Effect of (−)-cathinone, an active principle ofCatha edulis forssk. (Khat) on plasma amino acid levels and other biochemical parameters in male wistar rats

ABSTRACT Objective Iron deficiency and vitamin A deficiency are two of the main micronutrient deficiencies. Both micronutrients are essential for human life and children's development. This study aimed to investigate the effects of vitamin A deficiency on ferritin and transferrin receptors' expression and its relationship with iron deficiency. Methods Five diets with different vitamin A-to-iron ratios were given to thirty five 21-day-old male Wistar rats (separated in groups of seven animals each). The animals received the diet for six weeks before being euthanized. Serum iron and retinol levels were measured as biochemical parameters. Their duodenums, spleens, and livers were analyzed for the expression of ferritin and transferrin receptors by Western Blotting. Results Regarding biochemical parameters, the results show that when both vitamin A and iron are insufficient, the serum iron content (74.74µg/dL) is significantly lower than the control group (255.86µg/dL). The results also show that vitamin A deficiency does not influence the expression of the transferrin receptor, but only of the ferritin one. Conclusion Vitamin A deficiency regulates the expression of ferritin in young male Wistar rats.

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The effects of N-acetyl-L-cysteine on subchronic methionine load in male wistar rats: Focus on standard biochemical parameters and markers of homocysteine metabolism in blood

Atherosclerosis ◽

10.1016/j.atherosclerosis.2018.06.642 ◽

2018 ◽

Vol 275 ◽

pp. e206-e207

Author(s):

A. Djuric ◽

M. Colovic ◽

D. Krstic ◽

R. Obrenovic ◽

Z. Micovic ◽

...

Keyword(s):

Biochemical Parameters ◽

Wistar Rats ◽

Methionine Load ◽

Male Wistar Rats

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The Effects of Test Doses of Leucine, Isoleucine or Valine on Plasma Amino Acid Levels

American Journal of Clinical Nutrition ◽

10.1093/ajcn/17.5.317 ◽

1965 ◽

Vol 17 (5) ◽

pp. 317-321 ◽

Cited By ~ 35

Author(s):

MARIAN E. SWENDSEID ◽

JUANITA VILLALOBOS ◽

WILLIAM S. FIGUEROA ◽

ERNST J. DRENICK

Keyword(s):

Amino Acid ◽

Plasma Amino Acid ◽

Amino Acid Levels

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P079 CHANGES IN PLASMA AMINO ACID LEVELS: A MINIMALLY INVASIVE INNOVATIVE WAY TO DIAGNOSE INTESTINAL REJECTION IN PIGS

Clinical Nutrition Supplements ◽

10.1016/s1744-1161(09)70129-2 ◽

2009 ◽

Vol 4 (2) ◽

pp. 58

Author(s):

T. Yandza ◽

N. Neveux ◽

M. Saint-Paul ◽

F. Berthier ◽

J. Gugenheim ◽

...

Keyword(s):

Amino Acid ◽

Minimally Invasive ◽

Plasma Amino Acid ◽

Amino Acid Levels

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BLOOD AMINO ACID STUDIES: IV. SOME FACTORS AFFECTING PLASMA AMINO ACID LEVELS IN HUMAN SUBJECTS

Canadian Journal of Biochemistry and Physiology ◽

10.1139/y63-024 ◽

1963 ◽

Vol 41 (1) ◽

pp. 191-199 ◽

Cited By ~ 3

Author(s):

J. M. McLaughlan ◽

F. J. Noel ◽

A. B. Morrison ◽

J. A. Campbell

Keyword(s):

Amino Acid ◽

Human Subjects ◽

Plasma Amino Acid ◽

Small Samples ◽

Breakfast Cereal ◽

Specific Amino Acid ◽

Factors Affecting ◽

Practical Procedure ◽

Plasma Amino Acid Response ◽

Amino Acid Levels

Free lysine, methionine, threonine, and tryptophan were determined in small samples of blood obtained by finger punch from human subjects. The levels of the four amino acids rose rapidly after the subjects consumed protein as baked halibut; the extent and duration of the increases were roughly proportional to the amount of protein eaten and to the amino acid composition of the protein. The increases of free methionine and threonine in plasma were somewhat less when butter was taken with fish but starch (as potato) or sucrose did not affect the values. Other foods tested at the 19.0-g level of protein included egg, a commercial breakfast cereal, and the same cereal plus milk. In general the increase or decrease of each amino acid tested was related to the amount of that amino acid in the test food. The plasma amino acid (PAA) ratio of Longenecker and Hause was calculated for each food and was useful in evaluating the increase or decrease of each specific amino acid. The present work appears to offer a practical procedure for studying the plasma amino acid response of groups of human subjects to variations in dietary protein.

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