scholarly journals Diagnostic accuracy of fecal calprotectin in predicting significant gastrointestinal diseases

JGH Open ◽  
2021 ◽  
Author(s):  
Yee Man Kan ◽  
Sin Yan Chu ◽  
Ching Kong Loo
Keyword(s):  
Diagnostic Accuracy ◽  
Gastrointestinal Diseases ◽  
Fecal Calprotectin

scholarly journals Optimal Range of Fecal Calprotectin for Predicting Mucosal Healing in Patients with Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis

2021 ◽  
pp. 1-11
Author(s):  
Bing-Jie Xiang ◽  
Min Jiang ◽  
Ming-Jun Sun ◽  
Cong Dai
Keyword(s):  
Inflammatory Bowel Disease ◽  
Diagnostic Accuracy ◽  
Likelihood Ratio ◽  
Sensitivity And Specificity ◽  
Bowel Disease ◽  
Meta Analysis ◽  
Positive Likelihood Ratio ◽  
Fecal Calprotectin ◽  
Mucosal Healing ◽  
Inflammatory Bowel

<b><i>Objective:</i></b> Fecal calprotectin (FC) is a promising marker for assessment of inflammatory bowel disease (IBD) activity. However, the utility of FC for predicting mucosal healing (MH) of IBD patients has yet to be clearly demonstrated. The objective of our study was to perform a meta-analysis evaluating the diagnostic accuracy of FC in predicting MH of IBD patients. <b><i>Methods:</i></b> We systematically searched the databases for studies from inception to April 2020 that evaluated MH in IBD. The methodological quality of each study was assessed according to the Quality Assessment of Diagnostic Accuracy Studies checklist. The extracted data were pooled using a summary receiver operating characteristic curve model. Random-effects model was used to summarize the diagnostic odds ratio, sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio. <b><i>Results:</i></b> Sixteen studies comprising 1,682 ulcerative colitis (UC) patients and 4 studies comprising 221 Crohn’s disease (CD) patients were included. The best performance of FC for predicting MH in UC was at cut-off range of 60–75 μg/g with area under the curve (AUC) of 0.88 and pooled sensitivity and specificity of 0.87 and 0.79, respectively. The pooled sensitivity and specificity values of cutoff range 180–250 μg/g for predicting MH in CD were 0.67 and 0.76, respectively. The AUC of 0.79 also revealed improved discrimination for identifying MH in CD with FC concentration. <b><i>Conclusion:</i></b> Our meta-analysis has found that FC is a simple, reliable noninvasive marker for predicting MH in IBD patients. FC cutoff range 60–75 μg/g appears to have the best overall accuracy in UC patients.

scholarly journals Challenges in diagnostic accuracy studies in primary care: the fecal calprotectin example

2013 ◽  
Vol 14 (1) ◽  
Author(s):  
Gea A Holtman ◽  
Leeuwen Yvonne Lisman-van ◽  
Boudewijn J Kollen ◽  
Johanna C Escher ◽  
Angelika Kindermann ◽  
...  
Keyword(s):  
Primary Care ◽  
Diagnostic Accuracy ◽  
Fecal Calprotectin

04 DIAGNOSTIC ACCURACY OF THE SERUM-BASED MUCOSAL HEALING INDEX ASSAY IN CROHN’S DISEASE AND COMPARATIVE ACCURACY TO FECAL CALPROTECTIN IN ROUTINE PRACTICE

2019 ◽  
Vol 25 (Supplement_1) ◽  
pp. S14-S14
Author(s):  
Robert Battat ◽  
Brigid Boland ◽  
Siddharth Singh ◽  
Angelina Collins ◽  
Elisabeth R Evans ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Diagnostic Accuracy ◽  
Fecal Calprotectin ◽  
Mucosal Healing ◽  
Routine Practice ◽  
Healing Index ◽  
Comparative Accuracy

scholarly journals Improving the Preoperative Diagnostic Accuracy of Acute Appendicitis. Can Fecal Calprotectin Be Helpful?

PLoS ONE ◽  
2016 ◽  
Vol 11 (12) ◽  
pp. e0168769 ◽  
Author(s):  
Peter C. Ambe ◽  
Valerie Orth ◽  
Daniel Gödde ◽  
Hubert Zirngibl
Keyword(s):  
Acute Appendicitis ◽  
Diagnostic Accuracy ◽  
Fecal Calprotectin ◽  
Preoperative Diagnostic

scholarly journals Diagnostic Accuracy of Five Different Fecal Markers for the Detection of Precancerous and Cancerous Lesions of the Colorectum

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Mariann Rutka ◽  
Renáta Bor ◽  
Anita Bálint ◽  
Anna Fábián ◽  
Ágnes Milassin ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Diagnostic Accuracy ◽  
Sensitivity And Specificity ◽  
Fecal Calprotectin ◽  
Colorectal Adenomas ◽  
Human Hemoglobin ◽  
Combined Use ◽  
Fecal Markers ◽  
Stool Samples ◽  
Metalloproteinase 9

Background.Colorectal cancer (CRC) is the second deadliest malignancy worldwide. This study aimed to compare the diagnostic accuracy of different fecal markers in the detection of colorectal adenomas and cancer.Methods.Stool samples of patients referred to colonoscopy were collected for the analysis of tumor M2pyruvate kinase (M2PK), human hemoglobin (Hb), hemoglobin/haptoglobin (Hb/Hp) complex, fecal calprotectin (FC), and matrix metalloproteinase-9 (MMP-9).Results.Sensitivity and specificity of M2PK for adenomas sized > 1 cm were 60% and 67.5% and for CRC were 94.7% and 67.5%. Sensitivity and specificity of iFOBT for adenomas sized ≥ 1 cm were 80% and 72.5% and for CRC were 94.7% and 72.5%. Sensitivity and specificity of Hb/Hp complex for adenomas sized ≥ 1 cm were 80% and 52.9% and for CRC were 100% and 52.9%. Sensitivity of FC and MMP-9 for CRC was 77.8% and 72.2%. Combined use of M2PK, iFOBT, and FC resulted in a sensitivity and specificity of 95% and 47.5% for the detection of adenomas sized ≥ 1 cm.Discussion.In CRC, sensitivity of M2PK, iFOBT, and Hb/Hp complex proved to be high. Combined use of M2PK, iFOBT, and FC may be valuable in the detection of large adenomas.

scholarly journals A székletkalprotektin meghatározásának szerepe a bélbetegségek diagnosztikájában és kezelésében

2019 ◽  
Vol 160 (9) ◽  
pp. 322-328
Author(s):  
Ákos Iliás ◽  
Fióna Petra Rózsa ◽  
Lóránt Gönczi ◽  
Barbara Dorottya Lovász ◽  
Zsuzsanna Kürti ◽  
...  
Keyword(s):  
Clinical Symptoms ◽  
Point Of Care ◽  
Short Review ◽  
Gastrointestinal Diseases ◽  
Fecal Calprotectin ◽  
Gastrointestinal Infections ◽  
Bowel Diseases ◽  
And Performance ◽  
Irritable Bowel

Abstract: The diagnostics of gastrointestinal diseases have evolved significantly in the past few decades. Besides endoscopy and conventional imaging modalities, there is a growing interest for rapid point-of-care laboratory tests to help discriminate between diseases with similar clinical symptoms and/or help the follow-up of chronic conditions, predicting relapses. The fecal calprotectin testing is a routine diagnostic tool in many countries. It is also more and more accessible in Hungary as well. We aim to present a short review on the role and performance of fecal calprotectin test in the diagnosis and follow-up of gastrointestinal diseases, especially inflammatory bowel diseases, gastrointestinal infections, irritable bowel syndrome and pediatric conditions. By presenting the different cut-off values, sensitivity and specificity rates representative for each disease, we hope to further aid clinicians in decision-making regarding these conditions. Orv Hetil. 2019; 160(9): 322–328.

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