Use of vitamin K antagonists and risk of prostate cancer: Meta–analysis and nationwide case–control study

2018 ◽  
Vol 144 (7) ◽  
pp. 1522-1529 ◽  
Author(s):  
Kasper Bruun Kristensen ◽  
Patricia Hjorslev Jensen ◽  
Charlotte Skriver ◽  
Søren Friis ◽  
Anton Pottegård
Keyword(s):  
Prostate Cancer ◽  
Vitamin K ◽  
Case Control Study ◽  
Meta Analysis ◽  
Vitamin K Antagonists ◽  
Case Control ◽  
Control Study

scholarly journals The association of POLR2E rs3787016 polymorphism and cancer risk: a Chinese case–control study and meta-analysis

2018 ◽  
Vol 38 (6) ◽  
Author(s):  
Bifeng Chen ◽  
Shang Wang ◽  
Guangxin Ma ◽  
Jin Han ◽  
Jingli Zhang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Lung Cancer ◽  
Liver Cancer ◽  
Cancer Risk ◽  
Cancer Patients ◽  
Case Control Study ◽  
Meta Analysis ◽  
Case Control ◽  
A Genome ◽  
Control Study

How single nucleotide polymorphisms in long non-coding RNAs are involved in cancer susceptibility remains poorly understood. We hypothesized that polymerase II polypeptide E (POLR2E) rs3787016 polymorphism, identified in a genome-wide association study of prostate cancer, might be a common genetic risk factor for cancer risk. To address this issue, we here conducted a case–control study to investigate the association of POLR2E rs3787016 polymorphism with risk of liver and lung cancer (including 800 normal controls, 480 liver cancer patients, and 550 lung cancer patients), followed by a meta-analysis. The genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism and confirmed by sequencing. Although no significant association was found for rs3787016 with risk of liver or lung cancer, the further stratified analysis identified that rs3787016 contributed to liver cancer risk particularly for over than 60 years individuals who drink. Moreover, the meta-analysis demonstrated that rs3787016 was associated with overall cancer risk and prostate cancer risk. Collectively, the POLR2E rs3787016 polymorphism may be a valuable biomarker for cancer predisposition.

scholarly journals p27-V109G Polymorphism Is Not Associated with the Risk of Prostate Cancer: A Case-Control Study of Han Chinese Men in Central China

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Meng Zhang ◽  
Qianjun Liang ◽  
Ligang Zhang ◽  
Zongyao Hao ◽  
Jun Zhou ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Risk ◽  
Case Control Study ◽  
Meta Analysis ◽  
Case Control ◽  
Han Chinese ◽  
Central China ◽  
Evidence Based ◽  
Cancer Type ◽  
Control Study

Objective. We conducted an update meta-analysis aiming to verify the association between p27-V109G polymorphism and cancer risk, particular for prostate cancer (PCa). Then, we conducted a case-control study of Han Chinese in central China to verify the evidence-based results. Methods. Relevant studies were collected from diverse databases up to March 2017. In addition, a hospital-based (H-B) case-control study enrolling 90 PCa patients and 140 healthy controls was included to verify these evidence-based findings. Genetic risk was calculated by odds ratio (OR) with its corresponding 95% confidence interval (CI). The p27-V109G polymorphism was determined by MassARRAY genotyping method. Results. Finally, twenty-four published studies comprising 9627 cases and 12,102 controls were enrolled for the current meta-analysis. Overall analysis suggested that p27-V109G polymorphism decreased overall cancer risk in allelic contrast, heterozygote, and dominant models. When stratified analysis was conducted by ethnicity, data revealed that p27-V109G polymorphism was associated with a decreased cancer risk in Caucasians. Highlighted in the subgroup analysis by cancer type, we uncovered a significantly decreased risk of PCa in allelic contrast, dominant, homogeneous, and recessive models. However, in the validation case-control study, we failed to uncover a positive association between p27-V109G polymorphism and PCa risk. In addition, negative results were also identified when subgroup analyses were stratified by age, tumor grade, tumor stage, PSA levels, and other measurements. Conclusion. Although evidence-based results suggest that p27-V109G polymorphism plays a protective role in overall cancer risk, particularly for PCa, our case-control study failed to validate any association between this particular polymorphism and PCa risk.

scholarly journals Urinary estrogen metabolites and prostate cancer: a case-control study and meta-analysis

2009 ◽  
Vol 28 (1) ◽  
pp. 135 ◽  
Author(s):  
Maddalena Barba ◽  
Li Yang ◽  
Holger J Schünemann ◽  
Francesca Sperati ◽  
Sara Grioni ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Case Control Study ◽  
Meta Analysis ◽  
Case Control ◽  
Estrogen Metabolites ◽  
Control Study

scholarly journals Height and Prostate Cancer Risk: A Large Nested Case-Control Study (ProtecT) and Meta-analysis

2008 ◽  
Vol 17 (9) ◽  
pp. 2325-2336 ◽  
Author(s):  
Luisa Zuccolo ◽  
Ross Harris ◽  
David Gunnell ◽  
Steven Oliver ◽  
Jane Athene Lane ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Risk ◽  
Case Control Study ◽  
Meta Analysis ◽  
Prostate Cancer Risk ◽  
Case Control ◽  
Nested Case Control ◽  
Control Study
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