Effects of a combined estrogen-gestagen regimen on serum levels of the carboxy-terminal propeptide of human type I procollagen in osteoporosis

Minisola S, Romagnoli E, Scarnecchia L, Rosso R, Pacitti MT, Scarda A, Mazzuoli G. Serum carboxyterminal propeptide of human type I procollagen in patients with primary hyperparathyroidism: studies in basal conditions and after parathyroid surgery. Eur I Endocrinol 1994;130:587–91. ISSN 0804-4643 This study was carried out in order to evaluate serum carboxy-terminal propeptide of human type I procollagen (PICP) in patients with primary hyperparathyroidism and to examine its changes following parathyroidectomy. Seventeen patients (four males and 13 famels, aged 53.8 ± 3.1 sem years) were studied in basal conditions; six patients also were investigated after successful parathyroid surgery. Mean serum PICP values of patients with primary hyperparathyroidism (194.5 ± 27 sem μg/l) were significantly higher (p < 0.001) with respect to those found in normal subjects. However, deviations from the norm (Z score values) were significantly less with respect to deviations of serum osteocalcin, alkaline phosphatase and urinary hydroxyproline/creatinine ratio. Following parathyroidectomy, it was possible to observe a discrepancy between markers of bone resorption and those of bone formation. The former tend to decrease, while the latter either do not show any significant change (serum alkaline phosphatase and serum osteocalcin) or increase (serum procollagen). The results of our investigation indicate that in basal conditions the assay of serum procollagen may be of clinical value but it would be better to use it in combination with other biomarkers of skeletal remodelling. The results obtained after parathyroidectomy are the opposite of those obtained following parathyroid hormone infusion and should be ascribed to the effect of acute hormone deficiency on collagen synthesis. The positive biochemical uncoupling following surgery might lend support to the rise of bone mineral density consistently reported in the first few months following parathyroidectomy. S Minisola, Istituto di II Clinical Medica, Policlinico Umberto I, Via del Policlinico 155, 00161 Rome, Italy

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Serum Levels of the Carboxy-Tervninal Propeptide of Type I Procollagen and the Pyridinoline Cross-Linked Carboxy-Terminal Telopeptide of Type I Collagen as Markers of Bone Metastases in Patients with Prostate Carcinoma

European Urology ◽

10.1159/000474454 ◽

1997 ◽

Vol 31 (2) ◽

pp. 220-223 ◽

Cited By ~ 5

Author(s):

Yoshikatsu Hosoya ◽

Kyoko Arai ◽

Mikihiko Honda ◽

Shuhei Sumi ◽

Ken-ichiro Yoshida

Keyword(s):

Bone Metastases ◽

Prostate Carcinoma ◽

Type I Collagen ◽

Serum Levels ◽

Type I ◽

Type I Procollagen ◽

Carboxy Terminal

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Comparison between serum levels of bone alkaline phosphatase and the carboxy-terminal propeptide of type I procollagen as markers of bone formation in patients following renal transplantation

Clinica Chimica Acta ◽

10.1016/0009-8981(95)06109-q ◽

1995 ◽

Vol 239 (2) ◽

pp. 143-151 ◽

Cited By ~ 8

Author(s):

Wolfgang Withold ◽

Stefan Degenhardt ◽

Bernd Grabensee ◽

Hans Reinauer

Keyword(s):

Alkaline Phosphatase ◽

Renal Transplantation ◽

Bone Formation ◽

Serum Levels ◽

Bone Alkaline Phosphatase ◽

Type I ◽

Type I Procollagen ◽

Carboxy Terminal ◽

Markers Of Bone Formation

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Reduced Serum Levels of Bone Formation Marker P1NP in Psoriasis

Frontiers in Medicine ◽

10.3389/fmed.2021.730164 ◽

2021 ◽

Vol 8 ◽

Author(s):

Julia Mentzel ◽

Tabea Kynast ◽

Johannes Kohlmann ◽

Holger Kirsten ◽

Matthias Blüher ◽

...

Keyword(s):

Bone Formation ◽

Bone Metabolism ◽

Type I Collagen ◽

Skin Inflammation ◽

Serum Levels ◽

Serum Markers ◽

Chronic Inflammatory Disease ◽

Type I ◽

Patient Counseling ◽

Type I Procollagen

Psoriasis is a chronic inflammatory disease of the skin and joints. More recent data emphasize an association with dysregulated glucose and fatty acid metabolism, obesity, elevated blood pressure and cardiac disease, summarized as metabolic syndrome. TNF-α and IL-17, central players in the pathogenesis of psoriasis, are known to impair bone formation. Therefore, the relation between psoriasis and bone metabolism parameters was investigated. Two serum markers of either bone formation—N-terminal propeptide of type I procollagen (P1NP) or bone resorption—C-terminal telopeptide of type I collagen (CTX-I)—were analyzed in a cohort of patients with psoriasis vulgaris. In patients with psoriasis, P1NP serum levels were reduced compared to gender-, age-, and body mass index-matched healthy controls. CTX-I levels were indistinguishable between patients with psoriasis and controls. Consistently, induction of psoriasis-like skin inflammation in mice decreases bone volume and activity of osteoblasts. Moreover, efficient anti-psoriatic treatment improved psoriasis severity, but did not reverse decreased P1NP level suggesting that independent of efficient skin treatment psoriasis did affect bone metabolism and might favor the development of osteoporosis. Taken together, evidence is provided that bone metabolism might be affected by psoriatic inflammation, which may have consequences for future patient counseling and disease monitoring.

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