Deep brain stimulation in acute management of status dystonicus

2009 ◽  
Vol 24 (15) ◽  
pp. 2291-2292 ◽  
Author(s):  
Robert Jech ◽  
Martin BaresÌŒ ◽  
DusÌŒan Urgošík ◽  
Olga CÌŒerná ◽  
Petr Klement ◽  
...  
2018 ◽  
Vol 33 (7) ◽  
pp. 1168-1173 ◽  
Author(s):  
Elodie Nerrant ◽  
Victoria Gonzalez ◽  
Christophe Milesi ◽  
Xavier Vasques ◽  
Diane Ruge ◽  
...  

2010 ◽  
Vol 113 (3) ◽  
pp. 634-638 ◽  
Author(s):  
Diana Apetauerova ◽  
Clemens M. Schirmer ◽  
Jay L. Shils ◽  
Janet Zani ◽  
Jeffrey E. Arle

The authors report the cases of 2 young male patients (aged 16 and 26 years) with dystonic cerebral palsy of unknown origin, who developed status dystonicus, an acute and persistent combination of generalized dystonia and chorea. Both patients developed status dystonicus after undergoing general anesthesia, and in 1 case, after administration of metoclopramide. In attempting to control this acute hyperkinetic movement disorder, multiple medication trials failed in both cases and patients required prolonged intubation and sedation with propofol. Bilateral deep brain stimulation of the globus pallidus internus (4 and 2 months after the onset of symptoms in the first and second case, respectively) produced immediate resolution of the hyperkinetic movement disorder in each case. Deep brain stimulation provided persistent suppression of the dystonic movement potential after a follow-up of 30 and 34 months, respectively, as demonstrated by the reemergence of severe dystonia during the end of battery life of the implantable pulse generators that was readily controlled by exchange of the generators in each case.


2012 ◽  
Vol 9 (1) ◽  
pp. 99-102 ◽  
Author(s):  
Brian P. Walcott ◽  
Brian V. Nahed ◽  
Kristopher T. Kahle ◽  
Ann-Christine Duhaime ◽  
Nutan Sharma ◽  
...  

Generalized dystonic syndromes may escalate into persistent episodes of generalized dystonia known as status dystonicus that can be life-threatening due to dystonia-induced rhabdomyolysis and/or respiratory compromise. Treatment of these conditions usually entails parenteral infusion of antispasmodic agents and sedatives and occasionally necessitates a medically induced coma for symptom control. The authors report a series of 3 children who presented with medically intractable, life-threatening status dystonicus and were successfully treated with bilateral pallidal deep brain stimulation. Bilateral globus pallidus internus stimulation appears to be effective in the urgent treatment of medically refractory and life-threatening movement disorders.


Neurology ◽  
2012 ◽  
Vol 78 (Meeting Abstracts 1) ◽  
pp. P01.227-P01.227 ◽  
Author(s):  
T. Cheung ◽  
V. Flatow ◽  
S. Ben-Haim ◽  
I. Osborn ◽  
C. Cho ◽  
...  

2012 ◽  
Vol 18 ◽  
pp. S150
Author(s):  
T. Mandat ◽  
H. Koziara ◽  
R. Rola ◽  
T. Tykocki ◽  
W. Bonicki ◽  
...  

2018 ◽  
Vol 33 (6) ◽  
pp. 413-416 ◽  
Author(s):  
C. Michael Honey ◽  
Armaan K. Malhotra ◽  
Maja Tarailo-Graovac ◽  
Clara D. M. van Karnebeek ◽  
Gabriella Horvath ◽  
...  

Dystonic storm or status dystonicus is a life-threatening hyperkinetic movement disorder with biochemical alterations due to the excessive muscle contractions. The medical management can require pediatric intensive care unit admission and a combination of medications while the underlying trigger is managed. Severe cases may require general anesthesia and paralytic agents with intubation and may relapse when these drugs are weaned. Deep brain stimulation of the globus pallidum has been reported to terminate dystonic storm in several pediatric cases. We present a 10-year-old boy with a de novo GNAO1 mutation–induced dystonic storm who required a 2-month pediatric intensive care unit admission and remained refractory to all medical treatments. Deep brain stimulation was performed under general anesthetic without complication. His dyskinetic movements stopped with initiation of stimulation. He was discharged from the pediatric intensive care unit after 4 days. We present prospectively evaluated changes in dystonia symptoms and quality of life for a patient with GNAO1 mutation treated with deep brain stimulation.


2016 ◽  
Vol 94 (4) ◽  
pp. 207-215 ◽  
Author(s):  
Sharona Ben-Haim ◽  
Virginia Flatow ◽  
Tyler Cheung ◽  
Catherine Cho ◽  
Michele Tagliati ◽  
...  

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