Pharmacological characterization of cebranopadol a novel analgesic acting as mixed nociceptin/orphanin FQ and opioid receptor agonist

Anna Rizzi; Maria Camilla Cerlesi; Chiara Ruzza; Davide Malfacini; Federica Ferrari; Sara Bianco; Tommaso Costa; Remo Guerrini; Claudio Trapella; Girolamo Calo'

doi:10.1002/prp2.247

Pharmacological characterization of cebranopadol a novel analgesic acting as mixed nociceptin/orphanin FQ and opioid receptor agonist

Pharmacology Research & Perspectives ◽

10.1002/prp2.247 ◽

2016 ◽

Vol 4 (4) ◽

Cited By ~ 35

Author(s):

Anna Rizzi ◽

Maria Camilla Cerlesi ◽

Chiara Ruzza ◽

Davide Malfacini ◽

Federica Ferrari ◽

...

Keyword(s):

Opioid Receptor ◽

Receptor Agonist ◽

Orphanin Fq ◽

Pharmacological Characterization ◽

Opioid Receptor Agonist

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Cebranopadol: A Novel Potent Analgesic Nociceptin/Orphanin FQ Peptide and Opioid Receptor Agonist

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.114.213694 ◽

2014 ◽

Vol 349 (3) ◽

pp. 535-548 ◽

Cited By ~ 91

Author(s):

Klaus Linz ◽

Thomas Christoph ◽

Thomas M. Tzschentke ◽

Thomas Koch ◽

Klaus Schiene ◽

...

Keyword(s):

Opioid Receptor ◽

Receptor Agonist ◽

Orphanin Fq ◽

Opioid Receptor Agonist

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Design, Synthesis, and Characterization of the Macrocyclic Tetrapeptide cyclo[Pro-Sar-Phe-d-Phe]: A Mixed Opioid Receptor Agonist–Antagonist Following Oral Administration

ACS Chemical Neuroscience ◽

10.1021/acschemneuro.0c00086 ◽

2020 ◽

Vol 11 (9) ◽

pp. 1324-1336 ◽

Cited By ~ 1

Author(s):

Michael J. Ferracane ◽

Ariana C. Brice-Tutt ◽

Jeremy S. Coleman ◽

Grant G. Simpson ◽

Lisa L. Wilson ◽

...

Keyword(s):

Oral Administration ◽

Opioid Receptor ◽

Receptor Agonist ◽

Synthesis And Characterization ◽

Design Synthesis ◽

Opioid Receptor Agonist

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Synthesis and characterization of biotinylated and desbiotinylated analogues of DALDA, μ-opioid receptor agonist.

The Japanese Journal of Pharmacology ◽

10.1016/s0021-5198(19)51467-6 ◽

1993 ◽

Vol 61 ◽

pp. 142

Author(s):

Shizuo Yamada ◽

Ulrich Bickel ◽

William M. Pardridge

Keyword(s):

Opioid Receptor ◽

Receptor Agonist ◽

Synthesis And Characterization ◽

Opioid Receptor Agonist ◽

Μ Opioid Receptor

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Characterization of the complex morphinan derivative BU72 as a high efficacy, long-lasting mu-opioid receptor agonist

European Journal of Pharmacology ◽

10.1016/j.ejphar.2004.07.097 ◽

2004 ◽

Vol 499 (1-2) ◽

pp. 107-116 ◽

Cited By ~ 30

Author(s):

Claire L. Neilan ◽

Stephen M. Husbands ◽

Simon Breeden ◽

M.C. (Holden) Ko ◽

Mario D. Aceto ◽

...

Keyword(s):

Opioid Receptor ◽

Receptor Agonist ◽

Mu Opioid Receptor ◽

High Efficacy ◽

Mu Opioid ◽

Opioid Receptor Agonist

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Characterization of the discriminative stimulus effects of the delta‐opioid receptor agonist, SNC80, in rats

The FASEB Journal ◽

10.1096/fasebj.2018.32.1_supplement.822.4 ◽

2018 ◽

Vol 32 (S1) ◽

Author(s):

Ashleigh L. Matthews ◽

Kenner C. Rice ◽

Emily M. Jutkiewicz

Keyword(s):

Opioid Receptor ◽

Discriminative Stimulus ◽

Receptor Agonist ◽

Delta Opioid Receptor ◽

Discriminative Stimulus Effects ◽

Opioid Receptor Agonist ◽

Stimulus Effects

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Synthesis and Characterization of a Dual Kappa-Delta Opioid Receptor Agonist Analgesic Blocking Cocaine Reward Behavior

ACS Chemical Neuroscience ◽

10.1021/acschemneuro.5b00153 ◽

2015 ◽

Vol 6 (11) ◽

pp. 1813-1824 ◽

Cited By ~ 20

Author(s):

András Váradi ◽

Gina F. Marrone ◽

Shainnel O. Eans ◽

Michelle L. Ganno ◽

Joan J. Subrath ◽

...

Keyword(s):

Opioid Receptor ◽

Receptor Agonist ◽

Synthesis And Characterization ◽

Delta Opioid Receptor ◽

Opioid Receptor Agonist ◽

Cocaine Reward

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Characterization of Neuroprotective Effects of Biphalin, an Opioid Receptor Agonist, in a Model of Focal Brain Ischemia

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.111.184127 ◽

2011 ◽

Vol 339 (2) ◽

pp. 499-508 ◽

Cited By ~ 22

Author(s):

Li Yang ◽

Kaushik Shah ◽

Hezhen Wang ◽

Vardan T. Karamyan ◽

Thomas J. Abbruscato

Keyword(s):

Opioid Receptor ◽

Brain Ischemia ◽

Receptor Agonist ◽

Neuroprotective Effects ◽

Opioid Receptor Agonist ◽

Focal Brain Ischemia

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Characterization of methadone as a β-arrestin-biased μ-opioid receptor agonist

Molecular Pain ◽

10.1177/1744806916654146 ◽

2016 ◽

Vol 12 ◽

pp. 174480691665414 ◽

Cited By ~ 12

Author(s):

Seira Doi ◽

Tomohisa Mori ◽

Naoki Uzawa ◽

Takamichi Arima ◽

Tomoyuki Takahashi ◽

...

Keyword(s):

Opioid Receptor ◽

Receptor Agonist ◽

Opioid Receptor Agonist ◽

Μ Opioid Receptor

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Behavioral Characterization of κ Opioid Receptor Agonist Spiradoline and Cannabinoid Receptor Agonist CP55940 Mixtures in Rats

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.116.235630 ◽

2016 ◽

Vol 360 (2) ◽

pp. 280-287 ◽

Cited By ~ 5

Author(s):

Vanessa Minervini ◽

Sujata Dahal ◽

Charles P. France

Keyword(s):

Opioid Receptor ◽

Receptor Agonist ◽

Cannabinoid Receptor ◽

Opioid Receptor Agonist ◽

Behavioral Characterization

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Antihyperalgesic, Antiallodynic, and Antinociceptive Effects of Cebranopadol, a Novel Potent Nociceptin/Orphanin FQ and Opioid Receptor Agonist, after Peripheral and Central Administration in Rodent Models of Neuropathic Pain

Pain Practice ◽

10.1111/papr.12558 ◽

2017 ◽

Vol 17 (8) ◽

pp. 1032-1041 ◽

Cited By ~ 16

Author(s):

Thomas M. Tzschentke ◽

Klaus Linz ◽

Stefanie Frosch ◽

Thomas Christoph

Keyword(s):

Neuropathic Pain ◽

Opioid Receptor ◽

Receptor Agonist ◽

Rodent Models ◽

Central Administration ◽

Orphanin Fq ◽

Opioid Receptor Agonist ◽

Antinociceptive Effects

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