ChemInform Abstract: A Convenient One-Pot Synthesis of Secondary Amines via Aza-Wittig Reaction.

ChemInform ◽  
2010 ◽  
Vol 23 (41) ◽  
pp. no-no
Author(s):  
T. GAJDA ◽  
A. KOZIARA ◽  
K. OSOWSKA-PACEWICKA ◽  
S. ZAADZKI ◽  
A. ZWIERZAK
Keyword(s):  
Wittig Reaction ◽  
Secondary Amines ◽  
One Pot ◽  
One Pot Synthesis

One-pot synthesis of functionalized thioureas by reaction of benzoyl isothiocyanates, secondary amines, and alkyl propiolates

2008 ◽  
Vol 139 (9) ◽  
pp. 1025-1028 ◽  
Author(s):  
Issa Yavari ◽  
S. Zahra Sayyed-Alangi ◽  
Maryam Sabbaghan ◽  
Rahimeh Hajinasiri ◽  
Nasir Iravani
Keyword(s):  
Secondary Amines ◽  
One Pot ◽  
One Pot Synthesis ◽  
Benzoyl Isothiocyanates ◽  
Alkyl Propiolates

One-Pot Synthesis of 3-(1,2,3,4-Tetrahydroisoquinolin-1-yl)-isoquinolin-1(2H)-ones by Sequential DEAD-Promoted Oxidative Ugi/Wittig Reaction Starting from Phosphonium Salt Precursors

Synlett ◽  
2021 ◽  
Author(s):  
Long Zhao ◽  
Mao-Lin Yang ◽  
Mei Sun ◽  
Ming-Wu Ding
Keyword(s):  
Wittig Reaction ◽  
Phosphonium Salt ◽  
One Pot ◽  
One Pot Synthesis ◽  
Sequential Reactions

A new one-pot Synthesis of 3-(1,2,3,4-tetrahydroisoquinolin-1-yl)- isoquinolin-1(2H)-ones by DEAD-promoted oxidative Ugi/Wittig reaction was developed. The sequential reactions of (2-carboxybenzyl)triphenylphosphonium salts, isocyanides and N-aryl-1,2,3,4-tetrahydroisoquinolines produced 3-(1,2,3,4-tetrahydroisoquinolin-1-yl)- isoquinolin-1(2H)-ones in moderate to good overall yields in the presence of DEAD and Et3N.

One-pot synthesis of 3-aminofurans using a simple and efficient recyclable CuI/[bmim]PF6 system

2021 ◽  
Author(s):  
Guguloth Veeranna ◽  
Ramesh Balaboina ◽  
Narasimha Swamy Thirukovela ◽  
Ravindhar Vadde
Keyword(s):  
Secondary Amines ◽  
Terminal Alkynes ◽  
One Pot ◽  
One Pot Synthesis ◽  
System P ◽  
Three Component Reaction ◽  
The One

The one-pot three-component reaction of several 2-ketoaldehdyes, secondary amines and terminal alkynes to access 3-aminofurans was proceeded well in [bmim][PF6] using a simple and cheap CuI catalyst. The resulted 3-aminofuran...

One-Pot Synthesis of Symmetrical Tertiary and Secondary Amines from Carbonyl Compounds, Ammonium Carbonate and Carbon Monoxide as a Reductant

2019 ◽  
Vol 2019 (38) ◽  
pp. 6557-6560 ◽  
Author(s):  
Karim Muratov ◽  
Oleg I. Afanasyev ◽  
Ekaterina Kuchuk ◽  
Sofiya Runikhina ◽  
Denis Chusov
Keyword(s):  
Carbon Monoxide ◽  
Carbonyl Compounds ◽  
Ammonium Carbonate ◽  
Secondary Amines ◽  
One Pot ◽  
One Pot Synthesis

scholarly journals One-pot sequential synthesis of isocyanates and urea derivatives via a microwave-assisted Staudinger–aza-Wittig reaction

2013 ◽  
Vol 9 ◽  
pp. 2378-2386 ◽  
Author(s):  
Diego Carnaroglio ◽  
Katia Martina ◽  
Giovanni Palmisano ◽  
Andrea Penoni ◽  
Claudia Domini ◽  
...  
Keyword(s):  
Wittig Reaction ◽  
Scale Up ◽  
Alkyl Halides ◽  
Secondary Amines ◽  
Nucleophilic Substitutions ◽  
One Pot ◽  
Urea Derivatives ◽  
Step Process ◽  
Microwave Assisted ◽  
Simple Filtration

A fast and efficient protocol for the synthesis of N,N'-disubstituted urea derivatives from alkyl halides and primary or secondary amines has been developed. The synthetic pathway combines nucleophilic substitutions and a Staudinger–aza-Wittig reaction in the presence of polymer-bound diphenylphosphine under 14 bar of CO2 pressure and has been performed in a one-pot two-step process. The protocol has been optimized under microwave irradiation and the scale-up experiment has been conducted under conventional conditions in a Parr reactor. The final compounds were isolated after simple filtration in almost quantitative overall yields which makes this procedure facile and rapid to execute.

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