Cultured Human Alveolar Macrophages From Smokers With Lung Cancer: Resolution of Factors That Stimulate Fibroblast Proliferation, Production of Collagenase, or Prostaglandin E2

1985 ◽  
Vol 37 (5) ◽  
pp. 641-649 ◽  
Author(s):  
J.-M. Dayer ◽  
L. Sundstrm ◽  
B.S. Polla ◽  
A.F. Junod
1989 ◽  
Vol 256 (5) ◽  
pp. C1012-C1015 ◽  
Author(s):  
G. K. Iwamoto ◽  
M. M. Monick ◽  
L. F. Burmeister ◽  
G. W. Hunninghake

These studies utilized a sensitive and specific radioimmunoassay for interleukin 1 beta (IL-1 beta) to compare release of IL-1 by human alveolar macrophages and blood monocytes. The studies demonstrate that alveolar macrophages release amounts of antigenic IL-1 beta that are similar to that of blood monocytes. The amounts of IL-1 released were similar for both cell types at early (4 h) and late (24 h) time points and with differing amounts of stimuli [endotoxin; lipopolysaccharide (LPS)]. In addition, alveolar macrophages actually produced more total IL-1 (intracellular IL-1 plus released IL-1) than did blood monocytes. Alveolar macrophages that were stimulated with LPS released significantly more prostaglandin E2 (PGE2, an inhibitor of IL-1) than did blood monocytes. These studies demonstrate that human alveolar macrophages are not defective in their capacity to release IL-1.


CHEST Journal ◽  
1991 ◽  
Vol 100 (5) ◽  
pp. 1277-1280 ◽  
Author(s):  
Hidetaka Kawatsu ◽  
Yoshinori Hasegawa ◽  
Eishi Takagi ◽  
Kaoru Shimokata

Lung ◽  
1986 ◽  
Vol 164 (1) ◽  
pp. 355-364 ◽  
Author(s):  
N. Clerici ◽  
F. Leyva-Cobián ◽  
S. Reboiras ◽  
P. Lázaro de Mercado

1986 ◽  
Vol 37 (4) ◽  
pp. 525-529 ◽  
Author(s):  
Nicola Semeraro ◽  
Onofrio De Lucia ◽  
Angela Lattanzio ◽  
Pasqualina Montemurro ◽  
Domenico Giordano ◽  
...  

Pneumologie ◽  
2010 ◽  
Vol 64 (S 03) ◽  
Author(s):  
S Stenger ◽  
D Nickel ◽  
M Wagner ◽  
JH Ficker ◽  
C Schumann

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