n = 6).

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