Effects of Nigella sativa oil supplementation on selected metabolic parameters and anthropometric indices in patients with coronary artery disease: A randomized, double‐blind, placebo‐controlled clinical trial

2021 ◽  
Author(s):  
Omid Mohammad Tavakoli‐Rouzbehani ◽  
Mohsen Abbasnezhad ◽  
Sorayya Kheirouri ◽  
Mohammad Alizadeh
Keyword(s):  
Coronary Artery Disease ◽  
Clinical Trial ◽  
Coronary Artery ◽  
Nigella Sativa ◽  
Controlled Clinical Trial ◽  
Anthropometric Indices ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Nigella Sativa Oil ◽  
Artery Disease

Effect of Gundelia tournefortii L. extract on lipid profile and TAC in patients with coronary artery disease: A double-blind randomized placebo controlled clinical trial

2016 ◽  
Vol 6 (2) ◽  
pp. 59-66 ◽  
Author(s):  
Fatemeh Hajizadeh-Sharafabad ◽  
Mohammad Alizadeh ◽  
Mir Hosein Seyyed Mohammadzadeh ◽  
Saeedeh Alizadeh-Salteh ◽  
Sorayya Kheirouri
Keyword(s):  
Coronary Artery Disease ◽  
Clinical Trial ◽  
Coronary Artery ◽  
Lipid Profile ◽  
Controlled Clinical Trial ◽  
Double Blind ◽  
Artery Disease

The effect of crocetin supplementation on markers of atherogenic risk in patients with coronary artery disease: a pilot, randomized, double-blind, placebo-controlled clinical trial

2019 ◽  
Vol 10 (11) ◽  
pp. 7461-7475
Author(s):  
Saeed Abedimanesh ◽  
S. Zahra Bathaie ◽  
Alireza Ostadrahimi ◽  
Mohammad Asghari Jafarabadi ◽  
Mohammadreza Taban Sadeghi
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Cell Adhesion Molecules ◽  
Controlled Clinical Trial ◽  
Related Gene ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Positive Effects ◽  
Endothelial Cell Adhesion Molecules ◽  
Artery Disease

Two-month crocetin supplementation (10 mg day−1) in patients with Coronary Artery Disease (CAD) has positive effects on some atherogenesis-related gene expression, endothelial cell adhesion molecules, HDL, h-FABP, and homocysteine.

scholarly journals The Effects of Nigella Sativa Extract Oil Supplementation on Plasma Level of ICAM-1, VCAM-1, Metabolic and Oxidative Parameters and Nutritional Status in Patients With Coronary Artery Disease: Study Protocol for A Double-Blind, Randomized Controlled Trial

2020 ◽  
Author(s):  
Omid Mohammad Tavakoli-Rouzbehani ◽  
Mohsen Abbasnezhad ◽  
Vahid Maleki ◽  
Alireza Rahmani ◽  
Mohammad Alizadeh
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Clinical Trial ◽  
Coronary Artery ◽  
Vascular Function ◽  
Nigella Sativa ◽  
Controlled Trial ◽  
Clinical Trial Registry ◽  
Double Blind ◽  
Artery Disease

Abstract Background: endothelial and metabolic dysfunction are the main risk factors for atherosclerosis, which eventually leads to cardiovascular diseases, such as coronary artery disease (CAD). However, it has been shown that increased inflammation and oxidative stress play an essential role in this process. Nigella sativa may affect declining atherosclerosis and CAD by reducing inflammation and improving vascular function.Methods: Two sections that are presented in this article include; first, a review of recent findings related to cardiovascular disease, CAD, and their association with N. sativa supplementation. Secondly, we will illustrate a randomized, double-blind clinical trial in 46 Iranian adults with CAD. The subjects (age: 35-65, proof of 50% stenosis in at least one of their major coronary arteries in angiography) will be selected by a simple random sampling method and will be assigned to two months supplementation of N. sativa extract oil or placebo group. The primary outcome is the inflammatory and oxidative variables. The secondary outcomes measures include lipid profile, quality of life, depression, and anthropometric indices. The data will be equated within and between groups using appropriate statistical methods. Discussion: The result of this trial will offer evidence about the efficacy of N. sativa supplementation by improving risk factors related to atherosclerosis and coronary artery disease. Trial registration: Iranian clinical trial registry: IRCT20190506043494N1, Date of registration: November 8, 2019.

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