scholarly journals Is There a Relation Between Triglyceride Concentrations in Very Low Density Lipoprotein and the Index of Insulin Resistance in Nondiabetic Subjects?

2014 ◽  
Vol 28 (4) ◽  
pp. 269-274 ◽  
Author(s):  
Yoshifumi Kurosaki ◽  
Tomoaki Tsukushi ◽  
Shinichi Munekata ◽  
Yuhsaku Kanoh ◽  
Tatsumi Moriya ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Very Low Density Lipoprotein ◽  
Low Density

scholarly journals Mechanisms of Hepatic Very Low Density Lipoprotein Overproduction in Insulin Resistance

2000 ◽  
Vol 275 (12) ◽  
pp. 8416-8425 ◽  
Author(s):  
Changiz Taghibiglou ◽  
André Carpentier ◽  
Stephen C. Van Iderstine ◽  
Biao Chen ◽  
Debbie Rudy ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Very Low Density Lipoprotein ◽  
Low Density

Mechanisms of Hepatic Very Low-Density Lipoprotein Overproduction in Insulin Resistance

2001 ◽  
Vol 11 (5) ◽  
pp. 170-176 ◽  
Author(s):  
Khosrow Adeli ◽  
Changiz Taghibiglou ◽  
Stephen C Van Iderstine ◽  
Gary F Lewis
Keyword(s):  
Insulin Resistance ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Very Low Density Lipoprotein ◽  
Low Density

scholarly journals Very Low Density Lipoprotein Metabolism and Plasma Adiponectin as Predictors of High-Density Lipoprotein Apolipoprotein A-I Kinetics in Obese and Nonobese Men

2009 ◽  
Vol 94 (3) ◽  
pp. 989-997 ◽  
Author(s):  
Dick C. Chan ◽  
P. Hugh R. Barrett ◽  
Esther M. M. Ooi ◽  
Juying Ji ◽  
Doris T. Chan ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
High Density Lipoprotein ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Density ◽  
Very Low Density Lipoprotein ◽  
Low Density ◽  
Plasma Adiponectin ◽  
Amyloid A ◽  
Vldl Metabolism

Abstract Context: Hypercatabolism of high-density lipoprotein (HDL) apolipoprotein (apo) A-I results in low plasma apoA-I concentration. The mechanisms regulating apoA-I catabolism may relate to alterations in very low density lipoprotein (VLDL) metabolism and plasma adiponectin and serum amyloid A protein (SAA) concentrations. Objective: We examined the associations between the fractional catabolic rate (FCR) of HDL-apoA-I and VLDL kinetics, plasma adiponectin, and SAA concentrations. Study Design: The kinetics of HDL-apoA-I and VLDL-apoB were measured in 50 obese and 37 nonobese men using stable isotopic techniques. Results: In the obese group, HDL-apoA-I FCR was positively correlated with insulin, homeostasis model of assessment for insulin resistance (HOMA-IR) score, triglycerides, VLDL-apoB, and VLDL-apoB production rate (PR). In the nonobese group, HDL-apoA-I FCR was positively correlated with triglycerides, apoC-III, VLDL-apoB, and VLDL-apoB PR and negatively correlated with plasma adiponectin. Plasma SAA was not associated with HDL-apoA-I FCR in either group. In multiple regression analyses, VLDL-apoB PR and HOMA-IR score, and VLDL-apoB PR and adiponectin were independently predictive of HDL-apoA-I FCR in the obese and nonobese groups, respectively. HDL-apoA-I FCR was positively and strongly associated with HDL-apoA-I PR in both groups. Conclusions: Variation in VLDL-apoB production, and hence plasma triglyceride concentrations, exerts a major effect on the catabolism of HDL-apoA-I. Insulin resistance and adiponectin may also contribute to the variation in HDL-apoA-I catabolism in obese and nonobese subjects, respectively. We also hypothesize that apoA-I PR determines a steady-state, lowered plasma of apoA-I, which may reflect a compensatory response to a primary defect in the catabolism of HDL-apoA-I due to altered VLDL metabolism.

scholarly journals Dyslipidemia is the hallmark of the metabolic syndrome in postmenopausal women

2020 ◽  
Vol 4 (2) ◽  
pp. 18-21
Author(s):  
Asim Alaaeldin Osman ◽  
Ahmed Mohamed Fadlalla
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Total Cholesterol ◽  
Postmenopausal Women ◽  
Lipid Accumulation ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Significant Negative Correlation ◽  
Very Low Density Lipoprotein ◽  
Low Density

The incidence of cardiovascular diseases (CVD) increases after menopause and may be due to changes in the plasma lipid-lipoprotein levels that occur following menopausal transition. Physiological estrogen withdrawal during menopause plays a major role in abnormal lipid metabolism such as elevated low-density lipoprotein concentration. The aim of this study was to determine the relationship between dyslipidemia and the causative factors of metabolic syndrome in postmenopausal women. In this cross-sectional study, 290 postmenopausal Sudanese women were included. Lipid profiles were measured by spectrophotometer, estrogen hormone determined by ELISA, insulin resistance determined by HOMA-2 calculator and lipid accumulation product was calculated by the following equation (waist circumference in cm X triglyceride concentration in mM). The results revealed that total cholesterol, triglycerides, low-density lipoprotein levels and very low-density lipoprotein levels were significantly higher in the postmenopausal women with metabolic syndrome (MS) in comparison to those without the MS. Elevated total cholesterol levels were seen in 51.7 %, elevated triglycerides were seen in 49.7% and elevated low-density lipoprotein levels were seen in 29.3% whereas reduced high density lipoprotein levels were seen in 16.89% of the postmenopausal women. Total cholesterol, triglycerides and very low-density lipoprotein values showed a significant positive correlation with insulin resistance and lipid accumulation and a significant negative correlation with the estrogen hormone level. In addition, high density lipoproteins showed a significant negative correlation with lipid accumulation levels.

scholarly journals Apolipoprotein AII Is a Regulator of Very Low Density Lipoprotein Metabolism and Insulin Resistance

2007 ◽  
Vol 283 (17) ◽  
pp. 11633-11644 ◽  
Author(s):  
Lawrence W. Castellani ◽  
Cara N. Nguyen ◽  
Sarada Charugundla ◽  
Michael M. Weinstein ◽  
Chau X. Doan ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Low Density Lipoprotein ◽  
Lipoprotein Metabolism ◽  
Density Lipoprotein ◽  
Very Low Density Lipoprotein ◽  
Low Density
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