scholarly journals Impact of Combined Hormonal Contraceptive Use on Weight Loss: A Secondary Analysis of a Behavioral Weight‐Loss Trial

Obesity ◽  
2020 ◽  
Vol 28 (6) ◽  
pp. 1040-1049
Author(s):  
Ann E. Caldwell ◽  
Adnin Zaman ◽  
Danielle M. Ostendorf ◽  
Zhaoxing Pan ◽  
Bryan B. Swanson ◽  
...  
Author(s):  
Maria I. Rodriguez ◽  
Menolly Kaufman ◽  
Brynna Manibusan ◽  
Lorinda Anderson ◽  
K. John McConnell

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Rosângela C. Rodrigues ◽  
Flávia Schechtman Belham ◽  
Ana Garcia ◽  
Corina Satler ◽  
Carlos Tomaz ◽  
...  

This study aimed at evaluating the availability of the primate Sapajus libidinosus as an animal model for research assessing the physiological effects of the continuous use of combined hormonal contraceptives. In order to do this, six reproductively active female S. libidinosus from the Primate Research Center of the University of Brasília were selected to take part in this experiment. Every 21 days or so, each female received a single dose of combined hormonal contraceptive (algestone acetophenide and 17-enanthate estradiol) in a total of five doses throughout the experiment. The physiological parameters were accessed by means of 13 blood samples from each female, whereas three were gathered during the baseline and 10 samples were collected during the treatment phase. The results showed that the contraceptive use provoked changes in hematological coagulation factors such as an increase in the amount of platelets (p=0.039) and a reduction in both prothrombin (p<0.001) and thromboplastin coagulation time (p<0.001). These results are similar to what has been observed in human patients; thus, it is concluded that S. libidinosus can be successfully used in studies about the physiological impact of hormonal contraceptives.


2019 ◽  
Vol 26 (4) ◽  
pp. 443-448 ◽  
Author(s):  
Jennalee S. Wooldridge ◽  
Matthew S. Herbert ◽  
Jeffrey Hernandez ◽  
Cara Dochat ◽  
Kathryn M. Godfrey ◽  
...  

2021 ◽  
Author(s):  
Melissa Lee Stansbury ◽  
Jean R Harvey ◽  
Rebecca A Krukowski ◽  
Christine A Pellegrini ◽  
Xuewen Wang ◽  
...  

BACKGROUND Standard behavioral weight loss interventions often set uniform physical activity (PA) goals and promote PA self-monitoring; however, adherence remains a challenge and recommendations may not accommodate all individuals. Identifying patterns of PA goal attainment and self-monitoring behavior will offer a deeper understanding of how individuals adhere to different types of commonly prescribed PA recommendations (ie., minutes of moderate-to-vigorous physical activity [MVPA] and daily steps) and guide future recommendations for improved intervention effectiveness. OBJECTIVE This study examined weekly patterns of adherence to steps-based and minutes-based PA goals and self-monitoring behavior during a 6-month online behavioral weight loss intervention. METHODS Participants were prescribed weekly PA goals for steps (7,000 to 10,000 steps/day) and minutes of MVPA (50 to 200 minutes/week) as part of a lifestyle program. Goals gradually increased during the initial 2 months, followed by 4 months of fixed goals. PA was self-reported daily on the study website. For each week, participants were categorized as “adherent” if they self-monitored their PA and met the program PA goal, “suboptimally adherent” if they self-monitored but did not meet the program goal, or “nonadherent” if they did not self-monitor. The probability of transitioning into a less adherent status was examined using multinomial logistic regression. RESULTS Individuals (N=212) were predominantly middle-aged females with obesity, and 31.6% self-identified as a racial/ethnic minority. Initially, 34.4% were categorized as “adherent” to steps-based goals (51.9% “suboptimally adherent” and 13.7% “nonadherent”), and there was a high probability of either remaining “suboptimally adherent” from week-to-week or transitioning to a “nonadherent” status. On the other hand, 70.3% of individuals started out “adherent” to minutes-based goals (16.0% “suboptimally adherent” and 13.7% “nonadherent”), with “suboptimally adherent” seen as the most variable status. During the graded goal phase, individuals were more likely to transition to a less adherent status for minutes-based goals (OR 1.39, 95% CI 1.31-1.48) compared to steps-based goals (OR 1.24, 95% CI 1.17-1.30); however, no differences were seen during the fixed goal phase (minutes-based goals: OR 1.06, 95% CI 1.05, 1.08 versus steps-based goals: OR 1.07, 95% CI 1.05, 1.08). CONCLUSIONS States of vulnerability to poor PA adherence can emerge rapidly and early in obesity treatment. There is a window of opportunity within the initial two months to bring more people towards “adherent” behavior, especially those who fail to meet the prescribed goals but engage in self-monitoring. While this study describes the probability of adhering to steps-based and minutes-based targets, it will be prudent to determine how individual characteristics and contextual states relate to these behavioral patterns, which can inform how best to adapt interventions. CLINICALTRIAL This study was a secondary analysis of a pre-registered randomized trial (Trial Registration: ClinicalTrials.gov NCT02688621).


2018 ◽  
Vol 18 (1) ◽  
pp. e15-e24 ◽  
Author(s):  
Giovanni Grandi ◽  
Angela Toss ◽  
Angelo Cagnacci ◽  
Luigi Marcheselli ◽  
Silvia Pavesi ◽  
...  

2015 ◽  
Vol 172 (4) ◽  
pp. 636-638 ◽  
Author(s):  
Elizabeth F. W. van Vlijmen ◽  
Anja B. U. Mäkelburg ◽  
H. Marieke Knol ◽  
Vladimir I. G. V. Tichelaar ◽  
Hanneke C. Kluin-Nelemans ◽  
...  

Contraception ◽  
2016 ◽  
Vol 94 (3) ◽  
pp. 262-274 ◽  
Author(s):  
Naomi K. Tepper ◽  
Sharon J. Phillips ◽  
Nathalie Kapp ◽  
Mary E. Gaffield ◽  
Kathryn M. Curtis

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