The prognostic implications of primary colorectal tumor location on recurrence and overall survival in patients undergoing resection for colorectal liver metastasis

2016 ◽  
Vol 114 (7) ◽  
pp. 803-809 ◽  
Author(s):  
Kazunari Sasaki ◽  
Nikolaos Andreatos ◽  
Georgios A. Margonis ◽  
Jin He ◽  
Matthew Weiss ◽  
...  
Keyword(s):  
Overall Survival ◽  
Liver Metastasis ◽  
Colorectal Liver Metastasis ◽  
Tumor Location ◽  
Colorectal Tumor ◽  
Primary Colorectal Tumor ◽  
Prognostic Implications

scholarly journals Association of Race/Ethnicity With Overall Survival Among Patients With Colorectal Liver Metastasis

2020 ◽  
Vol 3 (9) ◽  
pp. e2016019
Author(s):  
Lucas W. Thornblade ◽  
Susanne Warner ◽  
Laleh Melstrom ◽  
Gagandeep Singh ◽  
Yuman Fong ◽  
...  
Keyword(s):  
Overall Survival ◽  
Liver Metastasis ◽  
Colorectal Liver Metastasis ◽  
Race Ethnicity

Surgical treatment of extra-appendiceal colorectal neuroendocrine tumors.

2018 ◽  
Vol 90 (3) ◽  
pp. 7-12 ◽  
Author(s):  
Jan Maryański ◽  
Agata Cyran-Chlebicka ◽  
Benedykt Szczepankiewicz ◽  
Włodzimierz Cebulski ◽  
Maciej Słodkowski ◽  
...  
Keyword(s):  
Overall Survival ◽  
Median Survival ◽  
Neuroendocrine Tumors ◽  
Distant Metastases ◽  
Tumor Location ◽  
Biological Behavior ◽  
Lower Grade ◽  
Prognostic Implications ◽  
Neuroendocrine Carcinomas

Background: Extra-appendiceal colorectal neuroendocrine tumors are rare neoplasms with a variable biological behavior. Materials and Methods: The study group consisted of 15 patients with an extra-appendiceal colorectal neuroendocrine tumor who underwent surgical resection (M/F=3:12, mean age=62.9 years). Lower-grade neuroendocrine tumors and neuroendocrine carcinomas were recognized in 5 and 10 patients, respectively. Data were evaluated retrospectively with regard to clinical and pathologic characteristics and outcomes. Results: The median age of the patients with lower-grade NETs was significantly lower than that in patients with NECs (53 yr vs. 68 yr, p=0.03). NETs G1-G2 were significantly smaller than neuroendocrine carcinomas (4.0 cm vs. 6.4 cm, p=0.02). There were no differences between lower-grade NETs and NECs with regard to tumor location, rate of nodal involvement and distant metastases. All the patients underwent open segmental resection of the colon or rectum. Complete resection was achieved in 3 of 5 patients from the lower-grade NET group, and in 5 of 10 patients in the NEC group. Overall survival was significantly better for lower-grade NETs tumors (p=0.005). The median survival was 4.8 months in the NEC group. The median survival in the lower-grade NET group was not achieved after a median follow-up of 69 months. Three-year overall survival was 100% for lower-grade NETs, and only 27% for NECs. Conclusion: Lower-grade neuroendocrine tumors seem to exhibit comparable potential for dissemination as neuroendocrine carcinomas, but prognostic implications of metastases are distinct.

Overall survival by pattern of recurrence following curative intent surgery for colorectal liver metastasis

2014 ◽  
Vol 110 (8) ◽  
pp. 1011-1015 ◽  
Author(s):  
Afif N. Kulaylat ◽  
Jane R. Schubart ◽  
Audrey L. Stokes ◽  
Neil H. Bhayani ◽  
Joyce Wong ◽  
...  
Keyword(s):  
Overall Survival ◽  
Liver Metastasis ◽  
Colorectal Liver Metastasis ◽  
Curative Intent ◽  
Pattern Of Recurrence

scholarly journals The impact of primary tumor location in patients with resected colorectal liver metastasis

2018 ◽  
Vol 29 ◽  
pp. v79
Author(s):  
V. Pacheco-Barcia ◽  
O. Donnay ◽  
R. Mondéjar Solís ◽  
R. Serrano ◽  
E. Martin ◽  
...  
Keyword(s):  
Liver Metastasis ◽  
Colorectal Liver Metastasis ◽  
Primary Tumor ◽  
Tumor Location ◽  
Primary Tumor Location ◽  
The Impact

Survival investigation in patients with colorectal liver metastasis: A single-institution analysis.

2012 ◽  
Vol 30 (4_suppl) ◽  
pp. 617-617
Author(s):  
Jianmin Xu ◽  
Dexiang Zhu ◽  
Li Ren ◽  
Ye Wei
Keyword(s):  
Liver Resection ◽  
Liver Metastasis ◽  
Liver Metastases ◽  
Median Survival ◽  
Colorectal Liver Metastasis ◽  
Survival Rates ◽  
Term Survival ◽  
Long Term Survival ◽  
Primary Colorectal Tumor

617 Background: To investigate survival in patients with colorectal liver metastasis (CRLM) and identify risk factors associated with survival. Methods: Clinical, pathologic, treatment and complete follow-up data were retrospectively collected from 1613 consecutive patients with CRLM in Zhongshan Hospital between 2000 and 2010. The prognostic value of different factors was studied through univariate and multivariate analyses. Results: The median survival was 22.0 mo and 5-yr survival rate was 16%. Survival of synchronous liver metastases (SLM) (21.2 mo and 16%) was lower than that of metachronous liver metastases (MLM) (30.1 mo and 23%, p<0.01). Survival after resection of liver metastases was 49.8 mo and 37%, higher than that after chemotherapy (22.2 mo and 0%), that after intervention(19.0 mo and 11%), that after chemotherapy combined with intervention(22.8 mo and 10%)and that after local regional treatment (28.5 mo and 0%). Expansion of the indications for liver resection (38.0 vs 48.0 mo, 32% vs 40%), simultaneous or staged resection of primary colorectal tumor and liver metastases (47.0 vs 44.0 mo, 33% vs 35%) and preoperative neoadjuvant therapy (44.0 vs 48.0 mo, 38% vs 36%) had no significant effect on survival. 64 initially irresectable patients could undergo surgery after convertible therapy, with the median survival 36.9 mo and 5-yr survival 30%, better than that of unresectable patients (18.2 mo and 8%). Five factors were found to be significant and independent predictors of poor survival by multivariate analysis: SLM, poorly differentiated primary, number of liver metastases >= 4, largest liver metastases >= 5 cm, and no surgical treatment of liver metastases. Giving one point to each above factor, the population was divided into six groups with 5-yr survival rates: 0 (64%), 1 (44%), 2 (29%), 3 (4%), 4 (4%) and 5 (1%) (p<0.01). Conclusions: Survival of SLM was lower than that of MLM. Resection of liver metastases provides good long-term survival benifit for patients with resectable and initially irresectable liver metastases. Expansion of the indications for liver resection is acceptable. Long-term survival outcome can be predicted from a risk factor scoring system.

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