Multimodal assessment of early tumor response to chemotherapy: comparison between diffusion-weighted MRI, 1H-MR spectroscopy of choline and USPIO particles targeted at cell death

2011 ◽  
Vol 25 (4) ◽  
pp. 514-522 ◽  
Author(s):  
K. A. Radermacher ◽  
J. Magat ◽  
C. Bouzin ◽  
S. Laurent ◽  
T. Dresselaers ◽  
...  
Keyword(s):  
Cell Death ◽  
Mr Spectroscopy ◽  
Tumor Response ◽  
Diffusion Weighted Mri ◽  
Multimodal Assessment ◽  
1H Mr Spectroscopy ◽  
Diffusion Weighted ◽  
Response To Chemotherapy ◽  
Early Tumor Response ◽  
Early Tumor

scholarly journals Diffusion-weighted MRI of the liver for early tumor response assessment: Promising technique but evidence is still lacking

2010 ◽  
Vol 49 (2) ◽  
pp. 252-255 ◽  
Author(s):  
Sara M. Willems ◽  
Paula S. Koekkoek ◽  
Thomas C. Kwee ◽  
Maurice A.A.J. van den Bosch
Keyword(s):  
Tumor Response ◽  
Response Assessment ◽  
Diffusion Weighted Mri ◽  
Promising Technique ◽  
Diffusion Weighted ◽  
Early Tumor Response ◽  
Early Tumor

Combined 1H MR spectroscopy and diffusion-weighted MRI improves the prediction of stroke outcome

Neurology ◽  
2000 ◽  
Vol 55 (4) ◽  
pp. 498-506 ◽  
Author(s):  
M. W. Parsons ◽  
T. Li ◽  
P. A. Barber ◽  
Q. Yang ◽  
D. G. Darby ◽  
...  
Keyword(s):  
Mr Spectroscopy ◽  
Stroke Outcome ◽  
Diffusion Weighted Mri ◽  
1H Mr Spectroscopy ◽  
Diffusion Weighted ◽  
And Diffusion

Combined Use of Diffusion-Weighted MRI and 1H MR Spectroscopy to Increase Accuracy in Prostate Cancer Detection

2007 ◽  
Vol 188 (1) ◽  
pp. 91-98 ◽  
Author(s):  
Stefan A. Reinsberg ◽  
Geoffrey S. Payne ◽  
Sophie F. Riches ◽  
Sue Ashley ◽  
Jonathan M. Brewster ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Detection ◽  
Mr Spectroscopy ◽  
Diffusion Weighted Mri ◽  
Prostate Cancer Detection ◽  
1H Mr Spectroscopy ◽  
Diffusion Weighted ◽  
Combined Use

scholarly journals MR elastography derived shear stiffness-a new imaging biomarker for the assessment of early tumor response to chemotherapy

2013 ◽  
Vol 71 (5) ◽  
pp. 1834-1840 ◽  
Author(s):  
Kay M. Pepin ◽  
Jun Chen ◽  
Kevin J. Glaser ◽  
Yogesh K. Mariappan ◽  
Brian Reuland ◽  
...  
Keyword(s):  
Tumor Response ◽  
Shear Stiffness ◽  
Imaging Biomarker ◽  
Mr Elastography ◽  
Response To Chemotherapy ◽  
Early Tumor Response ◽  
Early Tumor

scholarly journals The Predictive Value of Tumor Volume, Inflammatory Biomarkers, and Their Dynamic Changes on Early Tumor Response for Elderly Patients With Esophageal Squamous Cell Carcinoma Underwent Radiotherapy

2021 ◽  
Author(s):  
Shuai Liang ◽  
Chengming Li ◽  
Lu Wang ◽  
Dongshui Xu ◽  
Zhao Liu ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Elderly Patients ◽  
Cell Carcinoma ◽  
Tumor Volume ◽  
Tumor Response ◽  
Inflammatory Biomarkers ◽  
Dynamic Changes ◽  
Early Tumor Response ◽  
Early Tumor

Abstract Background: To investigate the tumor volume, pre-treatment inflammatory biomarkers (pre-IBs), and their dynamic changes on early tumor response (ETR) in elderly patients (≥70 years) with esophageal squamous cell carcinoma (ESCC) underwent radiotherapy.Methods: The ETR was assessed according to RECIST 1.1 at 1 month after radiotherapy. The tumor volume ((gross tumor volume (GTV) at the initial treatment planning (GTVi), and GTV at shrinking irradiation field planning (GTVs)), IBs (neutrophil/lymphocyte (NLR), platelet/lymphocyte (PLR), and lymphocyte/monocyte (LMR)) which also included during treatment IBs (dur-IBs), and clinical variables were collected and analyzed from 197 patients received radiotherapy at our institution between 2015 and 2020. The tumor volume change rate (TVCR) and dynamic changes of IBs (delta-IBs) were defined as follows: TVCR=(1-GTVs/GTVi)×100%, delta-IBs=1-dur-IBs/pre-IBs. A nomogram based on logistic regression analysis were then established for predicting ETR.Results: GTVi and pre-LMR significantly decreased, pre-NLR, and pre-PLR significantly increased during radiotherapy or chemoradiotherapy (all P<0.001). Multivariate analysis indicated that TVCR [OR, 0.197; 95%CI, 0.093-0.414; P<0.001], pre-NLR [OR, 2.568; 95%CI, 1.031-6.394; P=0.043], and delta-NLR [OR, 2.831; 95%CI, 1.126-7.119; P=0.027] were statistically significant with ETR. And c-index of the nomogram established by combining all independent predictors for ETR was 0.769 [95%CI, 0.161–0.302].Conclusion: TVCR, Pre-NLR, and delta-NLR were significant with ETR in elderly patients with ESCC who underwent radiotherapy. And the developed nomogram with superior prediction ability for ETR could assist in patients counseling and guide to make individual treatments and follow-up strategies.

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