scholarly journals Self‐assembly of Cholesterol‐Doxorubicin and TPGS into Prodrug‐based Nanoparticles with Enhanced Cellular Uptake and Lysosome‐dependent Pathway in Breast Cancer Cells

2021 ◽  
pp. 2000337
Author(s):  
Filipe Olim ◽  
Ana Rute Neves ◽  
Mariana Vieira ◽  
Helena Tomás ◽  
Ruilong Sheng
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Cellular Uptake ◽  
Self Assembly ◽  
Breast Cancer Cells ◽  
Dependent Pathway

scholarly journals Super Magnetic Niosomal Nanocarrier as a New Approach for Treatment of Breast Cancer: A Case Study on SK-BR-3 and MDA-MB-231 Cell Lines

2021 ◽  
Vol 22 (15) ◽  
pp. 7948
Author(s):  
Elham Jamshidifar ◽  
Faten Eshrati Yeganeh ◽  
Mona Shayan ◽  
Mohammad Tavakkoli Yaraki ◽  
Mahsa Bourbour ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Cell Lines ◽  
Cancer Cell ◽  
Cellular Uptake ◽  
Targeted Delivery ◽  
Breast Cancer Cells ◽  
Cancer Cell Lines ◽  
Breast Cancer Cell Lines ◽  
Silica Layer

In the present study, a magnetic niosomal nanocarrier for co-delivery of curcumin and letrozole into breast cancer cells has been designed. The magnetic NiCoFe2O4 core was coated by a thin layer of silica, followed by a niosomal structure, allowing us to load letrozole and curcumin into the silica layer and niosomal layer, respectively, and investigate their synergic effects on breast cancer cells. Furthermore, the nanocarriers demonstrated a pH-dependent release due to the niosomal structure at their outer layer, which is a promising behavior for cancer treatment. Additionally, cellular assays revealed that the nanocarriers had low cellular uptake in the case of non-tumorigenic cells (i.e., MCF-10A) and related high viability but high cellular uptake in cancer cell lines (i.e., MDA-MB-231 and SK-BR-3) and related low viability, which is evidenced in their high cytotoxicity against different breast cancer cell lines. The cytotoxicity of the letrozole/curcumin co-loaded nanocarrier is higher than that of the aqueous solutions of both drugs, indicating their enhanced cellular uptake in their encapsulated states. In particular, NiCoFe2O4@L-Silica-L@C-Niosome showed the highest cytotoxicity effects on MDA-MB-231 and SK-BR-3 breast cancer cells. The observed cytotoxicity was due to regulation of the expression levels of the studied genes in breast cancer cells, where downregulation was observed for the Bcl-2, MMP 2, MMP 9, cyclin D, and cyclin E genes while upregulation of the expression of the Bax, caspase-3, and caspase-9 genes was observed. The flow cytometry results also revealed that NiCoFe2O4@L-Silica-L@C-Niosome enhanced the apoptosis rate in both MDA-MB-231 and SK-BR-3 cells compared to the control samples. The findings of our research show the potential of designing magnetic niosomal formulations for simultaneous targeted delivery of both hydrophobic and hydrophilic drugs into cancer cells in order to enhance their synergic chemotherapeutic effects. These results could open new avenues into the future of nanomedicine and the development of theranostic agents.

scholarly journals Mechanism of cellular uptake and cytotoxicity of paclitaxel loaded lipid nanocapsules in breast cancer cells

2021 ◽  
Vol 597 ◽  
pp. 120217
Author(s):  
Remya Valsalakumari ◽  
Sunil Kumar Yadava ◽  
Marzena Szwed ◽  
Abhilash D. Pandya ◽  
Gunhild Mari Mælandsmo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Cellular Uptake ◽  
Breast Cancer Cells ◽  
Lipid Nanocapsules

scholarly journals Elaborating the Mechanism of Cell Killing of a Novel Chemotheraputic Drug Targeting Breast Cancer

2019 ◽  
Vol 4 ◽  
Author(s):  
Phat Do
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Unique Feature ◽  
Cell Killing ◽  
Tamoxifen Treatment ◽  
Length Variation ◽  
Er Positive ◽  
New Diagnosis ◽  
Dependent Pathway

Breast cancer (BC) is the second most commonly diagnosed cancer in women in the world. In 2018, there were more than 2 million new diagnosis. It is estimated that1 in 8 women will develop invasive breast cancer over the course of her lifetime. Traditional treatments of BC include surgery, radiation, and chemotherapy therapy; however, these treatments are non-specific and potentially kill peripheral, healthy cells. More specific treatments are needed, most notably to target a unique feature of the cancer cells. Interestingly, 70% of BC cells upregulate estradiol-dependent pathway, a characteristic essential for rapid cell growth. Current BC drugs, such as Tamoxifen, Faslodex, or Femarahave targeted this pathway to preferentially kill BC cells. However, the problems with these drugs are two-fold. (1) Drugs produce considerable side effects. For example, Femera causes considerable musculoskeletal failures. Tamoxifen is also shown to produce secondary cancer growth, such as endometrial cancer. (2) Breast cancer cells resist drugs very quickly. For instance, one third of women who are treated with Tamoxifen for five years relapse within fifteen years. The resulting tumor then become resistant to Tamoxifen treatment. For these two reasons, there is a need for new chemotherapeutic drugs. Our research group studies a novel estrogen-receptor targeting drug: Estradiol-R-Melex. This compound has the estradiol molecule linked to a DNA alkylating agent, Melex. We connected the two moieties using a linker consisting of various lengths, i.e., one, two, and three methyl groups. The linker length variation is to optimize the cell killing property of our small drug molecule. We hypothesize that Est-n-Melex enters the ER positive cancer cells more rapidly than ER-normal cells.

scholarly journals Drug-Triggered Self-Assembly of Linear Polymer into Nanoparticles for Simultaneous Delivery of Hydrophobic and Hydrophilic Drugs in Breast Cancer Cells

ACS Omega ◽  
2017 ◽  
Vol 2 (12) ◽  
pp. 8730-8740 ◽  
Author(s):  
Sandeep Palvai ◽  
Libi Anandi ◽  
Sujit Sarkar ◽  
Meera Augustus ◽  
Sudip Roy ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Self Assembly ◽  
Breast Cancer Cells ◽  
Linear Polymer ◽  
Hydrophilic Drugs ◽  
Simultaneous Delivery

l-Cysteine/AgNO2 low molecular weight gelators: self-assembly and suppression of MCF-7 breast cancer cells

Soft Matter ◽  
2020 ◽  
Vol 16 (42) ◽  
pp. 9669-9673
Author(s):  
Dmitry V. Vishnevetskii ◽  
Arif R. Mekhtiev ◽  
Tatyana V. Perevozova ◽  
Dmitry V. Averkin ◽  
Alexandra I. Ivanova ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Molecular Weight ◽  
Cancer Cells ◽  
Self Assembly ◽  
Breast Cancer Cells ◽  
Low Molecular Weight ◽  
Human Breast ◽  
Selective Toxicity ◽  
Low Molecular Weight Gelators ◽  
Mcf 7

We present a method for the preparation of a new hydrogel based on low molecular weight gelators that exhibits selective toxicity towards MCF-7 human breast cancer cells.

Linoleic acid induces migration and invasion through FFAR4- and PI3K-/Akt-dependent pathway in MDA-MB-231 breast cancer cells

2017 ◽  
Vol 34 (6) ◽  
Author(s):  
Nathalia Serna-Marquez ◽  
Ricardo Diaz-Aragon ◽  
Emmanuel Reyes-Uribe ◽  
Pedro Cortes-Reynosa ◽  
Eduardo Perez Salazar
Keyword(s):  
Breast Cancer ◽  
Linoleic Acid ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Migration And Invasion ◽  
Dependent Pathway

Supramolecular assembly of fluorogenic glyco-dots from perylenediimide-based glycoclusters for targeted imaging of cancer cells

2017 ◽  
Vol 53 (87) ◽  
pp. 11937-11940 ◽  
Author(s):  
Ying Liu ◽  
Ding-Kun Ji ◽  
Lei Dong ◽  
Nicolas Galanos ◽  
Yi Zang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Triple Negative Breast Cancer ◽  
Self Assembly ◽  
Breast Cancer Cells ◽  
Triple Negative ◽  
Supramolecular Assembly ◽  
Targeted Imaging

Supramolecular self-assembly between perylenediimide-based glycoclusters and a red-emitting fluorophore produces structurally uniform and stable glyco-dots amenable to targeted fluorogenic imaging of liver and triple-negative breast cancer cells.

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