Apoptosis and autophagy modulating dietary phytochemicals in cancer therapeutics: Current evidences and future perspectives

Telomerase, an enzyme responsible for the synthesis of telomeres, is activated in many cancer cells and is involved in the maintenance of telomeres. The activity of telomerase allows cancer cells to replicate and proliferate in an uncontrolled manner, to infiltrate tissue, and to metastasize to distant organs. Studies to date have examined the mechanisms involved in the survival of cancer cells as targets for cancer therapeutics. These efforts led to the development of telomerase inhibitors as anticancer drugs, drugs targeting telomere DNA, viral vectors carrying a promoter for human telomerase reverse transcriptase (hTERT) genome, and immunotherapy targeting hTERT. Among these novel therapeutics, this review focuses on immunotherapy targeting hTERT and discusses the current evidence and future perspectives.

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Peroxidase Mimetic Nanozymes in Cancer Phototherapy: Progress and Perspectives

Biomolecules ◽

10.3390/biom11071015 ◽

2021 ◽

Vol 11 (7) ◽

pp. 1015

Author(s):

Suresh Thangudu ◽

Chia-Hao Su

Keyword(s):

Oxygen Carrier ◽

Tumor Hypoxia ◽

Cancer Therapeutics ◽

Detailed Examination ◽

Clinical Applications ◽

Oxygen Species ◽

Future Perspectives ◽

Practical Applications ◽

Radio Therapy ◽

Hypoxic Tumor

Nanomaterial-mediated cancer therapeutics is a fast developing field and has been utilized in potential clinical applications. However, most effective therapies, such as photodynamic therapy (PDT) and radio therapy (RT), are strongly oxygen-dependent, which hinders their practical applications. Later on, several strategies were developed to overcome tumor hypoxia, such as oxygen carrier nanomaterials and oxygen generated nanomaterials. Among these, oxygen species generation on nanozymes, especially catalase (CAT) mimetic nanozymes, convert endogenous hydrogen peroxide (H2O2) to oxygen (O2) and peroxidase (POD) mimetic nanozymes converts endogenous H2O2 to water (H2O) and reactive oxygen species (ROS) in a hypoxic tumor microenvironment is a fascinating approach. The present review provides a detailed examination of past, present and future perspectives of POD mimetic nanozymes for effective oxygen-dependent cancer phototherapeutics.

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Postscript. Future Perspectives

Comprehensive Series in Photochemical & Photobiological Sciences - Microalgal Hydrogen Production ◽

10.1039/9781849737128-00483 ◽

2018 ◽

pp. 483-487

Author(s):

Giuseppe Torzillo ◽

Michael Seibert

Keyword(s):

Future Perspectives

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Schottky diodes based on 2D materials for environmental gas monitoring: a review on emerging trends, recent developments and future perspectives

Journal of Materials Chemistry C ◽

10.1039/d0tc04840b ◽

2021 ◽

Author(s):

Minu Mathew ◽

Chandra Sekhar Rout

Keyword(s):

Gas Sensing ◽

2D Materials ◽

Schottky Diodes ◽

High Sensitivity ◽

Future Perspectives ◽

Working Temperature ◽

Emerging Trends ◽

Gas Sensing Properties ◽

Recent Developments ◽

Sensitivity And Selectivity

This review details the fundamentals, working principles and recent developments of Schottky junctions based on 2D materials to emphasize their improved gas sensing properties including low working temperature, high sensitivity, and selectivity.

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