Tween 20-modified poly(vinyl chloride) exhibits enhanced blood-compatibility

2005 ◽  
Vol 54 (9) ◽  
pp. 1304-1309 ◽  
Author(s):  
Biji Balakrishnan ◽  
Nirmala R James ◽  
A Jayakrishnan
1989 ◽  
Vol 261 (3) ◽  
pp. 715-720 ◽  
Author(s):  
P B McGinlay ◽  
W G Bardsley

Experiments were performed to measure the effect of pH, ionic strength, temperature, organic solvents, pretreatment with gelatin and Tween 20 on the rate and extent of binding of human IgG to the walls of poly(vinyl chloride) e.l.i.s.a. vessels. It is demonstrated that, over a wide range of experimental conditions, the binding is controlled by rate-limiting diffusion to the walls, followed by a rapid and irreversible adsorption. A mathematical model is derived and shown to give a good fit to the experimental data points.


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