Effect of chemically bonded stationary phases and mobile phase composition onβ-blockers retention in RP-HPLC

2009 ◽  
Vol 23 (3) ◽  
pp. 324-333 ◽  
Author(s):  
Boguslaw Buszewski ◽  
Tomasz Welerowicz ◽  
Tomasz Kowalkowski
Keyword(s):  
Phase Composition ◽  
Mobile Phase ◽  
Stationary Phases ◽  
Mobile Phase Composition ◽  
Bonded Stationary Phases ◽  
Rp Hplc

The effect of mobile phase composition in the enantioseparation of pharmaceutically relevant compounds with polysaccharide-based stationary phases

2013 ◽  
Vol 28 (1) ◽  
pp. 159-167 ◽  
Author(s):  
Roccaldo Sardella ◽  
Federica Ianni ◽  
Antonella Lisanti ◽  
Maura Marinozzi ◽  
Stefania Scorzoni ◽  
...  
Keyword(s):  
Phase Composition ◽  
Mobile Phase ◽  
Stationary Phases ◽  
Mobile Phase Composition

scholarly journals Quantitative estimation of trimazolin hydrochloride in pharmaceutical preparation by RP-HPLC method

2009 ◽  
Vol 63 (2) ◽  
pp. 87-93 ◽  
Author(s):  
Ivana Savic ◽  
Goran Nikolic ◽  
Vladimir Bankovic ◽  
Ivan Savic
Keyword(s):  
Phase Composition ◽  
Quantitative Determination ◽  
Mobile Phase ◽  
Quantitative Estimation ◽  
Pharmaceutical Preparation ◽  
Hplc Method ◽  
Mobile Phase Composition ◽  
Rp Hplc ◽  
Ich Guidelines

A sensitive and selective RP-HPLC method was developed and validated for the quantitative determination of trimazolin hydrochloride in nasal drops formulations. The mobile phase composition was water-acetonitrile (50:50, v/v) and the UV detection was carried out at 270 nm. Linearity range in the concentration range of 10 to 110 ?g cm-3. The method was tested and validated for various parameters according to ICH guidelines. The detection and quantization limits were found to be 1.45 and 4.8 ?g cm-3, respectively. The results demonstrated that the procedure for estimation of trimazolin hydrochloride in nasal drops formulations was accurate, precise and reproducible.

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