Review for "Test-retest reliability and correlates of vertebral bone marrow lipid composition by lipidomics among children with varying degrees of bone fragility"

2020 ◽  
Author(s):  
ALBERTO FALCHETTI
Keyword(s):  
Bone Marrow ◽  
Lipid Composition ◽  
Bone Fragility ◽  
Retest Reliability ◽  
Vertebral Bone ◽  
Vertebral Bone Marrow ◽  
Test Retest Reliability

scholarly journals Test–Retest Reliability and Correlates of Vertebral Bone Marrow Lipid Composition by Lipidomics Among Children With Varying Degrees of Bone Fragility

JBMR Plus ◽  
2020 ◽  
Vol 4 (10) ◽  
Author(s):  
Daniel G Whitney ◽  
Maureen J Devlin ◽  
Andrea I Alford ◽  
Christopher M Modlesky ◽  
Mark D Peterson ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Lipid Composition ◽  
Bone Fragility ◽  
Retest Reliability ◽  
Vertebral Bone ◽  
Vertebral Bone Marrow ◽  
Test Retest Reliability

scholarly journals Vertebral Bone Marrow and Endplate Assessment on MR Imaging for the Differentiation of Modic Type 1 Endplate Changes and Infectious Spondylodiscitis

2020 ◽  
Vol 9 (3) ◽  
pp. 826 ◽  
Author(s):  
Ursula Schwarz-Nemec ◽  
Klaus M. Friedrich ◽  
Christoph Stihsen ◽  
Felix K. Schwarz ◽  
Siegfried Trattnig ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Mr Imaging ◽  
Diagnostic Accuracy ◽  
Characteristic Analysis ◽  
Vertebral Bone ◽  
Endplate Changes ◽  
Modic Type ◽  
Infectious Spondylodiscitis ◽  
Vertebral Bone Marrow

On magnetic resonance (MR) imaging, Modic type 1 (MT1) endplate changes and infectious spondylodiscitis share similar findings. Therefore, this study investigated vertebral bone marrow and endplate changes to enable their differentiation. The lumbar spine MR examinations of 91 adult patients were retrospectively included: 39 with MT1; 19 with early spondylodiscitis without abscess; and 33 with advanced spondylodiscitis with abscess. The assessment included percentage of bone marrow edema on sagittal short tau inversion recovery images, and the signal ratio of edema to unaffected bone and endplate contour (normal; irregular, yet intact; blurred; destructive) on sagittal unenhanced T1-weighted images. Differences were tested for statistical significance by Chi-square test and mixed model analysis of variance. The MR diagnostic accuracy in differentiating MT1 and spondylodiscitis was assessed by cross-tabulation and receiver-operating characteristic analysis. The endplate contours, edema extents, and T1-signal ratios of MT1 (extent, 31.96%; ratio, 0.83) were significantly different (p < 0.001) from early spondylodiscitis (56.42%; 0.60), and advanced spondylodiscitis (91.84%; 0.61). The highest diagnostic accuracy (sensitivity, 94.87%; specificity, 94.23%; accuracy, 94.51%) in identifying MT1 was provided by an irregular, yet intact endplate contour. This may be a useful MR feature for the differentiation between MT1 and spondylodiscitis, particularly in its early stage.

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