Ovarian reserve after three‐step laparoscopic surgery for endometriomas utilizing dienogest: A pilot study

The aim: To assess the effect of COMT G1947A genetic polymorphism (val158met) on the efficacy of spinal analgesia on day 1 after laparoscopic surgery for colorectal cancer.Material and methods. In a pilot study involving 100 patients with colorectal cancer, operated through laparoscopic access, using spinal analgesia (10.0–12.5 mg of bupivacaine + 200 mcg of morphine), the frequency of COMT gene G1947A (val158met) polymorphism, the intensity of pain on day 1 after surgery, the frequency and severity of nausea, vomiting, skin itching, the need for additional analgesia have been assessed.Results. The frequency distribution of alleles val/val (25%), val/met (45%) and met/met (30%) was consisted with Hardy-Weinberg equilibrium (χ2=0.96; P>0.05) and was not significantly different from the healthy donor group. In the groups of patients with various COMT alleles of val158met polymorphism, the studied parameters also did not differ significantly.Conclusion. Study did not find significant link between spinal analgesia efficacy on day 1 after laparoscopic surgery for colorectal cancer and COMT rs4680 G1947A (val158met) polymorphism. Further research to enhance the power of the study is warranted to reach the final conclusions.

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Evaluation of the safety and efficacy of suction-tip forceps, a new tool for laparoscopic surgery, in patients with gastric cancer: Preliminary results from a prospective trial

10.21203/rs.2.17093/v1 ◽

2019 ◽

Author(s):

Nobuyuki Sakurazawa ◽

Jun-ichiro Harada ◽

Fumihiko Ando ◽

Hiroki Arai ◽

Komei Kuge ◽

...

Keyword(s):

Gastric Cancer ◽

Laparoscopic Surgery ◽

Pilot Study ◽

Tissue Damage ◽

Access Time ◽

Dual Function ◽

Safety And Efficacy ◽

Prospective Pilot Study ◽

Suction Tube ◽

New Instrument

Abstract Background Laparoscopic surgery is widely accepted as minimally invasive surgery; however, obstacles to its functional optimization remain. One such challenge is that each surgical port can accommodate only one instrument at a time. Complex manipulations are therefore necessary to exchange one laparoscopic tool with another during surgery (e.g., removal of forceps and placement of a suction tube), which increases operation times and risk to patients. We developed a new laparoscopic instrument that functions as both forceps and a suction tube, which renders intraoperative tool exchange unnecessary. This prospective pilot study was undertaken to evaluate the safety and efficacy of this novel dual-function device in laparoscopic surgery for gastric cancer. Methods This single-center prospective pilot study was undertaken with 15 patients who required laparoscopic distal gastrectomy for gastric cancer. To assess patient safety, intraoperative video was used to document any tissue damage associated with the new instrument. To evaluate instrument efficacy, we measured the time interval between the start of bleeding and the start of aspiration (“suction access time”) and compared this time with that of a conventional surgical setup. Results All procedures were successful, and no excess tissue damage occurred during surgery with the suction-tip forceps. Bleeding occurred 158 times. Suction access time was significantly shorter in cases of bleeding when the suction-tip forceps were used (2.01 seconds) than when an ordinary suction tube was used for aspiration (12.5 seconds; P < 0.01). Conclusion These findings suggest that our new suction-tip forceps are a useful, safe, and efficacious operative tool. This surgical innovation may considerably simplify gastric laparoscopic surgery. This pilot study was registered with Japan Clinical Trial Registration on June 22, 2017 (registration number: UMIN000027879).

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A model of pilot study to assess the risk of exposure to surgical smokes for operating room personnel

Proceedings of the 8th International Workshop on Innovative Simulation for Healthcare (IWISH 2019) ◽

10.46354/i3m.2019.iwish.008 ◽

2019 ◽

Author(s):

Marco Frascio ◽

Matteo Mascherini ◽

Paola Batistotti ◽

Katia Cortese ◽

Rosario Fornaro

Keyword(s):

Laparoscopic Surgery ◽

Pilot Study ◽

Operating Room ◽

Health Risks ◽

Toxic Elements ◽

Operating Room Personnel ◽

Toxic Concentration ◽

Individual Protection ◽

Protection Devices ◽

Risk Of Exposure

"During the last decades the exposure to surgical smokes has been a long-standing concern both in open and laparoscopic surgery. The aim of this project is to assess the health risks for medical operating room (OR) personnel associated with surgical plumes derived from laparoscopic procedures. The purpose of this model is to check the correlation between the concentration of toxic elements derived from electrosurgical procedures in the operating setting air and the concentration of the same substances in urine and plasma of patients and operating staff. Moreover, it will be considered also the correlation between toxic concentration and time of exposure. The results of the study could be relevant to indicate if individual protection devices are efficacious to make the surgical procedure safe for patients and staff or if any adequacy has to be considered. Some unexpected difficulties delayed the expected results."

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