scholarly journals The G protein‐coupled receptor 15 (GPR15) regulates cutaneous immunology by maintaining dendritic epidermal T cells and regulating the skin microbiome

2021 ◽  
Author(s):  
Tanya Sezin ◽  
Lina Jegodzinski ◽  
Lisa‐Maria Meyne ◽  
Yask Gupta ◽  
Sadegh Mousavi ◽  
...  
Keyword(s):  
T Cells ◽  
G Protein ◽  
Skin Microbiome ◽  
G Protein Coupled Receptor ◽  
Dendritic Epidermal T Cells ◽  
G Protein Coupled

scholarly journals Expression of the G-protein--coupled receptor BLR1 defines mature, recirculating B cells and a subset of T-helper memory cells

Blood ◽  
1994 ◽  
Vol 84 (3) ◽  
pp. 830-840 ◽  
Author(s):  
R Forster ◽  
T Emrich ◽  
E Kremmer ◽  
M Lipp
Keyword(s):  
T Cells ◽  
B Cells ◽  
Cord Blood ◽  
G Protein ◽  
Blood Cells ◽  
Memory Cells ◽  
T Helper ◽  
G Protein Coupled Receptor ◽  
Color Flow ◽  
G Protein Coupled

Abstract The G-protein-coupled receptor BLR1 related to receptors for chemokines and neuropeptides has been identified as the first lymphocyte-specific member of the gene family characterized by seven transmembrane-spanning regions. Using a high-affinity anti-BLR1 monoclonal antibody (MoAb) and three-color flow cytometry it is shown that BLR1 expression on peripheral blood cells is limited to B cells and to a subset of CD4+ (14%) and CD8+ (2%) lymphocytes. T cells expressing BLR1 were positive for CD45R0, were negative for interleukin-2 receptors, show high levels of CD44, and show low levels of L-selectin. The majority of CD4+ cells originating from secondary lymphatic tissue, but none of cord blood- derived T cells, express BLR1. These observations suggest that BLR1 is a marker for memory T cells. Furthermore, BLR1 expression was detected on all CD19+ peripheral or tonsillar B lymphocytes, but only on a fraction of cord blood cells and bone marrow cells expressing CD19, sIgM, or sIgD. Interestingly, activation of both mature B and T cells by CD40 MoAb and CD3 MoAb, respectively, led to complete downregulation of BLR1. These data suggest that the G-protein-coupled receptor BLR1 is involved in functional control of mature recirculating B cells and T- helper memory cells participating in cell migration and cell activation.

scholarly journals A T-cell–redirecting bispecific G-protein–coupled receptor class 5 member D x CD3 antibody to treat multiple myeloma

Blood ◽  
2020 ◽  
Vol 135 (15) ◽  
pp. 1232-1243 ◽  
Author(s):  
Kodandaram Pillarisetti ◽  
Suzanne Edavettal ◽  
Mark Mendonça ◽  
Yingzhe Li ◽  
Mark Tornetta ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
T Cells ◽  
T Cell ◽  
G Protein ◽  
T Cell Activation ◽  
Cell Activation ◽  
Plasma Cells ◽  
Phase 1 ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

Abstract T-cell–mediated approaches have shown promise in myeloma treatment. However, there are currently a limited number of specific myeloma antigens that can be targeted, and multiple myeloma (MM) remains an incurable disease. G-protein–coupled receptor class 5 member D (GPRC5D) is expressed in MM and smoldering MM patient plasma cells. Here, we demonstrate that GPRC5D protein is present on the surface of MM cells and describe JNJ-64407564, a GPRC5DxCD3 bispecific antibody that recruits CD3+ T cells to GPRC5D+ MM cells and induces killing of GPRC5D+ cells. In vitro, JNJ-64407564 induced specific cytotoxicity of GPRC5D+ cells with concomitant T-cell activation and also killed plasma cells in MM patient samples ex vivo. JNJ-64407564 can recruit T cells and induce tumor regression in GPRC5D+ MM murine models, which coincide with T-cell infiltration at the tumor site. This antibody is also able to induce cytotoxicity of patient primary MM cells from bone marrow, which is the natural site of this disease. GPRC5D is a promising surface antigen for MM immunotherapy, and JNJ-64407564 is currently being evaluated in a phase 1 clinical trial in patients with relapsed or refractory MM (NCT03399799).

G Protein Coupled Receptor Kinase 3 (GRK3) - Deficient T Cells Demonstrate Enhanced Migration To CXCL12 And CX3CL1

2011 ◽  
Vol 127 (2) ◽  
pp. AB166-AB166
Author(s):  
L.R. Rothlein ◽  
R.G. Timoshchenko ◽  
D.J. Fitzhugh ◽  
M.W. McGinnis ◽  
G. Laroche ◽  
...  
Keyword(s):  
T Cells ◽  
G Protein ◽  
Receptor Kinase ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

scholarly journals G Protein-Coupled Receptor 83 Overexpression in Naive CD4+CD25− T Cells Leads to the Induction of Foxp3+ Regulatory T Cells In Vivo

2006 ◽  
Vol 177 (1) ◽  
pp. 209-215 ◽  
Author(s):  
Wiebke Hansen ◽  
Karin Loser ◽  
Astrid M. Westendorf ◽  
Dunja Bruder ◽  
Susanne Pfoertner ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
G Protein ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

scholarly journals Identification of a Gene Induced by Glucocorticoids in Murine T-Cells: A Potential G Protein-Coupled Receptor

1991 ◽  
Vol 5 (9) ◽  
pp. 1331-1338 ◽  
Author(s):  
Maureen T. Harrigan ◽  
N. Faith Campbell ◽  
Suzanne Bourgeois
Keyword(s):  
T Cells ◽  
G Protein ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

scholarly journals Toll-Like Receptor 3 Signalling Up-Regulates Expression of the HIV Co-Receptor G-Protein Coupled Receptor 15 on Human CD4+ T Cells

PLoS ONE ◽  
2014 ◽  
Vol 9 (2) ◽  
pp. e88195 ◽  
Author(s):  
Miriam Kiene ◽  
Bence Rethi ◽  
Marianne Jansson ◽  
Stephanie Dillon ◽  
Eric Lee ◽  
...  
Keyword(s):  
T Cells ◽  
G Protein ◽  
Cd4 T Cells ◽  
Toll Like Receptor ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

scholarly journals Expression of the G-protein--coupled receptor BLR1 defines mature, recirculating B cells and a subset of T-helper memory cells

Blood ◽  
1994 ◽  
Vol 84 (3) ◽  
pp. 830-840 ◽  
Author(s):  
R Forster ◽  
T Emrich ◽  
E Kremmer ◽  
M Lipp
Keyword(s):  
T Cells ◽  
B Cells ◽  
Cord Blood ◽  
G Protein ◽  
Blood Cells ◽  
Memory Cells ◽  
T Helper ◽  
G Protein Coupled Receptor ◽  
Color Flow ◽  
G Protein Coupled

The G-protein-coupled receptor BLR1 related to receptors for chemokines and neuropeptides has been identified as the first lymphocyte-specific member of the gene family characterized by seven transmembrane-spanning regions. Using a high-affinity anti-BLR1 monoclonal antibody (MoAb) and three-color flow cytometry it is shown that BLR1 expression on peripheral blood cells is limited to B cells and to a subset of CD4+ (14%) and CD8+ (2%) lymphocytes. T cells expressing BLR1 were positive for CD45R0, were negative for interleukin-2 receptors, show high levels of CD44, and show low levels of L-selectin. The majority of CD4+ cells originating from secondary lymphatic tissue, but none of cord blood- derived T cells, express BLR1. These observations suggest that BLR1 is a marker for memory T cells. Furthermore, BLR1 expression was detected on all CD19+ peripheral or tonsillar B lymphocytes, but only on a fraction of cord blood cells and bone marrow cells expressing CD19, sIgM, or sIgD. Interestingly, activation of both mature B and T cells by CD40 MoAb and CD3 MoAb, respectively, led to complete downregulation of BLR1. These data suggest that the G-protein-coupled receptor BLR1 is involved in functional control of mature recirculating B cells and T- helper memory cells participating in cell migration and cell activation.

Expression of the G-protein coupled receptor EBI2 in T cells is highly regulated and confers pathogenicity to myelin specific Th17 cells

2014 ◽  
Vol 275 (1-2) ◽  
pp. 211 ◽  
Author(s):  
Florian Wanke ◽  
Andrew L. Croxford ◽  
André P. Heinen ◽  
Stephanie Firmenich ◽  
Sonja Moos ◽  
...  
Keyword(s):  
T Cells ◽  
G Protein ◽  
Th17 Cells ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled
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