Combining Ultra‐High Drug‐Loaded Micelles and Injectable Hydrogel Drug Depots for Prolonged Drug Release

Hydrogel based drug depot formulations are of great interest for therapeutic applications. Here, the impact of incorporated drug, neat polymer micelles, and drug-loaded micelles on the viscoelastic properties of a cytocompatible hydrogel was investigated systematically. To challenge the hydrogel with regard to the desired application as injectable drug depot, curcumin (CUR) was chosen as a model compound due to its very low-water solubility and limited stability. CUR was either directly solubilized by the hydrogel or pre-incorporated into polymer micelles. Drug-release from a collagen matrix was studied in a trans-well setup and extended drug release over 10 weeks.<br>

Download Full-text

Combining Ultra-High Drug Loaded Micelles and Shear Thinning, Injectable Hydrogel Drug Depots for Prolonged Drug Release

10.26434/chemrxiv.8280761.v2 ◽

2019 ◽

Author(s):

Michael M Lübtow ◽

Thomas Lorson ◽

Tamara Finger ◽

Florian-Kai Gröber-Becker ◽

Robert Luxenhofer

Keyword(s):

Drug Release ◽

Viscoelastic Properties ◽

Model Compound ◽

Water Solubility ◽

Collagen Matrix ◽

Polymer Micelles ◽

Neat Polymer ◽

High Drug ◽

The Impact ◽

Prolonged Drug Release

Hydrogel based drug depot formulations are of great interest for therapeutic applications. Here, the impact of incorporated drug, neat polymer micelles, and drug-loaded micelles on the viscoelastic properties of a cytocompatible hydrogel was investigated systematically. To challenge the hydrogel with regard to the desired application as injectable drug depot, curcumin (CUR) was chosen as a model compound due to its very low-water solubility and limited stability. CUR was either directly solubilized by the hydrogel or pre-incorporated into polymer micelles. Drug-release from a collagen matrix was studied in a trans-well setup and extended drug release over 10 weeks.

Download Full-text

Combining Ultra-High Drug Loaded Micelles and Shear Thinning, Injectable Hydrogel Drug Depots for Prolonged Drug Release

10.26434/chemrxiv.8280761 ◽

2019 ◽

Author(s):

Michael M Lübtow ◽

Thomas Lorson ◽

Tamara Finger ◽

Florian-Kai Gröber-Becker ◽

Robert Luxenhofer

Keyword(s):

Drug Release ◽

Viscoelastic Properties ◽

Model Compound ◽

Water Solubility ◽

Collagen Matrix ◽

Polymer Micelles ◽

Neat Polymer ◽

High Drug ◽

The Impact ◽

Prolonged Drug Release

Hydrogel based drug depot formulations are of great interest for therapeutic applications. Here, the impact of incorporated drug, neat polymer micelles, and drug-loaded micelles on the viscoelastic properties of a cytocompatible hydrogel was investigated systematically. To challenge the hydrogel with regard to the desired application as injectable drug depot, curcumin (CUR) was chosen as a model compound due to its very low-water solubility and limited stability. CUR was either directly solubilized by the hydrogel or pre-incorporated into polymer micelles. Drug-release from a collagen matrix was studied in a trans-well setup and extended drug release over 10 weeks.<br>

Download Full-text

Development of FDM 3D-printed tablets with rapid drug release, high drug-polymer miscibility and reduced printing temperature by applying the acid-base supersolubilization (ABS) principle

International Journal of Pharmaceutics ◽

10.1016/j.ijpharm.2021.120524 ◽

2021 ◽

Vol 600 ◽

pp. 120524

Author(s):

Nirali G. Patel ◽

Abu T.M. Serajuddin

Keyword(s):

Drug Release ◽

Acid Base ◽

High Drug ◽

Polymer Miscibility ◽

3D Printed

Download Full-text

A visible-light-controlled platform for prolonged drug release based on Ag-doped TiO2 nanotubes with a hydrophobic layer

Beilstein Journal of Nanotechnology ◽

10.3762/bjnano.9.170 ◽

2018 ◽

Vol 9 ◽

pp. 1793-1801 ◽

Cited By ~ 4

Author(s):

Caihong Liang ◽

Jiang Wen ◽

Xiaoming Liao

Keyword(s):

Drug Release ◽

Visible Light ◽

Controlled Drug Release ◽

Photocatalytic Decomposition ◽

Light Illumination ◽

Visible Light Illumination ◽

Delivery Platform ◽

Promising Application ◽

Hydrophobic Layer ◽

Prolonged Drug Release

In this work, a visible-light-controlled drug release platform was constructed for localized and prolonged drug release based on two-layer titania nanotubes (TNTs) fabricated using by an in situ voltage up-anodization process. The visible-light photocatalytic activity is improved by loading Ag onto the TNTs by NaBH4 reduction. Then, the TNTs containing Ag nanoparticles were modified with dodecanethiol (NDM) to create a hydrophobic layer. To demonstrate the visible-light-controlled drug release, the Zn2+ release behavior of the samples was investigated. In the initial 12 h, TNTs without NDM displayed a faster release rate with 29.4% Zn2+ release, which was more than three times that of the TNTs with NDM (8.7% Zn2+ release). Upon visible-light illumination, drug release from the sample coated with NDM was shown to increase due to the photocatalytic decomposition of NDM. The amount of released Zn2+ for this sample increased up to 71.9% within 12 h, indicating visible-light-controlled drug release. This drug release system may exhibit promising application as a localized, prolonged drug delivery platform.

Download Full-text

MBG/PLGA composite microspheres with prolonged drug release

Journal of Biomedical Materials Research Part B Applied Biomaterials ◽

10.1002/jbm.b.31197 ◽

2009 ◽

Vol 89B (1) ◽

pp. 148-154 ◽

Cited By ~ 24

Author(s):

Xia Li ◽

Xiupeng Wang ◽

Lingxia Zhang ◽

Hangrong Chen ◽

Jianlin Shi

Keyword(s):

Drug Release ◽

Composite Microspheres ◽

Prolonged Drug Release

Download Full-text

Optoregulated Drug Release from an Engineered Living Hydrogel

10.26434/chemrxiv.7087010 ◽

2018 ◽

Author(s):

Shrikrishnan Sankaran ◽

Judith Becker ◽

Christoph Wittmann ◽

Aránzazu del Campo

Keyword(s):

Drug Release ◽

Blue Light ◽

Light Irradiation ◽

E Coli ◽

Hydrogel Matrix ◽

Prolonged Drug Release

A living hydrogel has been developed with metabolically and optogenetically engineered E. coli encapsulated within an agarose-based hydrogel matrix to produce and release deoxyviolacein in response to blue light irradiation. Localized, tunable and prolonged drug release have been demonstrated.<br>

Download Full-text

Synthesis, Characterization and Safety Profiling of Eudragit-Based pHResponsive Hydrogels: A Promising Platform for Colonic Delivery of Losartan Potassium

Current Drug Delivery ◽

10.2174/1567201816666190208165511 ◽

2019 ◽

Vol 16 (6) ◽

pp. 548-564

Author(s):

Shabina Mahmood ◽

Manal Ali Buabeid ◽

Kaleem Ullah ◽

Ghulam Murtaza ◽

Abdul Mannan ◽

...

Keyword(s):

Drug Release ◽

Acrylic Acid ◽

Drug Loading ◽

Control Group ◽

Colonic Delivery ◽

Hydrophilic Drugs ◽

Promising Tool ◽

Inverse Results ◽

Efficient Delivery ◽

Prolonged Drug Release

Objective: The aim of the present study was to design an efficient delivery system with an anticipated swelling and drug release properties for a prolonged drug release as well as to target colon for various hydrophilic drugs. Methods: For this purpose, the pH-responsive hydrogel comprising a combination of Eudragit and acrylic acid was formed. The hydrogels were characterized for spectral (FTIR), thermal (TGA/DSC), structural (XRD), and morphological (SEM) investigations. Oral tolerability was assessed in rabbits for biocompatibility and oral use of the prepared hydrogels. Results: The results showed that an increased incorporation of Eudragit and cross-linking agent retorted the swelling, drug loading, and drug release properties at both acid (pH 1.2) and basic pH (pH 6.8 and 7.4) , while acrylic acid presented the inverse results. The oral tolerability and toxicity studies depicted that the developed hydrogels were safe up to 3800 mg/kg body weight and caused no hematological or histopathological changes when compared with the control group. Conclusion: Therefore, the newly developed formulations presented adequate swelling, drug loading, release behavior, and biocompatibility properties and thus can be used as a promising tool for the colonic delivery of various hydrophilic drugs.

Download Full-text