An investigation of standard compounds for evaluating instrument performance in positive ion and negative ion chemical ionization mass spectrometry

1983 ◽  
Vol 10 (2) ◽  
pp. 103-106 ◽  
Author(s):  
Steven J. Stout ◽  
Stanley J. Cardaciotto ◽  
William G. Millen
Keyword(s):  
Mass Spectrometry ◽  
Chemical Ionization ◽  
Negative Ion ◽  
Ionization Mass Spectrometry ◽  
Chemical Ionization Mass Spectrometry ◽  
Ionization Mass ◽  
Instrument Performance ◽  
Negative Ion Chemical Ionization ◽  
Positive Ion

Confirmatory Method for Sulfonamide Residues in Animal Tissues by Gas Chromatography and Pulsed Positive Ion-Negative Ion-Chemical Ionization Mass Spectrometry

1993 ◽  
Vol 76 (5) ◽  
pp. 976-982 ◽  
Author(s):  
Andrê E Mooser ◽  
Herbert Koch
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Chemical Ionization ◽  
Negative Ion ◽  
Ionization Mass Spectrometry ◽  
Chemical Ionization Mass Spectrometry ◽  
Ionization Mass ◽  
Methyl Derivative ◽  
Negative Ion Chemical Ionization ◽  
Positive Ion

Abstract A confirmatory method has been developed for determination of 13 sulfonamides in edible tissues. The assay involves extraction from a solution resulting from a screening procedure by liquid chromatography and subsequent derivatization. Sulfachloropyridazine (SCP), sulfadiazine (SDA), sulfadimethoxine (SDM), sulfamethazine (SMZ), sulfamerazine (SME), sulfamethoxazole (SMX), sulfamethoxypyridazine (SMP), sulfapyridine (SPR), sulfaquinoxaline (SQX), and sulfathiazole (STA) were detected as the N1-methyl-N4-trifluoroacetyl derivatives, sulfaguanidine (SGU) as the same derivative after cyclization by hexafluoroacetylacetone, and sulfacetamide (SAC) as the methyl derivative. These sulfonamides were detected by gas chromatography and pulsed positive ion-negative ion-chemical ionization mass spectrometry with methane as the reactant gas, whereas sulfanilamide (SAA) was determined as the methyl derivative by electron-impact ionization.

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