scholarly journals Expanded criteria for liver transplantation in patients with hepatocellular carcinoma: A report from the International Registry of Hepatic Tumors in Liver Transplantation

2007 ◽  
Vol 13 (3) ◽  
pp. 391-399 ◽  
Author(s):  
Nicholas Onaca ◽  
Gary L. Davis ◽  
Robert M. Goldstein ◽  
Linda W. Jennings ◽  
Göran B. Klintmalm
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Hepatic Tumors ◽  
International Registry ◽  
Expanded Criteria

Improved results of transplantation for hepatocellular carcinoma: A report from the international registry of hepatic tumors in liver transplantation

2009 ◽  
Vol 15 (6) ◽  
pp. 574-580 ◽  
Author(s):  
Nicholas Onaca ◽  
Gary L. Davis ◽  
Linda W. Jennings ◽  
Robert M. Goldstein ◽  
Goran B. Klintmalm
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Hepatic Tumors ◽  
International Registry

Expanded Criteria for Liver Transplantation in Patients With Hepatocellular Carcinoma

2006 ◽  
Vol 38 (2) ◽  
pp. 575-578 ◽  
Author(s):  
H. Karakayali ◽  
G. Moray ◽  
H. Sozen ◽  
A. Dalgic ◽  
R. Emiroglu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Expanded Criteria

scholarly journals Living donor liver transplantation for hepatocellular carcinoma beyond the Milan criteria: outcome of expanded criteria in tumor size

BMC Surgery ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Hsin-Rou Liang ◽  
Chia-En Hsieh ◽  
Kuo-Hua Lin ◽  
Chih-Jan Ko ◽  
Yu-Ju Hung ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Living Donor ◽  
Milan Criteria ◽  
Tumor Diameter ◽  
Donor Liver ◽  
Donor Liver Transplantation ◽  
Living Donor Liver Transplant ◽  
Expanded Criteria ◽  
Donor Liver Transplant

Abstract Background The Milan criteria are the universal standard of liver transplantation for hepatocellular carcinoma (HCC). Numerous expanded criteria have shown outcomes as good as the Milan criteria. In Taiwan, living donor liver transplant (LDLT) accounts for the majority of transplantations due to organ shortages. Methods We retrospectively enrolled 155 patients who underwent LDLT for HCC from July 2005 to June 2017 and were followed up for at least 2 years. Patients beyond the Milan criteria (n = 78) were grouped as recurrent or nonrecurrent, and we established new expanded criteria based on these data. Results Patients beyond the Milan criteria with recurrence (n = 31) had a significantly larger maximal tumor diameter (4.13 ± 1.96 cm versus 6.10 ± 3.41 cm, p = 0.006) and total tumor diameter (7.19 ± 4.13 cm versus 10.21 ± 5.01 cm, p = 0.005). Therefore, we established expanded criteria involving maximal tumor diameter ≤ 6 cm and total tumor diameter < 10 cm. The 5-year survival rate of patients who met these criteria (n = 134) was 77.3%, and the 5-year recurrence rate was 20.5%; both showed no significant differences from those of the Milan criteria. Under the expanded criteria, the pool of eligible recipients was 35% larger than that of the Milan criteria. Conclusion Currently, patients with HCC who undergo LDLT can achieve good outcomes even when they are beyond the Milan criteria. Under the new expanded criteria, patients can achieve outcomes as good as those with the Milan criteria and more patients can benefit.

Liver Transplantation and Tacrolimus Monotherapy for Hepatocellular Carcinoma With Expanded Criteria

2005 ◽  
Vol 37 (7) ◽  
pp. 3154-3156 ◽  
Author(s):  
A. Dalgic ◽  
H. Karakayali ◽  
G. Moray ◽  
R. Emiroglu ◽  
H. Sozen ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Expanded Criteria

Expanded Criteria for Hepatocellular Carcinoma Through Down-Staging Prior to Liver Transplantation: Not Yet There

2006 ◽  
Vol 26 (3) ◽  
pp. 248-253 ◽  
Author(s):  
Josep Llovet ◽  
Myron Schwartz ◽  
Josep Fuster ◽  
Jordi Bruix
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Expanded Criteria

scholarly journals Liver Transplantation in Patients with Hepatocellular Carcinoma beyond the Milan Criteria: A Comprehensive Review

2021 ◽  
Vol 10 (17) ◽  
pp. 3932
Author(s):  
Pierluigi Toniutto ◽  
Elisa Fumolo ◽  
Ezio Fornasiere ◽  
Davide Bitetto
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Selection Criterion ◽  
Surrogate Marker ◽  
Tumor Burden ◽  
Current Data ◽  
Milan Criteria ◽  
Biological Variables ◽  
Expanded Criteria ◽  
Histological Characteristics

The Milan criteria (MC) were developed more than 20 years ago and are still considered the benchmark for liver transplantation (LT) in patients with hepatocellular carcinoma (HCC). However, the strict application of MC might exclude some patients who may receive a clinical benefit of LT. Several expanded criteria have been proposed. Some of these consider pretransplant morphological and biological variables of the tumor, others consider post-LT variables such as the histology of the tumor, and others combine pre- and post-LT variables. More recently, the HCC response to locoregional treatments before transplantation emerged as a surrogate marker of the biological aggressiveness of the tumor to be used as a better selection criterion for LT in patients beyond the MC at presentation. This essential review aims to present the current data on the pretransplant selection criteria for LT in patients with HCC exceeding the MC at presentation based on morphological and histological characteristics of the tumor and to critically discuss those that have been validated in clinical practice. Moreover, the role of HCC biological markers and the tumor response to downstaging procedures as new tools for selecting patients with a tumor burden outside of the MC for LT is evaluated.

T1932 Expanded Criteria for Liver Transplantation in Cirrhotic Patients with Hepatocellular Carcinoma

2008 ◽  
Vol 134 (4) ◽  
pp. A-825
Author(s):  
Maurício Silva ◽  
Angel Moya ◽  
Marina Berenguer ◽  
Martin Prieto ◽  
Fernando Sanjuan ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Expanded Criteria ◽  
Cirrhotic Patients

scholarly journals Impact of Brazilian expanded criteria for liver transplantation in patients with hepatocellular carcinoma: a multicenter study

2020 ◽  
pp. 100294
Author(s):  
Aline L. Chagas ◽  
Angelo A. Mattos ◽  
Márcio A. Diniz ◽  
Guilherme E.G. Felga ◽  
Ilka F.S.F. Boin ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Multicenter Study ◽  
Expanded Criteria

scholarly journals Author Correction: Liver Transplantation for Hepatocellular Carcinoma: Malatya Experience and Proposals for Expanded Criteria

2020 ◽  
Vol 51 (3) ◽  
pp. 1006-1006
Author(s):  
Volkan Ince ◽  
Sami Akbulut ◽  
Emrah Otan ◽  
Veysel Ersan ◽  
Serdar Karakas ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Expanded Criteria
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