Diagnostic accuracy of clathrin heavy chain staining in a marker panel for the diagnosis of small hepatocellular carcinoma

Clathrin forms the polyhedral cage of coated vesicles, which mediate the transfer of selected membrane components within eukaryotic cells. Clathrin cages and coated vesicles have been extensively studied by electron microscopy of negatively stained preparations and shadowed specimens. From these studies the gross morphology of the outer part of the polyhedral coat has been established and some features of the packing of clathrin trimers into the coat have also been described. However these previous studies have not revealed any internal details about the position of the terminal domain of the clathrin heavy chain, the location of the 100kd-50kd accessory coat proteins or the interactions of the coat with the enclosed membrane.

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Serum and tissue PIVKA-II expression reflect the biological malignant potential of small hepatocellular carcinoma

Gastroenterology ◽

10.1016/s0016-5085(01)82773-6 ◽

2001 ◽

Vol 120 (5) ◽

pp. A558-A558

Author(s):

M TAMANO ◽

K KOJIMA ◽

M OGUMA ◽

M LIJIMA ◽

T MUROHISA ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Malignant Potential ◽

Small Hepatocellular Carcinoma

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Early and non-invasive diagnosis of small hepatocellular carcinoma using real-time elastography

Ultraschall in der Medizin - European Journal of Ultrasound ◽

10.1055/s-2008-1079787 ◽

2008 ◽

Vol 29 (S 1) ◽

Author(s):

L Gheorghe ◽

S Iacob ◽

I Lupescu ◽

G Becheanu ◽

M Dumbrava ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Real Time ◽

Small Hepatocellular Carcinoma ◽

Non Invasive

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Transcatheter Chemoembolization of a Hepatocellular Carcinoma Utilizing Lipiodol through the Pancreaticoduodenal Arcade: A Case Report

American Journal of Interventional Radiology ◽

10.25259/ajir-19-2018 ◽

2018 ◽

Vol 2 ◽

pp. 5

Author(s):

Scott P Patterson ◽

Richard G Foster

Keyword(s):

Hepatocellular Carcinoma ◽

Case Report ◽

Vascular Anatomy ◽

Left Gastric Artery ◽

Target Lesion ◽

Celiac Artery ◽

Small Hepatocellular Carcinoma ◽

Gastric Artery ◽

Variant Anatomy ◽

Pancreaticoduodenal Arcade

This case report describes the chemoembolization of a small hepatocellular carcinoma employing a lipiodol drug delivery system utilizing a novel arterial pathway. Because the target lesion was precariously located adjacent to the inferior heart border and the diaphragm, it was unsuitable for imaging-guided microwave ablation. To achieve chemoembolization, several intraprocedural adaptations were necessary, given the variant anatomy encountered and difficulty accessing the left gastric artery through a celiac artery approach. The left gastric artery was selected from a superior mesenteric artery approach through the pancreaticoduodenal arcade (Rio Branco’s arcade). This case illustrates the importance of a mastery of the vascular anatomy and variants of hepatic arterial flow.

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Is postoperative adjuvant transchatheter arterial chemoembolization necessary for small hepatocellular carcinoma patients: a randomized controlled trial

Academic Journal of Second Military Medical University ◽

10.3724/sp.j.1008.2012.00274 ◽

2012 ◽

Vol 32 (3) ◽

pp. 274-279 ◽

Cited By ~ 4

Author(s):

Feng XU ◽

Yang-qing HUANG ◽

Ye-sheng LI ◽

Lu WU ◽

Jia-mei YANG

Keyword(s):

Hepatocellular Carcinoma ◽

Randomized Controlled Trial ◽

Controlled Trial ◽

Small Hepatocellular Carcinoma ◽

Randomized Controlled ◽

Arterial Chemoembolization

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Differentiation between hepatocellular carcinoma and intrahepatic cholangiocarcinoma using contrast-enhanced ultrasound: A systematic review and meta-analysis

Clinical Hemorheology and Microcirculation ◽

10.3233/ch-211145 ◽

2021 ◽

pp. 1-17

Author(s):

Yanling Chen ◽

Wenping Wang

Keyword(s):

Hepatocellular Carcinoma ◽

Diagnostic Accuracy ◽

Publication Bias ◽

Likelihood Ratio ◽

Intrahepatic Cholangiocarcinoma ◽

Cochrane Library ◽

Arterial Phase ◽

Contrast Enhanced Ultrasound ◽

Diagnostic Ability ◽

Contrast Enhanced

AIM: To explore the diagnostic ability of contrast-enhanced ultrasound (CEUS) in distinguishing intrahepatic cholangiocarcinoma (ICC) from hepatocellular carcinoma (HCC). MATERIALS AND METHODS: PubMed, EMBASE, Cochrane Library, and Web of Science were systematically searched for studies reporting the diagnostic accuracy of CEUS in differentiating ICC from HCC. The diagnostic ability of CEUS was assessed based on the pooled sensitivity, specificity, diagnostic odds ratio (DOR), positive likelihood ratio (PLR), negative likelihood ratio (NLR) and area under the curve (AUC) with 95% confidence intervals (CIs). The methodologic quality was assessed by the QUADAS-2 tool. Subgroup analyses, meta-regression and investigation of publication bias were performed to identify the source of heterogeneity. RESULTS: A total of eight studies were included, consisting of 1,116 patients with HCC and 529 with ICC. The general diagnostic performance of CEUS in distinguishing ICC and HCC were as follows: pooled sensitivity, 0.92 (95% CI: 0.84–0.96); pooled specificity, 0.87 (95% CI: 0.79–0.92); pooled PLR, 7.1 (95% CI: 4.1–12.0); pooled NLR, 0.09 (95% CI: 0.05–0.19); pooled DOR, 76 (95% CI: 26–220) and AUC, 0.95(95% CI: 0.93–0.97). Different liver background may be a potential factor that influenced the diagnostic accuracy of CEUS according to the subgroup analysis, with the pooled DOR of 89.67 in the mixed liver background group and 46.87 in the cirrhosis group, respectively. Six informative CEUS features that may help differentiate HCC from ICC were extracted. The three CEUS features favoring HCC were arterial phase hyperenhancement(APHE), mild washout and late washout (>60s); the three CEUS favoring ICC were arterial rim enhancement, marked washout and early washout(<60s). No potential publication bias was observed. CONCLUSION: CEUS showed great diagnostic ability in differentiating ICC from HCC, which may be promising for noninvasive evaluation of these diseases.

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