ChemInform Abstract: Rapid Reconstitution of Biosynthetic Machinery for Fungal Metabolites in Aspergillus oryzae: Total Biosynthesis of Aflatrem (I).

ChemInform ◽  
2015 ◽  
Vol 46 (11) ◽  
pp. no-no
Author(s):  
Koichi Tagami ◽  
Atsushi Minami ◽  
Ryuya Fujii ◽  
Chengwei Liu ◽  
Mizuki Tanaka ◽  
...  
Keyword(s):  
Aspergillus Oryzae ◽  
Fungal Metabolites ◽  
Biosynthetic Machinery

Total Biosynthesis of Antiangiogenic Agent (−)-Terpestacin by Artificial Reconstitution of the Biosynthetic Machinery in Aspergillus oryzae

2018 ◽  
Vol 83 (13) ◽  
pp. 7042-7048 ◽  
Author(s):  
Koji Narita ◽  
Atsushi Minami ◽  
Taro Ozaki ◽  
Chengwei Liu ◽  
Motoichiro Kodama ◽  
...  
Keyword(s):  
Aspergillus Oryzae ◽  
Antiangiogenic Agent ◽  
Biosynthetic Machinery

Rapid Reconstitution of Biosynthetic Machinery for Fungal Metabolites inAspergillus oryzae: Total Biosynthesis of Aflatrem

ChemBioChem ◽  
2014 ◽  
Vol 15 (14) ◽  
pp. 2076-2080 ◽  
Author(s):  
Koichi Tagami ◽  
Atsushi Minami ◽  
Ryuya Fujii ◽  
Chengwei Liu ◽  
Mizuki Tanaka ◽  
...  
Keyword(s):  
Fungal Metabolites ◽  
Biosynthetic Machinery

Calmodulin binding agents from selected fungal metabolites

Planta Medica ◽  
2014 ◽  
Vol 80 (10) ◽  
Author(s):  
P Del Valle ◽  
M González-Andrade ◽  
M Figueroa ◽  
R Mata
Keyword(s):  
Fungal Metabolites ◽  
Calmodulin Binding ◽  
Binding Agents

Prevalence of antimicrobial fungal metabolites in Hydrastis canadensis crude extracts

Planta Medica ◽  
2015 ◽  
Vol 81 (11) ◽  
Author(s):  
JM Egan ◽  
A Kaur ◽  
HA Raja ◽  
AR Brown ◽  
NH Oberlies ◽  
...  
Keyword(s):  
Fungal Metabolites ◽  
Hydrastis Canadensis ◽  
Crude Extracts

The Effects of Brinolase (Fibrinolytic Enzyme from Aspergillus Oryzae) on Platelet Aggregation of Dog and Man

1972 ◽  
Vol 28 (01) ◽  
pp. 031-048 ◽  
Author(s):  
W. H. E Roschlau ◽  
R Gage
Keyword(s):  
Platelet Aggregation ◽  
Aspergillus Oryzae ◽  
Degradation Products ◽  
Blood Platelet ◽  
Human Platelets ◽  
Fibrinolytic Enzyme ◽  
Inhibitory Effects ◽  
Blood Platelet Aggregation

SummaryInhibition of blood platelet aggregation by brinolase (fibrinolytic enzyme from Aspergillus oryzae) has been demonstrated with human platelets in vitro and with dog platelets in vivo and in vitro, using both ADP and collagen as aggregating stimuli. It is suggested that the optimal inhibitory effects of brinolase occur indirectly through the generation of plasma fibrinogen degradation products, without compromising platelet viability, rather than by direct proteolysis of platelet structures.

Gut Mycobiota and Fungal Metabolites in Human Homeostasis

2018 ◽  
Vol 20 (2) ◽  
pp. 232-240 ◽  
Author(s):  
Izabella Mogilnicka ◽  
Marcin Ufnal
Keyword(s):  
Wide Spectrum ◽  
Biological Effects ◽  
Fungal Species ◽  
Fungal Metabolites ◽  
Human Gut ◽  
Fecal Transplantation ◽  
Bacterial Microbiota ◽  
Bowel Diseases ◽  
Inflammatory Bowel

Background:Accumulating evidence suggests that microbiota play an important role in host’s homeostasis. Thus far, researchers have mostly focused on the role of bacterial microbiota. However, human gut is a habitat for several fungal species, which produce numerous metabolites. Furthermore, various types of food and beverages are rich in a wide spectrum of fungi and their metabolites.Methods:We searched PUBMED and Google Scholar databases to identify clinical and pre-clinical studies on fungal metabolites, composition of human mycobiota and fungal dysbiosis.Results:Fungal metabolites may serve as signaling molecules and exert significant biological effects including trophic, anti-inflammatory or antibacterial actions. Finally, research suggests an association between shifts in gut fungi composition and human health. Changes in mycobiota composition have been found in obesity, hepatitis and inflammatory bowel diseases.Conclusion:The influence of mycobiota and dietary fungi on homeostasis in mammals suggests a pharmacotherapeutic potential of modulating the mycobiota which may include treatment with probiotics and fecal transplantation. Furthermore, antibacterial action of fungi-derived molecules may be considered as a substitution for currently used antibacterial agents and preservatives in food industry.

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