Kinetic Analysis of Glycyrrhetic Acid, an Active Metabolite of Glycyrrhizin, in Rats: Role of Enterohepatic Circulation

1993 ◽  
Vol 82 (3) ◽  
pp. 301-305 ◽  
Author(s):  
Junichi Kawakami ◽  
Yoshikazu Yamamura ◽  
Tomofumi Santa ◽  
Hajime Kotaki ◽  
Katsuyoshi Uchino ◽  
...  
Keyword(s):  
Kinetic Analysis ◽  
Active Metabolite ◽  
Enterohepatic Circulation ◽  
Glycyrrhetic Acid

The role of the active metabolite of vitamin D (alfacalcidol) in the treatment of deficiency states and functional disorders

2015 ◽  
Vol 17 (9) ◽  
pp. 139-143
Author(s):  
I.S. Dydykina ◽  
◽  
P.S. Dydykina ◽  
A.A. Kovalenko ◽  
◽  
...  
Keyword(s):  
Vitamin D ◽  
Active Metabolite ◽  
Functional Disorders

scholarly journals Role of FXR in Bile Acid and Metabolic Homeostasis in NASH: Pathogenetic Concepts and Therapeutic Opportunities

2021 ◽  
Author(s):  
Richard Radun ◽  
Michael Trauner
Keyword(s):  
Liver Disease ◽  
Bile Acid ◽  
Enterohepatic Circulation ◽  
Therapeutic Potential ◽  
Farnesoid X Receptor ◽  
Metabolic Homeostasis ◽  
Nonalcoholic Fatty Liver ◽  
Metabolic Dysregulation ◽  
Attractive Therapeutic Target

AbstractNonalcoholic fatty liver disease (NAFLD) has become the most prevalent cause of liver disease, increasingly contributing to the burden of liver transplantation. In search for effective treatments, novel strategies addressing metabolic dysregulation, inflammation, and fibrosis are continuously emerging. Disturbed bile acid (BA) homeostasis and microcholestasis via hepatocellular retention of potentially toxic BAs may be an underappreciated factor in the pathogenesis of NAFLD and nonalcoholic steatohepatitis (NASH) as its progressive variant. In addition to their detergent properties, BAs act as signaling molecules regulating cellular homeostasis through interaction with BA receptors such as the Farnesoid X receptor (FXR). Apart from being a key regulator of BA metabolism and enterohepatic circulation, FXR regulates metabolic homeostasis and has immune-modulatory effects, making it an attractive therapeutic target in NAFLD/NASH. In this review, the molecular basis and therapeutic potential of targeting FXR with a specific focus on restoring BA and metabolic homeostasis in NASH is summarized.

Kinetic analysis of the role of selective NOx recirculation in reducing NOx emissions from a hydrogen engine

2019 ◽  
Vol 377 ◽  
pp. 120143
Author(s):  
Sunil K. Rawat ◽  
Vaibhav Srivastava ◽  
Divesh Bhatia
Keyword(s):  
Kinetic Analysis ◽  
Nox Emissions

scholarly journals Kinetic Analysis of the Effect of Poliovirus Receptor on Viral Uncoating: the Receptor as a Catalyst

2001 ◽  
Vol 75 (11) ◽  
pp. 4984-4989 ◽  
Author(s):  
Simon K. Tsang ◽  
Brian M. McDermott ◽  
Vincent R. Racaniello ◽  
James M. Hogle
Keyword(s):  
Activation Energy ◽  
Transition State ◽  
Kinetic Analysis ◽  
Transition State Theory ◽  
State Theory ◽  
Viral Receptor ◽  
Poliovirus Receptor ◽  
Entropic Stabilization ◽  
Entropic Effects

ABSTRACT We examined the role of soluble poliovirus receptor on the transition of native poliovirus (160S or N particle) to an infectious intermediate (135S or A particle). The viral receptor behaves as a classic transition state theory catalyst, facilitating the N-to-A conversion by lowering the activation energy for the process by 50 kcal/mol. In contrast to earlier studies which demonstrated that capsid-binding drugs inhibit thermally mediated N-to-A conversion through entropic stabilization alone, capsid-binding drugs are shown to inhibit receptor-mediated N-to-A conversion through a combination of enthalpic and entropic effects.

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