scholarly journals Modeling‐Assisted Design of Thermostable Benzaldehyde Lyases from Rhodococcus erythropolis for Continuous Production of α‐Hydroxy Ketones

ChemBioChem ◽  
2021 ◽  
Author(s):  
Martin Peng ◽  
Dominik L. Siebert ◽  
Martin K. M. Engqvist ◽  
Christof M. Niemeyer ◽  
Kersten S. Rabe
Keyword(s):  
Continuous Production ◽  
Rhodococcus Erythropolis ◽  
Hydroxy Ketones

scholarly journals Modeling‐assisted Design of Thermostable Benzaldehyde Lyases from Rhodococcus erythropolis for Continuous Production of α‐Hydroxy Ketones

ChemBioChem ◽  
2021 ◽  
Author(s):  
Martin Peng ◽  
Dominik L. Siebert ◽  
Martin K. M. Engqvist ◽  
Christof M. Niemeyer ◽  
Kersten S. Rabe
Keyword(s):  
Continuous Production ◽  
Rhodococcus Erythropolis ◽  
Hydroxy Ketones

Fungicidal and Bactericidal Activity of the Alkyl-Substituted Guanidine-Containing Oligomers

2020 ◽  
Vol 82 (6) ◽  
pp. 54-63
Author(s):  
M.Ya. Vortman ◽  
◽  
Yu.B. Pysmenna ◽  
A.I. Chuenko ◽  
D.R. Abdulina ◽  
...  
Keyword(s):  
Heterotrophic Bacteria ◽  
Trichoderma Viride ◽  
Rhodococcus Erythropolis ◽  
Biological Action ◽  
Molar Ratio ◽  
Diffusion Method ◽  
Klebsiella Pneumonia ◽  
Alkyl Bromides ◽  
Base Form ◽  
Two Stages

Biocides are widely used in medicine and various industries to protect against a number of harmful microorganisms. Organic quaternary ammonium and guanidine-containing compounds, the biological action of which is based on membrane-toxic properties, are used as bactericidal preparations. The aim of this work was to study the bactericidal and fungicidal activities of the synthesized oligomeric alkylsubstituted guanidinium bromides with different radicals -C3H7, -C7H15, -C10H21, against different isolates of heterotrophic bacteria and microscopic fungi. Methods. The synthesis of alkyl-substituted guanidiniumcontaining oligomers was performed in two stages. In the first stage, alkyl-substituted guanidine was obtained by the reaction of guanidine, previously converted by alkali from the salt form to the base form by the base and alkyl bromides (Alk=-C3H7 (propyl), -C7H15 (heptyl), -C10H21 (decyl)) in methanol at a temperature of 50°C and a molar ratio of 1:1. The second carried out the reaction between aromatic oligoepoxide DER-331 and alkyl-substituted guanidine in methanol at a temperature of 50°C for 2–3 hours and a molar ratio of 1:2. Bacteria were grown on meat-peptone agar for 48 hours at a temperature of 28±2°С. Test cultures of micromycetes were cultured on agar beer wort (6°B), incubated for 14 days in a thermostat at a temperature of 28±2°C. Antimicrobial activity of newly synthesized alkyl-substituted guanidinium-containing oligomers was determined by standard disco-diffusion method (method of disks on agar) and fungicidal activity was determined by the method of holes in agar. Results. Oligomeric alkylsubstituted guanidinium bromides with different radicals composed -C3H7, -C7H15, -C10H21- synthesized by the reaction of guanidine alkyl bromides with aromatic oligoepoxydes. It was found that alkyl-substituted guanidinium-containing oligomers at a concentration of 1–3% inhibited the growth of Escherichia coli 475, Pseudomonas aeruginosa 465, Klebsiella pneumonia 479, Pseudomonas pseudoalcaligenes 109, Staphylococcus aureus 451, E. faecalis 422, Rhodococcus erythropolis 102, Bacillus subtilis 138 and most of the studied micromycetes – Aureobasidium pullulans F-41430, Paecilomyces variotii F-41432, Penicillium funiculosum F-41435, Penicillium ochrochloron F-41431, Scopulariopsis brevicaulis F-41434, Trichoderma viride F-41437, Candida albicans F-41441, Aspergillus flavus F-41442, Aspergillus niger F-41448, Penicillium sp. F-41447. Conclusions. Antimicrobial and fungicidal properties significantly depend on the length of the alkyl radical, with increasing of its length the diameter of the zone of bacterial and micromycetes growth retardation increases.10.15407/microbiolj82.06.054

OPERATION OF EQUIPMENT IN CONTINUOUS PRODUCTION

2020 ◽  
Author(s):  
Сергей Ильдусович Валеев
Keyword(s):  
Continuous Production ◽  
Subsequent Development

В работе проведен анализ возможной эксплуатации сосудов и аппаратов с дефектами типа расслоение. Установлено, что эксплуатация оборудования возможна только с последующей разработкой мероприятий, позволяющих повысить уровень безопасности. The paper analyzes the possible operation of vessels and apparatuses with defects of the stratification type. It was established that the operation of the equipment is possible only with the subsequent development of measures to increase the level of safety.

Respect for the Environment is Part of Competitiveness - Best Available Technology Applied to an Old Pulp Mill at Kaskinen

1999 ◽  
Vol 40 (11-12) ◽  
pp. 201-206
Author(s):  
I. Reilama ◽  
N. Ilomäki
Keyword(s):  
Process Development ◽  
Continuous Production ◽  
Production Capacity ◽  
Pulp Mill ◽  
Process Technology ◽  
Line Production ◽  
Nutrient Emissions ◽  
Best Available Technology ◽  
Available Technology ◽  
Process Solutions

Oy Metsä-Botnia Ab's Kaskinen mill produces ECF and TCF bleached softwood and hardwood pulp on a single continuous production line. Production capacity has been raised from 250,000 tonnes to 420,000 tonnes a year after the commission in 1977. The basic process solutions date mainly from the 1970s. However, process technology has been gradually modernised. With systematic and well-timed process development investments the mill has remained competitive and among frontrunners in terms of environmental protection. Today, Kaskinen represent the best available technology (BAT) applicable to old mills. Effluent loading in general and nutrient emissions in particular has diminished during the development projects of the mill. Comparison to other mills shows that as far as effluent emissions are concerned, Kaskinen is one of the best pulp mills in Finland and Scandinavia. In this presentation, Kaskinen is also compared to Metsä-Rauma, the first greenfield TCF mill in the world, which was started up in 1996. Kaskinen's pioneering work on TCF technology was used as a basis for process solutions in the Rauma greenfield project.

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