Development of biodegradable poly(propylene fumarate)/poly(lactic-co-glycolic acid) blend microspheres. II. Controlled drug release and microsphere degradation

2004 ◽  
Vol 70A (2) ◽  
pp. 293-302 ◽  
Author(s):  
Diederik H. R. Kempen ◽  
Lichun Lu ◽  
Xun Zhu ◽  
Choll Kim ◽  
Esmaiel Jabbari ◽  
...  
Keyword(s):  
Drug Release ◽  
Glycolic Acid ◽  
Controlled Drug Release ◽  
Biodegradable Poly ◽  
Poly Propylene

scholarly journals New Biodegradable Poly(l-lactide)-Block-Poly(propylene adipate) Copolymer Microparticles for Long-Acting Injectables of Naltrexone Drug

Polymers ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 852 ◽  
Author(s):  
Stavroula Nanaki ◽  
Athina Viziridou ◽  
Alexandra Zamboulis ◽  
Margaritis Kostoglou ◽  
Georgios Z. Papageorgiou ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Drug Release ◽  
Amorphous State ◽  
Copolymer Composition ◽  
Polymeric Matrices ◽  
Release Studies ◽  
Biodegradable Poly ◽  
Long Acting ◽  
Poly Propylene ◽  
Tga And Dsc

In the present study, novel block copolymers of poly(l-lactide)-block-poly(propylene adipate) (PLLA-b-PPAd) were synthesized in two ratios, 90/10 and 75/25 w/w and were further investigated as long-acting injectable (LAI) polymeric matrices in naltrexone base microparticle formulations. The synthesized polymers were characterized by 1H-NMR, 13C-NMR, FTIR, XRD, TGA and DSC. NMR and FTIR spectroscopies confirmed the successful synthesis of copolymers while DSC showed that these are block copolymers with well-defined and separated blocks. Microparticles were prepared by single emulsification method and were further characterized. Nanoparticles in the range of 0.4–4.5 μm were prepared as indicated by SEM, with copolymers giving the lowest particle size. By XRD and DSC it was found that naltrexone was present in the amorphous state in its microparticles. Dissolution study showed a drug release extending over seven days, indicating that these novel PLLA-b-PPAd copolymers could be promising matrices for naltrexone’s LAI formulations. It was evidenced that drug release depended on the copolymer composition. Model release studies showed that drug release is controlled by diffusion.

Development of biodegradable poly(propylene fumarate)/poly(lactic-co-glycolic acid) blend microspheres. I. Preparation and characterization

2004 ◽  
Vol 70A (2) ◽  
pp. 283-292 ◽  
Author(s):  
Diederik H. R. Kempen ◽  
Lichun Lu ◽  
Xun Zhu ◽  
Choll Kim ◽  
Esmaiel Jabbari ◽  
...  
Keyword(s):  
Glycolic Acid ◽  
Biodegradable Poly ◽  
Poly Propylene

scholarly journals Synthesis and characterization of biodegradable poly(ether-ester) urethane acrylates for controlled drug release

2017 ◽  
Vol 74 ◽  
pp. 270-278 ◽  
Author(s):  
Xuepeng Feng ◽  
Guirong Wang ◽  
Kevin Neumann ◽  
Wei Yao ◽  
Lin Ding ◽  
...  
Keyword(s):  
Drug Release ◽  
Controlled Drug Release ◽  
Synthesis And Characterization ◽  
Biodegradable Poly ◽  
Ether Ester

Controlled drug release from a novel injectable biodegradable microsphere/scaffold composite based on poly(propylene fumarate)

2006 ◽  
Vol 77A (1) ◽  
pp. 103-111 ◽  
Author(s):  
Diederik H. R. Kempen ◽  
Lichun Lu ◽  
Choll Kim ◽  
Xun Zhu ◽  
Wouter J. A. Dhert ◽  
...  
Keyword(s):  
Drug Release ◽  
Controlled Drug Release ◽  
Poly Propylene

Microspheres of new alternating copolyesters derived from glycolic acid units for controlled drug release

2008 ◽  
Vol 110 (4) ◽  
pp. 2127-2138 ◽  
Author(s):  
Meritxell Martínez-Palau ◽  
Lourdes Franco ◽  
Jordi Puiggalí
Keyword(s):  
Drug Release ◽  
Glycolic Acid ◽  
Controlled Drug Release
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